IGF-IRα (2C8) Antibody sc-463 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemIGF-IRα (2C8) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-463
NCBI Gene AliasesIGFR, D930020L01, IGFIR, A330103N21Rik, CD221, IGF-1R, JTK13, hyft
Antibody TypePrimary Antibodies
Clone2C8
Quantity200 µg/ml
ApplicationsWB, IP, IF, IHC(P)
Reactivitymouse, rat, human
FormatPurified
Conjugate/TagUnconjugated
ClonalityMonoclonal
Hostmouse
NCBI Full Gene Nameinsulin like growth factor 1 receptor, insulin-like growth factor I receptor
TargetIGF-IRalpha
IsotypeIgG1

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Macrophage-derived IGF-1 protects the neonatal intestine against necrotizing enterocolitis by promoting microvascular developmentCommunications biologyApril 6, 2022Yan X, Managlia E, Zhao YY, Tan XD, De Plaen IG.anti-IGF-1R Ab (sc-462) and their isotype controls (for FACS), anti-VEGF-A Ab (sc-7269), and anti-IGF-1Rα Ab (sc-463) for western blotting were obtained from Santa Cruz Biotechnology (Santa Cruz, CA). Anti-IGF-1 Ab for western blotting

(2) Insulin-like growth factor 1 gene transfer for sporadic Alzheimer's disease: New evidence for trophic factor mediated hippocampal neuronal and synaptic recovery-based behavior improvementHippocampusOctober 1, 2021Zappa Villar MF, López Hanotte J, Crespo R, Pardo J, Reggiani PC.

(3) S6K1 blockade overcomes acquired resistance to EGFR-TKIs in non-small cell lung cancerOncogeneDecember 1, 2020Shen H, Wang GC, Li X, Ge X, Wang M, Shi ZM, Bhardwaj V, Wang ZX, Zinner RG, Peiper SC, et al.(#4858), p-AKT (#4060 CST), and S6K1 (#2708) antibodies were from Cell Signaling Technology. IGF-IR (sc463), p-IGF-IR (sc81499), TFEB (sc166736) antibodies were from Santa Cruz Biotech. p-TFEB antibody was obtained

(4) Long non‑coding RNA BANCR mediates esophageal squamous cell carcinoma progression by regulating the IGF1R/Raf/MEK/ERK pathway via miR‑338‑3pInternational journal of molecular medicineOctober 1, 2020Song W, Wang K, Yang X, Dai W, Fan Z.Image Lab™ Software (Bio-Rad Laboratories, Inc.). The primary anti-bodies used were as follows: Anti-IGF1R (sc-463; 1:500, Santa Cruz Biotechnology, Inc.), anti-p-MEK1/2 (#2338, 1:2,000), anti-MEK1/2 (#9122, 1:1,000)

(5) Activation of epidermal growth factor receptor/insulin-like growth factor 1 receptor-β-Catenin-CD44 pathway in periampullary cancerJournal of Radiation and Cancer ResearchJanuary 1, 2020ChinmayKumar Panda, Biswabandhu Bankura, Suvendu Maji, Balarko Chakraborty, Neyaz Alamdilution of 1:80–1:100 were used for overnight incubation. The primary antibodies of EGFR (Sc‑03), IGF1R (Sc‑463), β‑catenin (sc‑7199), and CD44 (sc‑7297) were purchased from Santa Cruz Biotechnology, Inc., USA. The HRP‑conjugated

(6) Oral Administration of Microencapsulated B. Longum BAA-999 and Lycopene Modulates IGF-1/IGF-1R/IGFBP3 Protein Expressions in a Colorectal Murine ModelInternational journal of molecular sciencesAugust 31, 2019Valadez-Bustos N, Escamilla-Silva EM, García-Vázquez FJ, Gallegos-Corona MA, Amaya-Llano SL, Ramos-Gómez M.expressions of IGF-1 (W18, SC-74116 catalog number), IGF-2 (8H1, SC-293176 catalog number), IGF-1R (2C8, SC-463 catalog number), IGF2BP1 (D-9, SC-166344 catalog number), IGFBP2 (G-4, SC-515134 catalog number), and

(7) Sialyl Lewis^x-P-selectin cascade mediates tumor-mesothelial adhesion in ascitic fluid shear flowNature communicationsJune 3, 2019Li SS, Ip CKM, Tang MYH, Tang MKS, Tong Y, Zhang J, Hassan AA, Mak ASC, Yung S, Chan TM, et al.2 mM EDTA, 150 mM NaCl, 1% NP-40, 50 mM Tris pH 7.4, and protease inhibitor cocktail. Anti-IGF-1R (sc-463, Santa Cruz Biotechnology) was immobilized on cyanogen bromide (CNBr)-activated sepharose (GE Healthcare)

(8) IGF-1 receptor cleavage in hypertensionHypertension research : official journal of the Japanese Society of HypertensionJune 1, 2018Cirrik S, Schmid-Schönbein GW.alpha monoclonal antibody (1:400; Santa Cruz Biotechnology Inc., Santa Cruz, CA, USA; catalog number sc-463) or rabbit anti-rat IGF-1R beta polyclonal antibody (1:100; Cell Signaling Technology Inc., Beverly,

(9) Selective estrogen receptor modulator ormeloxifene suppresses embryo implantation via inducing miR-140 and targeting insulin-like growth factor 1 receptor in rat uterusThe Journal of steroid biochemistry and molecular biologyApril 1, 2018Sirohi VK, Gupta K, Kumar R, Shukla V, Dwivedi A.

(10) Treatment with 17β-Estradiol Reduced Body Weight and the Risk of Cardiovascular Disease in a High-Fat Diet-Induced Animal Model of ObesityInternational journal of molecular sciencesMarch 14, 2017Ting WJ, Huang CY, Jiang CH, Lin YM, Chung LC, Shen CY, Pai P, Lin KH, Viswanadha VP, Liao SC.Santa Cruz Biotechnology, Dallas, TX, USA), p-IGF1R (sc-101704, Santa Cruz Biotechnology, Dallas, TX, USA), IGF1R (sc-463, Santa Cruz Biotechnology, Dallas, TX, USA), p-JAK (sc-21870, Santa Cruz Biotechnology, Dallas, TX,

(11) Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-IDiabetesJanuary 1, 2017Fernandez AM, Hernandez-Garzón E, Perez-Domper P, Perez-Alvarez A, Mederos S, Matsui T, Santi A, Trueba-Saiz A, García-Guerra L, Pose-Utrilla J, et al.(1:100; catalog #sc-7903; Santa Cruz Biotechnology) and monoclonal mouse anti–IGF-IR (1:100; catalog #sc-463; Santa Cruz Biotechnology), which were processed following the instructions of the supplier using the

(12) The insulin-like growth factor I receptor regulates glucose transport by astrocytesGliaNovember 1, 2016Hernandez-Garzón E, Fernandez AM, Perez-Alvarez A, Genis L, Bascuñana P, Fernandez de la Rosa R, Delgado M, Angel Pozo M, Moreno E, McCormick PJ, et al.

(13) The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinomaTumour biology : the journal of the International Society for Oncodevelopmental Biology and MedicineFebruary 1, 2014Adachi Y, Ohashi H, Imsumran A, Yamamoto H, Matsunaga Y, Taniguchi H, Nosho K, Suzuki H, Sasaki Y, Arimura Y, et al.

(14) Evaluation of a novel hexavalent humanized anti-IGF-1R antibody and its bivalent parental IgG in diverse cancer cell linesPloS oneJanuary 1, 2012Chang CH, Wang Y, Trisal P, Li R, Rossi DL, Nair A, Gupta P, Losman M, Cardillo TM, Rossi EA, et al.

(15) The efficacy of IGF-I receptor monoclonal antibody against human gastrointestinal carcinomas is independent of k-ras mutation statusClinical cancer research : an official journal of the American Association for Cancer ResearchAugust 1, 2011Ii M, Li H, Adachi Y, Yamamoto H, Ohashi H, Taniguchi H, Arimura Y, Carbone DP, Imai K, Shinomura Y.

(16) Insulin-like growth factor-I receptor blockade reduces tumor angiogenesis and enhances the effects of bevacizumab for a human gastric cancer cell line, MKN45CancerJuly 15, 2011Li H, Adachi Y, Yamamoto H, Min Y, Ohashi H, Ii M, Arimura Y, Endo T, Lee CT, Carbone DP, et al.

(17) Mechanisms of antibody-mediated insulin-like growth factor I receptor (IGF-IR) down-regulation in MCF-7 breast cancer cellsBioscience trendsAugust 1, 2009Ohtani M, Numazaki M, Yajima Y, Fujita-Yamaguchi Y.

(18) Insulin-like growth factor-I receptor blockade reduces the invasiveness of gastrointestinal cancers via blocking production of matrilysinCarcinogenesisAugust 1, 2009Adachi Y, Li R, Yamamoto H, Min Y, Piao W, Wang Y, Imsumran A, Li H, Arimura Y, Lee CT, et al.

(19) Insulin receptor substrate-2 mediated insulin-like growth factor-I receptor overexpression in pancreatic adenocarcinoma through protein kinase CdeltaCancer researchFebruary 15, 2009Kwon J, Stephan S, Mukhopadhyay A, Muders MH, Dutta SK, Lau JS, Mukhopadhyay D.

(20) Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomasMolecular cancer therapeuticsJune 1, 2008Piao W, Wang Y, Adachi Y, Yamamoto H, Li R, Imsumran A, Li H, Maehata T, Ii M, Arimura Y, et al.

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IGF-IRα (2C8) Antibody

IGF-IRα (2C8) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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IGF-IRα (2C8) Antibody from Santa Cruz Biotechnology, Inc.

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