Pyk2 (5E2) Mouse mAb 3480S from Cell Signaling Technology

Product Specs
ItemPyk2 (5E2) Mouse mAb
CompanyCell Signaling Technology
Price $336.00 Inquire
Catalog Number3480S
Quantity100 µl
ApplicationsW, W-S, IP
ReactivityH, M
TargetPyk2
HostMouse
NCBI Gene AliasesCADTK, CAKB, FADK2, FAK2, PKB, PTK, PYK2, RAFTK
ClonalityMonoclonal
NCBI Full Gene Nameprotein tyrosine kinase 2 beta
Research AreaMAP Kinase Signaling
IsotypeIgG2a
Clone500
Molecular Weight116

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) FAK inhibition in ovarian cancer releases omega-3 fatty acids to program CXCL13-producing anti-tumor resident peritoneal macrophagesCell ReportsMarch 24, 2026Xiao Lei Chen, Kevin M. Tharp, Marjaana Ojalill, Duygu Ozmadenci, Antonia Boyer, Terrance J. Haanen, Christine Lawson, Hyojae J. Lee, Marvin Xia, Elise Tahon, et al.Antibody (141-9),Thermo Fischer,Cat# 44-625G; RRID: AB_1500096 PYK2 (5E2) Mouse mAb,Cell Signaling,Cat# 3480; RRID: AB_2174093 E-Cadherin (24E10) Rabbit mAb,Cell Signaling,Cat# 3195; RRID: AB_2291471 N-Cadherin (13A9) Mouse mAb

(2) Immunophenotyping identifies key immune biomarkers for coronary artery disease through machine learningPLoS OneAugust 26, 2025Lelin Jiang, Minghao Jiang, Yiying Liu, Wei Zhao, Xinlang Zhou, Ying Liu, Shue Huang, Lina Chen, Wenbing Jiangand Western blotting as previously described [41,42]. Primary antibodies used included anti-PTK2B antibodies (CAT# 3480, 1:1000) and anti-GAPDH antibodies (CAT# 2118, 1:5000), both from Cell Signaling Technology (MA, USA).

(3) A lightweight neural attention-based model for service chatbotsSci RepAugust 13, 2025Sinarwati Mohamad Suhaili, Mohamad Nazim Jambli\setlength{\oddsidemargin}{-69pt} \begin{document}$$\Delta$$\end{document} #M3 Additive,4830,– M4 Additive + Scaled Function,3480,– 28 % Average epoch time on the CST dataset.

(4) PYK2 promotes cell proliferation and epithelial-mesenchymal transition in endometriosis by phosphorylating Snail1Mol MedApril 27, 2025Lu Liu, Lan Liu, Chenjing Yue, Shiyu Du, Jiayu Liu, Zhenhai YuRabbit anti-PYK2 (Proteintech, Cat#17592-1-AP, 1:200), Mouse anti-PYK2 (Cell Signaling Technology, 3480 S, 1:200), Rabbit anti-Snail1 (Proteintech, Cat#13099-1-AP,1:200), Mouse anti-Snail1 (Cell Signaling Technology

(5) Mechanosensitivity of macrophage polarization: comparing small molecule leukadherin-1 to substrate stiffnessFrontiers in immunologyJanuary 1, 2025Joshi H, Anaya E, Addanki A, Almgren-Bell A, Todd EM, Morley SC.Cat.#4696), JNK (OriGene Cat.#TA13291S), NF-kB (Novus Cat.# NBP2-27416SS), Pyk2 (Cell Signaling Tech. Cat.#3480S), P38 (Cell Signaling Tech. Cat.#9217), Anti-Rabbit-IgG-AF680 (AB_2535758), anti-Rabbit IgG DyLight™

(6) Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian CarcinomaCancer Research CommunicationsDecember 1, 2024Yichi Zhang, Marjaana Ojalill, Antonia Boyer, Xiao Lei Chen, Elise Tahon, Gaëtan Thivolle Lioux, Marvin Xia, Maryam Abbas, Halime Meryem Soylu, Douglas B. Flieder, et al.E6T5S, RRID: AB_3371713), DUSP1/MKP1 (35217, RRID: AB_2094225), and antibodies to Pyk2 (clone 5E2, 3480S, RRID: AB_2174093) were from Cell Signaling Technology. Mouse mAb to FAK (clone 4.47, 05-537, RRID:

(7) Differential network analysis of ROS1 inhibitors reveals lorlatinib polypharmacology through co-targeting PYK2Cell Chemical BiologyFebruary 15, 2024Yi Liao, Lily L. Remsing Remsing Rix, Xueli Li, Bin Fang, Victoria Izumi, Eric A. Welsh, Andrii Monastyrskyi, Eric B. Haura, John M. Koomen, Robert C. Doebele, et al.overnight. Antibodies included mouse IgG, anti-ROS1 mouse mAb (#3266, Cell Signaling), anti-PYK2 mouse mAb (#3480, Cell Signaling), anti-SRC mouse mAb (#2110, Cell Signaling). An aliquot of 50 μL of resuspended volume

(8) Evaluation of Tyrosine Kinase Inhibitors Loaded Injectable Hydrogels for Improving Connexin43 Gap Junction Intercellular CommunicationACS applied materials & interfacesJanuary 17, 2024Zheng L, Shi W, Liu B, Duan B, Sorgen PL.(#4695), α-phospho-Erk1/2 (T202/Y204) (#4370), α-JNK (#9252), α-phospho-JNK (T183/Y185) (#4668), α-Pyk2 (#3480S), α-Cleaved Caspase 9 (#9505S), α-rabbit-Alexa488 (#4412S), α-mouse-Alexa647 (#4410S), α-rabbit-HRP

(9) Pyk2/FAK Signaling Is Upregulated in Recurrent Glioblastoma Tumors in a C57BL/6/GL261 Glioma Implantation ModelInternational journal of molecular sciencesAugust 30, 2023Ortiz Rivera J, Velez Crespo G, Inyushin M, Kucheryavykh Y, Kucheryavykh L.Thermo Fisher Scientific, Invitrogen, MA, USA), anti-Pyk2, anti-phospho-FAK (Tyr 925), anti-FAK, and anti-Cyclin D1 (#3480, #3284, #3285, #55506 Cell Signaling, Danvers, MA, USA) antibodies, followed by the addition of the

(10) Inhibition of Pyk2 Improves Cx43 Intercalated Disc Localization, Infarct Size, and Cardiac Function in Rats With Heart FailureCirculation. Heart failureAugust 1, 2023Zheng L, Spagnol G, Gandhi DR, Sharma K, Kumar V, Patel KP, Sorgen PL.Additional antibodies used in this study include α-Src (#2123S), α-phospho-Src (Y416) (#6943S), α-Pyk2 (#3480S), α-rabbit-Alexa488 (#4412S), α-mouse-Alexa647 (#4410S), α-rabbit-HRP (#7074), α-mouse-HRP (#7076),

(11) RAGE inhibitor TTP488 (Azeliragon) suppresses metastasis in triple-negative breast cancernpj Breast CancerJuly 13, 2023Melinda Magna, Gyong Ha Hwang, Alec McIntosh, Katherine Drews-Elger, Masaru Takabatake, Adam Ikeda, Barbara J. Mera, Taekyoung Kwak, Philip Miller, Marc E. Lippman, et al.follows: phospho-Pyk2 (Y402), 1:1000, (Cell Signaling; 3291), total-Pyk2, 1:1000, (Cell Signaling; 3480), phospho-STAT3 (Y705), 1:2000, (Cell Signaling; 9145), total-STAT3, 1:1000, (Cell Signaling; 9139),

(12) The PYK2 inhibitor PF-562271 enhances the effect of temozolomide on tumor growth in a C57Bl/6-Gl261 mouse glioma modelJournal of neuro-oncologyFebruary 1, 2023Ortiz-Rivera J, Nuñez R, Kucheryavykh Y, Kucheryavykh L.Invitrogen, MA, USA), anti-Pyk2, anti-phospho-FAK (Tyr 925), anti-FAK, anti-BCL2 and anti-Cyclin D1 (#3480, #3284, #3285, #3498, #55506 Cell Signaling, Danvers, MA, USA) antibodies. Detection was performed with

(13) NBP Relieves Cardiac Injury and Reduce Oxidative Stress and Cell Apoptosis in Heart Failure Mice by Activating Nrf2/HO-1/Ca2+-SERCA2a AxisEvidence-Based Complementary and Alternative MedicineNovember 21, 2022Zhongyu Wang, Yan Zhang, Lei Wang, Chun Yang, Hongliang YangThe protein bands were visualized with SuperSignal™ West Pico PLUS Chemiluminescent Substrate (CAT#3480, Thermo Fisher Scientific, USA). The quantification of protein bands was determined by ImageJ (National

(14) Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signalingScience signalingMay 10, 2022Vasavda C, Semenza ER, Liew J, Kothari R, Dhindsa RS, Shanmukha S, Lin A, Tokhunts R, Ricco C, Snowman AM, et al.anti-phospho-Pyk2 (Y402) (Cell Signaling Technology 3291, 1:1000), mouse anti-Pyk2 (Cell Signaling Technology 3480, 1:2000), rabbit anti-phospho-Src (Y416) (Cell Signaling Technology 6943, 1:1000), rabbit anti-Src (Cell Signaling Technology

(15) Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathyMolecular neurodegenerationMay 3, 2022Brody AH, Nies SH, Guan F, Smith LM, Mukherjee B, Salazar SA, Lee S, Lam TKT, Strittmatter SM.(Thermo Fisher Scientific #44-750G, 1:1000, RRID:AB_2533743), anti-Pyk2 (Cell Signaling Technology #3480, 1:1000, RRID:AB_2174093), anti-pPyk2 Y402 (Cell Signaling Technology #3291, 1:1000, RRID:AB_2300530),

(16) L-plastin enhances NLRP3 inflammasome assembly and bleomycin-induced lung fibrosisCell reportsMarch 15, 2022Joshi H, Almgren-Bell A, Anaya EP, Todd EM, Van Dyken SJ, Seth A, McIntire KM, Singamaneni S, Sutterwala F, Morley SC.Phalloidin-AlexaFluor-488 (Invitrogen; Cat#A12379) (for F-actin) and anti-Pyk2 antibody (Cell Signaling; cat#3480S). Anti-Pyk2 antibody was detected via secondary antibody conjugated to DyLight-594 (Jackson ImmunoResearch

(17) Clusterin suppresses invasion and metastasis of testicular seminoma by upregulating COL15a1Molecular therapy. Nucleic acidsDecember 3, 2021Cui Y, Miao C, Liu S, Tang J, Zhang J, Bu H, Wang Y, Liang C, Bao M, Hou C, et al.CST); β-Catenin (8480, CST); MMP-3 (14,351, CST); FAK (71,433, CST); Phospho-FAK (8556, CST); Pyk2 (3480, CST); Phospho-PYK2 (3291, CST); and MEF2A (sc-17785, Santa Cruz). Cell culture and lentiviral infection Testicular

(18) BACE1 controls synaptic function through modulating release of synaptic vesiclesMolecular psychiatryNovember 1, 2021Das B, Singh N, Yao AY, Zhou J, He W, Hu X, Yan R.Glur2/3 [1:1000, Upstate #07-598]; GluR4 [1:1000, Upstate # 06-308]; Pyk2 [1:1000, Cell Signaling #3480]; p-Pyk2 [1:1000, Cell Signaling #3291]; Src [1:1000, Cell Signaling #2123]; p-Src (D7F2Q) [1:1000,

(19) Calmodulin Directly Interacts with the Cx43 Carboxyl-Terminus and Cytoplasmic Loop Containing Three ODDD-Linked Mutants (M147T, R148Q, and T154A) that Retain α-Helical Structure, but Exhibit Loss-of-Function and Cellular Trafficking DefectsBiomoleculesOctober 17, 2020Zheng L, Chenavas S, Kieken F, Trease A, Brownell S, Anbanandam A, Sorgen PL, Spagnol G.primary and secondary antibodies utilized in Western blot imaging are as follow: Pyk2 (Cell Signaling #3480S, 1:1,000, Danvers, USA), Pyk2 pY402 (Abcam #4800, 1:1,000, Cambridge, UK), PKCα (Cell Signaling #2056S,

(20) The non-receptor tyrosine kinase Pyk2 modulates acute locomotor effects of cocaine in D1 receptor-expressing neurons of the nucleus accumbensScientific reportsApril 20, 2020de Pins B, Montalban E, Vanhoutte P, Giralt A, Girault JA.(#AB1541, Merck KGaA), and STEP (#9069, Cell Signaling Technology) mouse monoclonal antibodies: Pyk2 (#3480, Cell Signaling Technology), DARPP-32 (1:5000; mAb6, gift from Pr. Greengard) and phosphotyrosine (#05–947,

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Pyk2 (5E2) Mouse mAb

Pyk2 (5E2) Mouse mAb from Cell Signaling Technology

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Cell Signaling Technology

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Pyk2 (5E2) Mouse mAb from Cell Signaling Technology

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