Fig 1: ADINR RNA Regulates Active Chromatin via Binding to PA1(A) RNA pull-down with six different GST-conjugated proteins (WDR5, WDR82, PA1, PTIP, RBBP5, and Menin) from the adipocyte total RNA on day 3. Only GST-PA1 specifically retrieves ADINR RNA.(B) ChIP assay of PA1 in the C/EBPα promoter region. Knockdown of ADINR RNA significantly abrogates the peaks of PA1 occupancy in the region of primers4 and primers5 (see Figure 3A). ∗∗p < 0.01, Student’s t test.(C) Affinity of seven truncated ADINR RNA fragments for GST-PA1 (in vitro binding assay). All the panels show means ± SD in three independent experiments.See also Figure S4.