MyBioSource.com's Anti-TNF Receptor II antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The Anti-TNF Receptor II antibody was generated using CD120b, TNFR2, TNFRII, and TNFRSF1B as the antigen and it reacts with Mouse, and Rat.
Description
Description: Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 1B(TNFRSF1B) detection. Tested with WB in Mouse, Rat.
Background: TNFRSF1B(Tumor Necrosis Factor Receptor Subfamily Member 1B), also known as TNFR2 or TNFBR, is a protein that in humans is encoded by the TNFRSF1B gene. The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1A. By linkage analysis, Santee and Owen Schaub(1996) confirmed the mapping of the TNFR2 gene to 1p36.3-p36.2. TNFBR(TNFR75) is the larger of the 2 TNF receptors. It is present on many cell types, especially those of myeloid origin, and is strongly expressed on stimulated T and B lymphocytes. Beltinger et al.(1996) noted that TNFR2 is the main TNF receptor found on circulating T cells and is the major mediator of autoregulatory apoptosis in CD8+ cells. TNFR2 may act with TNFR1 to kill nonlymphoid cells