MyBioSource.com's Anti-Factor VIII antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The Anti-Factor VIII antibody was generated using Coagulation Factor VIII, F8, and HEMA as the antigen and it reacts with Human.
Description
Description: Rabbit IgG polyclonal antibody for Coagulation factor VIII(F8) detection. Tested with WB in Human.
Background: Coagulation Factor VIII(FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor(AHF). By in situ hybridization, Tantravahi et al.(1986) concluded that the F8 gene is located in the proximal part of chromosome Xq28 with probes DX13 and St14 distally located. The F8 gene encodes coagulation factor VIII, a large plasma glycoprotein that functions in the blood coagulation cascade as a cofactor for the factor IXa-dependent activation of factor X(F10). Factor VIII is activated proteolytically by a variety of coagulation enzymes, including thrombin(F2). Factor VIII is tightly associated in the blood with von Willebrand factor(VWF), which serves as a protective carrier protein for factor VIII(Toole et al., 1984; Hoyer, 1994)