The alpha2B Adrenergic Receptor Antibody from MyBioSource.com is a Mouse Monoclonal antibody to ADRA2B. This antibody recognizes Mouse, and Rat antigen. The alpha2B Adrenergic Receptor Antibody has been shown to work in the following applications: Immunohistochemistry, and Western Blot.
Description
The rat alpha 2b adrenergic receptor is a G protein coupled receptor which acts through Gi2 and is responsible for Cellular communication and signal transduction. These receptors are linked to pertussis toxin-sensitive G proteins. Agonist binding leads to inhibition of adenylyl cyclase, inhibition of Ca(2+) channels and activation of K(+) channels. Recently, three distinct subtypes of alpha(2)-AR were described, alpha(2A)-AR, alpha(2B)-AR and alpha(2C)-AR. At present, it is unknown which of these alpha(2)-AR subtype(s) may regulate insulin secretion