MyBioSource.com's ch-Alk2 Antibody is a Sheep Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The ch-Alk2 Antibody was generated using ActRIA, ACVR1, ACVR1A, and ALK2 as the antigen and it reacts with Chicken/Bird.
Description
Activin Receptor-Like Kinase 2 is a member of the superfamily of type I receptors for transforming growth factor- (TGF-). This receptor binds both activin and bone morphogenic proteins (BMPs). In mice, these receptors are expressed mainly in the extraembryonic visceral endoderm before gastrulation and later in both embryonic and extraembryonic cells during gastrulation. Also, it has been shown that ALK2 associates with and phosphorylates Smad1 and also regulated Smad5 and Smad8 phosphorylation. Additionally, it induces the Tlx2 promoter in the absense of BMP7