MyBioSource.com's Transport complex Sec-23 is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunoprecipitation, and Western Blot.
Description
The regulation of intracellular vesicular trafficking is mediated by specific families of proteins that are involved in vesicular budding, translocation, and fusion with target membranes. The protein trafficking between endoplasmic reticulum (ER) and Golgi apparatus is mediated by two distinct membrane coat complexes, COPI and COPII (1). Two Coat protein II (COPII) proteins are necessary to generate secretory vesicles at the endoplasmic reticulum. COPI consist of 7 protein subunits including á, 1, ä, å, ä, æ. COPI is also responsible for the retrograde golgi to ER transport f dilysine-tagged proteins (2). Sec23A is a functional human counter part of the yeast COPII component Sec23p which suggests that it plays similar role in the mammalian protein export from ER. Both Sec 23 isoforms (Sec23A and Sec23B) have similar molecular weight 85 kDa and are co-expressed in many human tissues at varying levels of expression. In yeast, the Sec24p protein is the only COPII component in which two close orthologues have been identified. Sec-23p is a component of coat protein II (COPII) coated vesicles involved in protein export from the endoplasmic reticulum (Mizoguchi et. al., 2000). The COPII is required for the vesicle budding from the endoplasmic reticulum and is consist of two heterodimeric subcomplexes, Sec23p/Sec24p and Sec13p/Sec31p and a small GTPase Ser1p (Higashio et al., 2000). Recent data also suggest that Sec23p/Sec24p complexes are in addition to its role in the shaping up of the vesicle, the Sec23-24p complex may be implicated in cargo selection and trafficking of the amount of cargo with in the cells. Two Sec23p antibodies were generated in rabbits against synthetic peptides from the unique sequence to Sec23 protein. MyBioSource, will also provide Western blot positive controls for human Sec23 in ready-to-use buffer for easy identification of Sec23 protein in samples. Limited quantity of antigenic peptide is also available. Please enquire for their availability before ordering