The R spondin1 antibody from MyBioSource.com is a Mouse Monoclonal antibody to Miscellaneous, R-Spondin 1, R-spondin1, RSPO, RSPO1, and RSPONDIN. This antibody recognizes Human antigen. The R spondin1 antibody has been shown to work in the following applications: ELISA, and Western Blot.
Description
Mouse monoclonal R spondin1 antibody
R spondin1 is a member of the R-spondin family and a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. It is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination