MyBioSource.com's Anti-TORC2 antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The Anti-TORC2 antibody was generated using Crtc2, and TORC2 as the antigen and it reacts with Human.
Description
Description: Rabbit IgG polyclonal antibody for CREB-regulated transcription coactivator 2(CRTC2) detection. Tested with WB in Human.
Background: CRTC2(CREB-Regulated Transcription Coactivator 2), also known as TORC2, is a protein that in humans is encoded by the CRTC2 gene. The International Radiation Hybrid Mapping Consortium mapped the CRTC2 gene to chromosome 1. By cotransfection of TORC2 and reporter genes in HeLa cells, Iourgenko et al.(2003) found that TORC2 potently activated expression of genes driven by the IL8 promoter or a promoter carrying multiple CRE-like sequences. Liu et al.(2008) demonstrated that a fasting-inducible switch, consisting of the histone acetyltransferase p300 and the nutrient-sensing deacetylase sirtuin-1(SIRT1), maintains energy balance in mice through the sequential induction of CRTC2 and FOXO1. Using mice and primary mouse hepatocytes, Wang et al.(2009) found that Crtc2 functioned as a dual sensor for endoplasmic reticulum(ER) stress and fasting signals