MyBioSource.com's DPC4 antibody is a Mouse monoclonal antibody. The DPC4 antibody was generated using DPC4, and SMAD4 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Immunocytochemistry, and Western Blot.
Description
Mouse monoclonal DPC4 antibody
SMAD4 plays a pivotal role in signal transduction of the transforming growth factor beta superfamily cytokines by mediating transcriptional activation of target genes. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Mutational inactivation of SMAD4 causes TGF-beta unresponsiveness and gave a basis for understanding the physiologic role of this gene in tumorigenesis. Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases