MyBioSource.com's c-Jun, Monoclonal Antibody, Rabbit is a Rabbit monoclonal antibody. The c-Jun, Monoclonal Antibody, Rabbit was generated using c-Jun, cJun, and Jun as the antigen. It reacts with Human, Mouse, Rat, Non-Human Primate, and Porcine. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Description: c-Jun is a component of the transcription factor AP-1, which binds and activates transcription at TRE/AP-1 elements. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73 (1,2). Extracellular signals including growth factors, transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun-dependent transcription. Mutation of Ser63/73 renders c-Jun nonresponsive to mitogenic and stress-induced signaling pathways. The MAP kinase homologue SAPK/JNK binds to the amino-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. In addition, the activity of SAPK/JNK is stimulated by the same signals that activate c-Jun (3,4). c-Jun also plays a role in Neuropathic Pain