BiP (C50B12) Rabbit mAb (PE Conjugate) 14464S from Cell Signaling Technology

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Int J Oral Sci
April 01 2025

Fig 1: Monocyte-derived macrophages in favor of pro-inflammatory phenotype in corticotomy. a Representative 3D reconstruction images show the modeling method of TM + CO group. b Experimental design for tamoxifen‐treated CX3CR1CreERT2; R26GFP mice to deplete GFP+ monocyte-derived macrophages. c FACS analysis of CD45+F4/80+CD11b+Ly6C+ pro-inflammatory macrophages and CD45+F4/80+CD11b+CD206+ reparative macrophages in murine periodontal tissues from BLANK, TM and TM + CO groups. d FACS analysis of GFP+CD45+F4/80+CD11b+ resident and GFP−CD45+F4/80+CD11b+ monocyte-derived macrophages in murine periodontal tissues from BLANK, TM and TM + CO groups. e FACS analysis of CD45+F4/80+CD11b+Ly6C+ pro-inflammatory macrophages and CD45+F4/80+CD11b+CD206+ reparative macrophages in GFP− monocyte-derived macrophages or GFP+ resident macrophages in murine periodontal tissues from BLANK, TM and TM + CO groups. f, g Representative immunofluorescence staining images and quantification of F4/80+ (red) BiP+ (white) GFP− cells in murine periodontal tissues. Scale bars, 50 μm. h FACS analysis of BiP+ macrophages in GFP−CD45+F4/80+CD11b+ monocyte-derived macrophages in murine periodontal tissues from BLANK, TM and TM + CO groups. Data represent mean ± SD. N = 5. *P < 0.05, **P < 0.01. TM tooth movement, TM + CO corticotomy-assisted orthodontic tooth movement
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Int J Oral Sci
April 01 2025

Fig 2: Corticotomy triggers ATF6 branch of the UPR in macrophages during OTM. a Experimental design: 8-week-old male C57B/L6 mice were randomly divided into BLANK, TM and TM + CO groups. After 7 days of OTM, the maxillae were harvested for alveolar bone lysates preparation. b, c Western blot analysis and quantification of ATF6 p50, ATF6, p-IRE1α, IRE1α, p-PERK, PERK and BiP protein expression in BMDMs with stimulation of alveolar bone lysates from Blank, TM and TM + CO mice. d Representative immunofluorescence staining images of ATF6+ (green) F4/80+ (red) cells with stimulation of alveolar bone lysates in vitro. Scale bars, 20 μm. e, f Western blot analysis and quantification of BiP, ATF6 and ATF6 p50 protein expression in murine periodontal tissues acquired 7 days after TM and TM + CO treatment. g, h Representative immunofluorescence staining images and quantification of ATF6+ (green) F4/80+ (red) cells in murine periodontal tissues acquired 7 days after TM and TM + CO treatment. Scale bars, 50 μm. Data represent mean ± SD. N = 3 or 4. *P < 0.05, **P < 0.01. ns no significance, TM tooth movement, TM + CO corticotomy-assisted orthodontic tooth movement

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BiP (C50B12) Rabbit mAb (PE Conjugate)

The BiP (C50B12) Rabbit mAb (PE Conjugate) Antibody from Cell Signaling Technology is a Rabbit Monoclonal antibody to HSPA5. This antibody recognizes Homo Sapiens, Human, and Mouse antigen. The BiP (C50B12) Rabbit mAb (PE Conjugate) Antibody has been shown to work in the following applications: Flow Cytometry.

Description

BiP (C50B12) Rabbit mAb (PE Conjugate) detects endogenous levels of total BiP protein

Int J Oral Sci

Int J Oral Sci

BiP (C50B12) Rabbit mAb (PE Conjugate) from Cell Signaling Technology

Description

Cell Signaling Technology

Citations (2)

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BiP (C50B12) Rabbit mAb (PE Conjugate) from Cell Signaling Technology

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