The SDF1 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CXCL12. This antibody recognizes Human antigen. The SDF1 Polyclonal Antibody has been shown to work in the following applications: Immunohistochemistry, and Western Blot.
Description
The stromal cell derived factor 1 (SDF1, CXCL12) is a small, proinflammatory chemoattractant cytokine that regulates leukocyte trafficking through interactions with its cognate 7transmembrane G proteincoupled receptors (1). The SDF1 receptor, CXCR4, also serves as a coreceptor for the entry of human immunodeficiency virus into target cells (2). SDF1 may regulate homing and maintenance of CXCR4expressing stem or progenitor cells, including embryonic and many somatic stem cells (3,4). Many cancer cells express CXCR4, suggesting that SDF1 plays a role in cancer metastasis (5,6). Alternative splicing and differential processing during maturation produce a pair of SDF1 isoforms (SDF1alpha and SDF1beta) that have different properties and biological activities (7). Additional isoforms of SDF1 have been reported (8,9)