The OGT Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen. The OGT Polyclonal Antibody has been shown to work in the following applications: Immunohistochemistry, and Western Blot.
Description
O-GlcNAcylation is a posttranslational modification where beta-D-N-acetylglucosamine (GlcNAc) is covalently linked to cytoplasmic and nuclear proteins at serine or threonine residues (1,2). This modification is important in many cellular processes including metabolism, cell growth and morphogenesis, apoptosis, and transcription (2,3), and research studies have implicated this modification in cancer (1). The reversible protein modification by O-GlcNAc, which has been suggested to be a nutrient and stress sensor, is catalyzed by two highly conserved enzymes, OGlcNAc transferase (OGT) and OGlcNAcase (OGA) (4)