The FZD7 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to FZD7. This antibody recognizes Human, Mouse, and Rat antigen. The FZD7 Polyclonal Antibody has been shown to work in the following applications: Western Blot.
Description
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas