The MRE11A Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to MRE11, and MRE11A homolog A, double strand break repair nuclease. This antibody recognizes Human, Mouse, and Rat antigen. The MRE11A Polyclonal Antibody has been shown to work in the following applications: Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms