The TP53 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Antigen NY-CO-13, bbl, LFS1, Mutant p53, TP53, and tumor protein p53. This antibody recognizes Human, and Mouse antigen. The TP53 Polyclonal Antibody has been shown to work in the following applications: Immunofluorescence, and Western Blot.
Description
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity