The Tuberin/TSC2 Rabbit pab Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to TSC2. This antibody recognizes Human antigen. The Tuberin/TSC2 Rabbit pab Antibody has been shown to work in the following applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Rabbit polyclonal to Human Tuberin/TSC2
Tuberin is a product of the TSC2 tumor suppressor gene and an important regulator of cell proliferation and tumor development (1). Mutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors (2). Tuberin is directly phosphorylated at Thr1462 by Akt/PKB (3). Phosphorylation at Thr1462 and Tyr1571 regulates tuberin-hamartin complexes and tuberin activity (3-5). In addition, tuberin inhibits the mammalian target of rapamycin (mTOR), which promotes inhibition of p70 S6 kinase, activation of eukaryotic initiation factor 4E binding protein 1 (4E-BP1, an inhibitor of translation initiation), and eventual inhibition of translation (3,6,7)