Cdc6 (C42F7) Rabbit mAb 3387S from Cell Signaling Technology

Product Specs
ItemCdc6 (C42F7) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number3387S
Quantity100 µl
ApplicationsW
ReactivityH, M, R, Hm, Mk
TargetCdc6
HostRabbit
NCBI Gene AliasesCDC18L, HsCDC18, HsCDC6, MGORS5
ClonalityMonoclonal
NCBI Full Gene Namecell division cycle 6
Research AreaCell Cycle / Checkpoint Control
IsotypeIgG
CloneC42F7
Molecular Weight62

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) A Combination of Xanthohumol and Ursolic Acid in the Diet Leads to Synergistic Inhibition of Prostate Cancer ProgressionMolecular CarcinogenesisFebruary 10, 2026Rachel Clark, Achinto Saha, G. Lavender Hackman, Chelsea A. Friedman, Ruggiero Gorgoglione, Stefano Tiziani, John DiGiovanni(Cell Signaling, 9145), STAT3 (Cell Signaling, 9139), cyclin D1 (Cell Signaling, 2922), cdc6 (Cell Signaling, 3387), p‐RbS807/811 (Cell Signaling, 9308), Rb (Invitrogen, MA5‐11387), c‐MYC (Cell Signaling, 5605), ATF4

(2) Putrescine functions as a metabolic checkpoint in replication stress-induced senescenceCellular and Molecular Life SciencesNovember 19, 2025Theodora Vasilogiannakopoulou, Olga Begou, Christina Simoglou Karali, Georgia Efthymiou, Maria Roubelakis, Vassilis Gorgoulis, Kalliopi K. Gkouskou, Helen Gika, Aristides G. EliopoulosFor immunoblotting, the following primary antibodies were used: CDC6 (dilution 1:000, Cell Signaling #3387S), p53 (dilution 1:500, Santa Cruz #47698), MYC (dilution 1:1000, Cell Signaling #5605), ODC1 (dilution

(3) BRCA2 reversion mutation-independent resistance to PARP inhibition through impaired DNA prereplication complex functionProc Natl Acad Sci U S AJune 10, 2025Kyrie Pappas, Matteo Ferrari, Perianne Smith, Subhiksha Nandakumar, Zahra Khan, Serina B. Young, Justin LaClair, Marco Vincenzo Russo, Emmet Huang-Hobbs, Nikolaus Schultz, et al.(S345),"2348S, Cell Signaling Technology","1:1,000" CHK1,"2360S, Cell Signaling Technology","1:1,000" Cdc6,"3387S, Cell Signaling Technology","1:1,000" Geminin,"ab246509, Abcam","1:1,000" Cdt1,"PA5-42861, Invitrogen","1:1,000" γH2AX,"IF:

(4) The class II myosin MYH4 safeguards genome integrity and suppresses tumor progressionJ Clin InvestJune 2, 2025Jayashree Thatte, Ana Moisés da Silva, Judit Börcsök, Thorkell Gudjónsson, Jan Benada, Xin Li, Muthiah Bose, Hanneke van der Gulden, Ji-Ying Song, Renée Menezes, et al.MAB1501), rabbit anti–histone H4 (Millipore, 05-858), rabbit anti-CDC6 (Cell Signaling Technology, 3387S), and rabbit anti-CDT1 (Cell Signaling Technology, 8064S). Synergy analysis A dose-response matrix

(5) LINC01235 Promotes Clonal Evolution through DNA Replication Licensing‐Induced Chromosomal Instability in Breast CancerAdvanced ScienceFebruary 14, 2025Qi Zhang, Xuliren Wang, Zhibo Shao, Yi Zhang, Liyi Zhang, Ming Chen, Xujie Zhou, Han Zhu, Yue Zhou, Xinya Lu, et al.MCM7 (Cell Signaling, 4018, 1:1000), CDC45 (Cell Signaling, 11 881, 1:1000), CDC6 (Cell Signaling, 3387, 1:1000), PCNA (Cell Signaling, 13 110, 1:1000), Phospho‐CDC2 (Cell Signaling, 4539, 1:1000), phospho‐RB

(6) Single-cell analysis reveals host S phase drives large T antigen expression during BK polyomavirus infectionPLOS PathogensDecember 5, 2024Jason M. Needham, Sarah E. Perritt, Sunnie R. ThompsonRRID:AB_2783865, phospho-ATMS1981: AbCam ab81292 RRID:AB_1640207, Cdc6: Cell Signaling Technologies 3387T RRID:AB_2078525, Cdt1: Cell Signaling Technologies 8064S RRID:AB_10896851, Geminin: Abcam ab195047 RRID:AB_2832993,

(7) Y-box binding protein 1/cyclin A1 axis specifically promotes cell cycle progression at G(2)/M phase in ovarian cancerScientific reportsSeptember 17, 2024Murakami Y, Katsuchi D, Matsumoto T, Kanazawa K, Shibata T, Kawahara A, Akiba J, Yanaihara N, Okamoto A, Itamochi H, et al.cyclin B1 (cat. no. #4138), cyclin D1 (cat. no. #55506), cyclin E (cat. no. #4129), and CDC6 (cat. no. #3387), PKCα (cat. no. #59754), p-PKCα/β II (cat. no. #9375), AKT (cat. no. #9272) p-AKT (cat. no. #4060),

(8) Integrative analysis of the role of BOLA2B in human pan-cancerFrontiers in geneticsJanuary 1, 2023Liang M, Fei Y, Wang Y, Chen W, Liu Z, Xu D, Shen H, Zhou H, Tang J.26080-1-AP), tubulin (Proteintech, #11224-1-AP), CDK6 (Cell Signaling Technology [CST], #13331), cdc6 (CST, #3387), cyclin B1 (CST, #12231), cyclin D1 (CST, #55506), cyclin E1 (CST, #20808), p21 (CST, #2947), p-AKT

(9) XIAP promotes melanoma growth by inducing tumour neutrophil infiltrationEMBO reportsJune 7, 2022Daoud M, Broxtermann PN, Schorn F, Werthenbach JP, Seeger JM, Schiffmann LM, Brinkmann K, Vucic D, Tüting T, Mauch C, et al.antibodies against XIAP (#610763, BD Biosciences or # M044‐3, MBL), TAB1 (#3226, Cell Signaling), TAB1 (#3387, ProSci), RIPK2 (#4142, Cell Signaling), β‐Actin (#A5441, Sigma), cIAP1 (#ALX‐803‐335, Enzo), RIPK1

(10) NELL2-cdc42 signaling regulates BAF complexes and Ewing sarcoma cell growthCell reportsJuly 6, 2021Jayabal P, Zhou F, Lei X, Ma X, Blackman B, Weintraub ST, Houghton PJ, Shiio Y.Cell Signaling Technologies); mouse monoclonal anti-Rpb1 (2629, Cell Signaling Technologies); rabbit monoclonal anti-cdc6 (3387, Cell Signaling Technologies); rabbit monoclonal anti-caveolin-1 (3267, Cell Signaling Technologies);

(11) Musashi1 Contribution to Glioblastoma Development via Regulation of a Network of DNA Replication, Cell Cycle and Division GenesCancersMarch 24, 2021Baroni M, Yi C, Choudhary S, Lei X, Kosti A, Grieshober D, Velasco M, Qiao M, Burns SS, Araujo PR, et al.USA GTX103193), AURKA (Cell Signaling, 14475S), CDK2 (Cell Signaling, 2546S), CDC6 (Cell Signaling, 3387S), E2F8 (GeneTex, GTX 112299) and β-tubulin (Sigma-Aldrich, St Louis, MO, USA). Horseradish peroxidase

(12) BRG1 knockdown inhibits proliferation through multiple cellular pathways in prostate cancerClinical epigeneticsFebruary 17, 2021Giles KA, Gould CM, Achinger-Kawecka J, Page SG, Kafer GR, Rogers S, Luu PL, Cesare AJ, Clark SJ, Taberlay PC.BRG1 (Santa Cruz, sc-10768X), GAPDH (Ambion, AM4300), CHK1 (CST, 2360S), ORC6 (CST, 4737S), CDC6 (CST, 3387S), MCM5 (abcam, ab17967), AR (CST, D6F11), FOXA1 (CST, E7E8W), Vinculin (Sigma-Aldrich, V9131), H2A (CST,

(13) BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR DependencyCancer ResearchSeptember 15, 2020Manav Gupta et al.(2360S), pCHK1 (2341S), Histone H3 (4499S), BAF155 (11956S), BAF170 (12760S), ARID1A (12354S), CDC6 (3387T), ORC1 (4731T), RPA1 (2267S), RPA2 (52448S), BAF47 (91735S), LKB1 (3047S), KEAP1 (8047S). TOPBP1 was

(14) Antagonism between the RNA-binding protein Musashi1 and miR-137 and its potential impact on neurogenesis and glioblastoma developmentRNA (New York, N.Y.)July 1, 2019Velasco MX, Kosti A, Guardia GDA, Santos MC, Tegge A, Qiao M, Correa BRS, Hernández G, Kokovay E, Galante PAF, et al.milk-TBST); anti-NEFL1 (Cell signaling, #2835; 1:1000 in 5% milk-TBST), Anti-CDC6 (C42F7) (Cell signaling, #3387; 1:500 in 5% BSA-TBST); Anti-NRAS (27H5) (Cell signaling, #3339; 1:1000 in 5% BSA-TBST); anti-α Tubulin

(15) Identification of genetic variants for clinical management of familial colorectal tumorsBMC Medical GeneticsDecember 1, 2018Mev Dominguez-Valentin, Sigve Nakken, HÃ©lÃ¨ne Tubeuf, Daniel Vodak, Per Olaf EkstrÃ¸m, Anke M. Nissen, Monika Morak, Elke Holinski-Feder, Alexandra Martins, PÃ¥l MÃ¸ller, et al.rs1042821, rs3219484, rs1805794, rs1044009, rs2228006, rs5744934, rs5744751, rs4796033, rs1042522",24 3387,na,"CDKN2AN M_000077: c.442G > A, p.A148T (rs3731249)","rs459552, rs659243, rs1801516, rs2240308rs2070094

(16) The prognostic significance of Cdc6 and Cdt1 in breast cancerScientific ReportsApril 20, 2017Ravikiran Mahadevappa, Henrique Neves, Shun Ming Yuen, Yuchen Bai, Cian M. McCrudden, Hiu Fung Yuen, Qing Wen, Shu Dong Zhang, Hang Fai Kwokovernight with primary anti-Cdt1 antibody (#8064 Cell Signaling Technology) (1:500) or anti-Cdc6 antibody (#3387 cell signaling technology) (1:500) and primary anti-β-actin antibody (Santa Cruz) (1:5000). Blot was

(17) Targeting DNA Damage Response in Prostate Cancer by Inhibiting Androgen Receptor-CDC6-ATR-Chk1 SignalingCell reportsFebruary 21, 2017Karanika S, Karantanos T, Li L, Wang J, Park S, Yang G, Zuo X, Song JH, Maity SN, Manyam GC, et al.AZD7762 was then added for 24 hours. Synchronization was achieved as above. Antibodies against CDC6 (3387), ATR (2790), P-ATR Ser428 (2853), Chk1 (2360), P-Chk1Ser317 (12302), Cdc25C (4688), P-Cdc25C Ser216

(18) Two subunits of human ORC are dispensable for DNA replication and proliferationeLifeDecember 1, 2016Shibata E, Kiran M, Shibata Y, Singh S, Kiran S, Dutta A.(Machida et al., 2005), ORC1 (4731, Cell Signaling Technology, Danvers, MA, RRID:AB_2157583), CDC6 (3387, Cell Signaling Technology, RRID:AB_2078525), p-Chk1 (2341, Cell Signaling Technology, RRID:AB_330023),

(19) WHSC1L1 drives cell cycle progression through transcriptional regulation of CDC6 and CDK2 in squamous cell carcinoma of the head and neckOncotargetJuly 5, 2016Saloura V, Vougiouklakis T, Zewde M, Kiyotani K, Park JH, Gao G, Karrison T, Lingen M, Nakamura Y, Hamamoto R.dilution: 1:5000), anti-CDK2 (#2546, Cell Signaling Technology, Danvers, MA, dilution: 1:1000), anti-CDC6 (#3387, Cell Signaling Technology, Danvers, MA, 1:1000), anti-ACTB (A5441, Sigma-Aldrich, St. Louis, MO, dilution:

(20) Silencing of RTKN2 by siRNA suppresses proliferation, and induces G1 arrest and apoptosis in human bladder cancer cellsMolecular Medicine ReportsJune 1, 2016YI-XIANG LIAO, JIN-MIN ZENG, JIA-JIE ZHOU, GUANG-HUA YANG, KUN DING, XIAN-JUE ZHANGdeviation. RTKN2, Rhotekin 2; NC, negative control; siRNA, small interfering RNA. monoclonal cat. no., 3387 dilution, 1:1,000; Cell Signaling Technology, Inc.,) for 2 h at 25˚C, or anti‑GAPDH antibody (cat. no.

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Cdc6 (C42F7) Rabbit mAb

Cdc6 (C42F7) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Cdc6 (C42F7) Rabbit mAb from Cell Signaling Technology

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