CD34 Antibody (QBEnd/10) [Alexa Fluor® 488] from Novus Biologicals, a Bio-Techne Brand

Available conjugates: Available conjugates: Alexa Fluor 350, Alexa Fluor 405, DyLight 680, Alexa Fluor 647, FITC, Alexa Fluor 532, DyLight 350, HRP, DyLight 755, Biotin, DyLight 594, PerCP, Alexa Fluor 594, DyLight 405, Janelia Fluor 549, DyLight 488, DyLight 650, Alexa Fluor 488

Specificity: This MAb recognizes a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34. On the basis of differential sensitivity to degradation by specific enzymes, epitopes of monoclonal antibodies to CD34 are classified into three main categories, class I, class II and class III. It is a class II antibody whose epitope is resistant to neuraminidase but sensitive to glycoprotease and chymopapain. CD34 expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, CD34 is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. Its expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells express this molecule more than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposi s sarcoma, but with a lower specificity.

Sizes Available: 0.1 ml