p53 Antibody (DO-7) [Alexa Fluor® 700] NBP2-34605AF700 from Novus Biologicals, a Bio-Techne Brand

Product Specs
Itemp53 Antibody (DO-7) [Alexa Fluor® 700]
CompanyNovus Biologicals, a Bio-Techne Brand
Price $559.00Supplier Page View Company Product Page
Catalog NumberNBP2-34605AF700
Quantity0.1 ml
ApplicationsImmunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,CyTOF-ready
Conjugate/TagAlexa Fluor 700
Format50mM Sodium Borate
ReactivityBovine,Human,Monkey
Targetp53
IsotypeIgG2b Kappa
CloneDO-7
HostMouse
ImmunogenRecombinant human wild type p53 protein expressed in E. coli. (Uniprot: P04637)
ClonalityMonoclonal
PurityProtein A or G purified
Research AreaApoptosis, Cancer, Cell Cycle and Replication, Cellular Markers, Checkpoint signaling, Core ESC Like Genes, DNA Double Strand Break Repair, DNA Repair, HIF Target Genes, Hypoxia, Neuroscience, Neurotransmission, p53 Pathway, Stem Cell Markers, Transcription Factors and Regulators, Tumor Suppressors
Antibody TypePrimary Antibodies
StorageStore at 4C in the dark
NCBI Full Gene Nametumor protein p53
NCBI Gene AliasesBCC7, BMFS5, LFS1, P53, TRP53

Specifications/Features

Available conjugates: Available conjugates: Alexa Fluor 700

Specificity: Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. Its epitope maps within the N-terminus (aa 37-45) of p53. Monoclonal antibody PAb1801 does not block the binding of DO-7 monoclonal antibody to p53 in an ELISA test. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

Sizes Available: 0.1 ml

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