MAGEA1 Antibody (SPM282) [Alexa Fluor® 405] NBP2-34754AF405 from Novus Biologicals, a Bio-Techne Brand

Product Specs
ItemMAGEA1 Antibody (SPM282) [Alexa Fluor® 405]
CompanyNovus Biologicals, a Bio-Techne Brand
Price $539.00Supplier Page View Company Product Page
Catalog NumberNBP2-34754AF405
Quantity0.1 ml
ApplicationsFlow Cytometry,Immunohistochemistry,Immunohistochemistry-Paraffin,Flow (Intracellular),CyTOF-ready,Immunocytochemistry/ Immunofluorescence
Conjugate/TagAlexa Fluor 405
Format50mM Sodium Borate
ReactivityCanine,Human,Rat
PurityProtein A or G purified
TargetMAGEA1
IsotypeIgG1 Kappa
CloneSPM282
HostMouse
Antibody TypePrimary Antibodies
ImmunogenHuman MAGEA1 full length recombinant protein (Uniprot: P43355)
ClonalityMonoclonal
Research AreaApoptosis, Cancer, Melanoma Cell Markers, Tumor Suppressors
StorageStore at 4C in the dark
NCBI Full Gene NameMAGE family member A1
NCBI Gene AliasesCT1.1, MAGE1

Specifications/Features

Available conjugates: Available conjugates: Alexa Fluor 405, Allophycocyanin, Biotin, DyLight 680, Alexa Fluor 647

Specificity: Recognizes a protein of 42-46kDa, identified MAGEA1 (MAGE-1). This monoclonal antibody does not cross-react with MAGE-2, -3, -4, -6 -9, -10, -or -12 protein. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGEA1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.

Sizes Available: 0.1 ml

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