Supplier Page from Novus Biologicals, a Bio-Techne Brand for Integrin beta 4/CD104 Antibody (UM-A9) [Alexa Fluor® 647]
Available conjugates: Available conjugates: PE/Atto594, Janelia Fluor 669, Alexa Fluor 647, mFluor Violet 610 SE, DyLight 650, Allophycocyanin, Biotin, DyLight 680, Alexa Fluor 594, Janelia Fluor 549, DyLight 488, DyLight 755Specificity: Recognizes a protein of 205kDa, which is identified as integrin beta-4 (ITGB4). Its epitope is localized in the extracellular domain of ITGB4 protein. Integrins are heterodimers comprised of alpha and beta subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta-4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.Sizes Available: 0.1 ml