CD20 Antibody (B9E9) [Alexa Fluor® 647] from Novus Biologicals, a Bio-Techne Brand

Available conjugates: Available conjugates: Alexa Fluor 647, Alexa Fluor 350, DyLight 594, mFluor Violet 500 SE, FITC, DyLight 680, mFluor Violet 450 SE, DyLight 350, PE/Cy5.5, DyLight 755, PE/Cy7, Janelia Fluor 669, Alexa Fluor 594, PerCP, DyLight 650, Alexa Fluor 750, Janelia Fluor 646

Specificity: Recognizes a protein of 33-37kDa, identified as CD20 (Workshop V; Code CD20.12). B9E9 recognizes extracellular domain of CD20. The epitope is similar to or identical to that recognized by other CD20 antibodies including Leu-16 and B1. This monoclonal antibody can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood, B cell localization in tissues and B lymphocyte purification by immunosorbent methods. CD20 is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. Protein passes through the membrane 4 times with both ends in cytoplasm and exposes one short and one longer loop to the external environment. CD20 is not glycosylated in resting B cells and its cytoplasmic domains are differentially phosphorylated upon activation. It acts as a calcium channel involved in B-cell activation and cell cycle progression.

Sizes Available: 0.1 ml