Supplier Page from Novus Biologicals, a Bio-Techne Brand for Cyclin D1 Antibody (DCS-6) [Alexa Fluor® 488]
Available conjugates: Available conjugates: mFluor Violet 500 SE, DyLight 350, HRP, Allophycocyanin, Alexa Fluor 700, Alexa Fluor 594, Alexa Fluor 488, DyLight 488, Alexa Fluor 750, Janelia Fluor 646Specificity: Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). About 40% of breast carcinomas are positive for Cyclin D1. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.Sizes Available: 0.1 ml