Lck (D88) XP ® Rabbit mAb 2984S from Cell Signaling Technology

Product Specs
ItemLck (D88) XP ® Rabbit mAb
CompanyCell Signaling Technology
Price $371.00 Inquire
Catalog Number2984S
Quantity100 µl
ApplicationsW, W-S, IHC-P, IF-IC, FC-FP
ReactivityH, M, R
TargetLck
HostRabbit
NCBI Gene AliasesIMD22, LSK, YT16, p56lck, pp58lck
ClonalityMonoclonal
NCBI Full Gene NameLCK proto-oncogene, Src family tyrosine kinase
Research AreaImmunology and Inflammation
IsotypeIgG
CloneD88
Molecular Weight56

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) CD147 regulates CD8+ T cell cytotoxic activity by facilitating phosphorylation and subsequent recruitment of proximal TCR signaling kinasesiScienceFebruary 20, 2026Taiyu Shu, Dan Wang, Hao Wang, Jie Zou, Heyao Qin, Xue Liang, Hongyong Cui, Qian He, Yuxi Zhang, Jianli JiangPhospho-LYN (Tyr397)/LCK (Tyr394)/HCK (Tyr411)/BLK (Tyr389) (E5L3D) Rabbit mAb,CST,Cat# 70926; RRID: AB_2924371 Lck (D88) XP® Rabbit mAb,CST,Cat# 2984; RRID: AB_2136313 Phospho-Lck (Tyr505) Antibody,CST,Cat# 2751; RRID: AB_330446 Phospho-Zap-70 (Tyr319)/Syk (Tyr352) Antibody

(2) XAF1 is secreted from stressed tumor cells to activate T cell-mediated tumor surveillance via Lck-ERK signalingNeoplasiaJanuary 1, 2025Jieun Ahn, Seung-Hun Jang, Sungchan Jang, Ji-Hye Yoon, Min-Goo Lee, Sung-Gil ChiERK1/2 (#4696), GFP (sc-9996), GST (sc-33613), phosphor-Tyr (sc-7020), phospho-Src (Y416) (#6943), Lck (#2984) and β-Tubulin (T0198), which were purchased from Cell Signaling Technology, Santa Cruz Biotechnology,

(3) Chlorogenic acid compounds from sweetpotato (Ipomoea batatas L.) leaves facilitate megakaryocyte differentiation and thrombocytopoiesis via PI3K/AKT pathwayFrontiers in PharmacologyAugust 21, 2024Yi Zhang, Lu Zhao, Liping Wang, Ruixue Yue, Hong Zhu, Wenting Zhang, Jian Sun, Zifeng Zhang, Daifu MaTNF-α (AYE-3565), M-CSF (AYE-2237), TPO (AYE-29938), IL-2 (AYE-39484), IL-10 (AYE-34262), TGF-β (AYE-2984) were purchased from Xinle (Shanghai, China). Giemsa solution and phalloidin staining were purchased

(4) Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networksImmunityFebruary 13, 2024Carla A. Jaeger-Ruckstuhl, Yun Lo, Elena Fulton, Olivia G. Waltner, Tamer B. Shabaneh, Sylvain Simon, Pranav V. Muthuraman, Colin E. Correnti, Oliver J. Newsom, Ian A. Engstrom, et al.[Tyr591],Abcam,Cat#ab41436; RRID: AB_777913 Anti-human Lck (clone D88) XP Rabbit mAb,Cell Signaling Technology,Cat#2984; RRID: AB_2136313 Anti-human phospho Lck [Tyr394] (clone E5L3D) Rabbit mAb,Cell Signaling Technology,Cat#70926;

(5) A long-term high-fat diet influences brain damage and is linked to the activation of HIF-1α/AMPK/mTOR/p70S6K signallingFrontiers in neuroscienceJanuary 1, 2022Chen F, Yi WM, Wang SY, Yuan MH, Wen J, Li HY, Zou Q, Liu S, Cai ZY.incubated with primary antibodies [HIF-1α (1:1000, Proteintech Cat No. 20960-1-AP), mTOR (1:1000, CST, 2984), p-mTOR (Ser2448) (1:1000, CST, 5536), p70S6 kinase (1:1000, CST, 9202), LC3A/B, Beclin-1, Atg3 212

(6) Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitationMolecular cancerJune 11, 2021Weiße J, Rosemann J, Müller L, Kappler M, Eckert AW, Glaß M, Misiak D, Hüttelmaier S, Ballhausen WG, Hatzfeld M, et al.tissues from four patients was analyzed using a 1:200 dilution of a monoclonal rabbit anti-Lck antibody (#2984S, Cell Signaling, Danvers) according to the manufacturer’s recommendations. Correlation of LCK expression

(7) Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cellsNature communicationsJanuary 23, 2020Fu S, He K, Tian C, Sun H, Zhu C, Bai S, Liu J, Wu Q, Xie D, Yue T, et al.SAB4300118, 1:1000 dilution), P-LAT (Cell signaling Tech 3584, 1:1000 dilution), LCK (Cell signaling Tech 2984, 1:1000 dilution), LAT (Cell signaling Tech 9166, 1:1000 dilution), and β-actin (Transgen Biotech HC201-02,

(8) Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damageNature communicationsDecember 3, 2019Bolderson E, Burgess JT, Li J, Gandhi NS, Boucher D, Croft LV, Beard S, Plowman JJ, Suraweera A, Adams MN, et al.1:500 for WB), anti-LC3B (2775, Cell Signalling Technologies, 1:1000 for WB), anti-phospho-p53 ser15 (2984, Cell Signalling Technology, 1:1000 for WB), anti-β-actin (612656, BD Biosciences, 1:2000 for WB). Fluorescent

(9) Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cellseLifeJuly 8, 2019Brian BF 4th, Jolicoeur AS, Guerrero CR, Nunez MG, Sychev ZE, Hegre SA, Sætrom P, Habib N, Drake JM, Schwertfeger KL, et al.#: sc-1428 RRID: AB_2114872,WB (1:1000) Antibody,Rabbit anti-Lck (D88) XP(R),Cell Signaling,Cat. #: 2984 RRID: AB_2136313,WB (1:2000) Antibody,Rabbit anti-LynA (C13F9),Cell Signaling,Cat. #: 2796 RRID: AB_2138391,WB

(10) Evidence for neurogenesis in the medial cortex of the leopard gecko, Eublepharis maculariusScientific reportsJune 25, 2018McDonald RP, Vickaryous MK.

(11) Midostaurin, a Natural Product-Derived Kinase Inhibitor Recently Approved for the Treatment of Hematological MalignanciesPublished as part of the Biochemistry series "Biochemistry to Bedside"BiochemistryFebruary 6, 2018Paul W. Manley, Ellen Weisberg, Martin Sattler, James D. Griffinpermission from Cell Signaling Inc. Reprinted with permission from Zarrinkar et al. Blood 2009;114:2984–2992.

(12) A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase DegraderCell chemical biologyJanuary 18, 2018Huang HT, Dobrovolsky D, Paulk J, Yang G, Weisberg EL, Doctor ZM, Buckley DL, Cho JH, Ko E, Jang J, et al.,Cell Signaling Technology,Cat#3230S; RRID: AB_2128522 Rabbit monoclonal anti-LCK (D88),Cell Signaling Technology,Cat#2984T; RRID: AB_2136313 Rabbit monoclonal anti-LC3A/B (D3U4C),Cell Signaling Technology,Cat#12741T; RRID:

(13) Pro-survival effects by NF-κB, Akt and ERK(1/2) and anti-apoptosis actions by Six1 disrupt apoptotic functions of TRAIL-Dr4/5 pathway in ovarian cancerBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapieDecember 1, 2016Yang J, Li G, Zhang K.

(14) In vitro membrane reconstitution of the T-cell receptor proximal signaling networkNature Structural & Molecular BiologyFebruary 1, 2014Enfu Hui, Ronald D. Valeanti-pY505-Lck (558552, BD PhosFlow, 1:3,000), anti-GAPDH (MAB374, Millipore, 1:50,000), rabbit anti-Lck (2984S, Cell signaling, 1:1,000), rabbit anti-pY416-Src (2101S, Cell signaling, 1:1,000). Validation of each

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Lck (D88) XP ® Rabbit mAb

Lck (D88) XP ® Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Lck (D88) XP ® Rabbit mAb from Cell Signaling Technology

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