Phospho-Chk2 (Thr68) (C13C1) Rabbit mAb 2197S from Cell Signaling Technology

Product Specs
ItemPhospho-Chk2 (Thr68) (C13C1) Rabbit mAb
CompanyCell Signaling Technology
Price $397.00 Inquire
Catalog Number2197S
Quantity100 µl
ApplicationsW, W-S, IP, IHC-P
ReactivityH
TargetChk2 (Thr68) phosphate
ModificationsChk2 (Thr68) phosphate
HostRabbit
NCBI Gene AliasesCDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1
ClonalityMonoclonal
NCBI Full Gene Namecheckpoint kinase 2
Research AreaCell Cycle / Checkpoint Control
CloneC13C1
Molecular Weight62
IsotypeIgG

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) TFEB confers resistance against the chemotherapeutic agent CX-5461Autophagy ReportsDecember 31, 2026Marjorie Rolland, Benoît Marchand, Laure Bessy, Florence McDuff, Marie-Josée Boucher377,293), CATHEPSIN B (Cell Signaling Technology, 31,718), p-CHK2Thr68 (Cell Signaling Technology, 2197), CHK2 (Santa Cruz Biotechnology, 5278), p-DNA-PKcsSer2056 (Cell Signaling Technology, 68,716), DNA-PKcs

(2) Hsp70 is phosphorylated in a conserved response to DNA damage and contributes to cell cycle controlElifeMay 27, 2026Thomas Moss, Alexandra Wooldredge, Koustav Bhakta, Matthew Cronin, Jason E Gestwicki, Shaeri Mukherjeepolyclonal)",Abcam,ab18192,WB (1:1000) Antibody,"Anti-phospho-Chk2 (T68) (rabbit, monoclonal)",Cell Signaling Technology,2197T,WB (1:1000) Antibody,"Anti-Hsp90 (rabbit, polyclonal)",Cell Signaling Technology,4874S,WB (1:1000) Antibody,"Anti-phospho-Chk2

(3) Oxidative DNA lesions destabilize centromeres and drive chromosome instabilitybioRxivMay 1, 2026Lily Thompson, Rim Nassar, Annapaola Angrisani, Owen Ou Ning Hsiu, Yian Yang, Katarzina M Kedziora, Daniela Muoio, Daniele Fachinetti, Wayne Stallaert, Elise FouquerelWB dilution 1:1000), anti-phospho-Chk2 (Thr68)(C13C1) rabbit monoclonal antibody (Cell Signaling Cat#2197, WB dilution 1:1000), anti-Chk2 (1C12) mouse monoclonal antibody (Cell Signaling Cat#3440, WB dilution

(4) The DNA helicase HELQ promotes replication fork reversal in coordination with BRCA2- and FANCD2-mediated repair pathwaysNucleic Acids ResApril 29, 2026Yerkin Dunbayev, Yen-Ju Chen, Lorenzo Sassi, Eun A Lee, Jae Sun Ra, Moonjung Choi, Anirban Mukherjee, Karen M Vasquez, Vincenzo Costanzo, Peter Chi, et al.1:1000), pSer1981 ATM (ab81292, Abcam, 1:5000), CHK2 (2662, Cell Signaling, 1:500), and pThr68 CHK2 (2197, Cell Signaling, 1:1000). DNA fiber assays DNA combing was performed as previously described [28].

(5) Emergence and evolution of chimeric pseudogenes (φgenes) contribute to genetic and functional diversity of the human genomeNucleic Acids ResApril 28, 2026Amruta R Jadhav, Sushmita Sahoo, Yash L Kuber, Krutika Hatwar, Avinash Varanwal, Khushi Tanwar, Shubhankar Palwankar, Gauri Chatrasal, Avinash M Mali, Sharmila A Bapatantibodies (1:1000 dilution in 5% BSA unless otherwise stated): phospho-ATR (CST #2853), phospho-Chk2 (CST #2197), PICT1 (CST #73225), β-tubulin (CST #sc-166729), anti-FLAG (Sigma #F1804, diluted in 3% milk), and

(6) SKA2 promotes gastric cancer progression by regulating glutathione metabolismiScienceApril 17, 2026Peng Zhang, Jianfeng Zhong, Ting Zhou, Depei Jiang, Zijing Wang, Meifang Ye, Lekun Fang, Huizhen Xiong, Honglei ChenAB_2062659 p-ATM,Cell Signaling Technology,Cat# 5883; RRID: AB_10835213 p-chk2,Cell Signaling Technology,Cat# 2197; RRID: AB_2080501 ,, Bacterial and virus strains,Bacterial and virus strains,Bacterial and virus strains ,, DH5α

(7) Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP InhibitionCancer ResApril 2, 2026Joseph L. Sottnik, Madeleine T. Shackleford, Camryn S. Nesiba, Amanda L. Richer, Zoe Fleischmann, Jordan M. Swartz, Carmen E. Rowland, Maggie Musick, Rui Fu, Logan R. Myler, et al.(Cell Signaling Technology #2348; RRID:AB_331212); phospho-CHK2 (Thr68)(C13C1)(Cell Signaling Technology #2197; RRID:AB_2080501); 53BP1 (E7N5D) XP (Cell Signaling Technology #88439; RRID:AB_3095656); phospho-53BP1

(8) GSK3i combinatorial treatments affect CDK4/6 and compensatory pathways in 3D preclinical models of pancreatic neuroendocrine tumorsBiology OpenMarch 15, 2026Edlira Luca, Igor Shapiro, Huguette Debaix, Kathrin Zitzmann, Katharina Wang, Christoph J. Auernhammer, Felix Beuschlein, Svenja Nölting, Constanze HantelSanta Cruz Biotechnology (USA)",1:100 CDK 1/2,"sc-53219, Santa Cruz Biotechnology (USA)",1:100 phospho-Chk2,"2197, Cell Signaling Technology (Danvers, MA, USA)",1:200 phospho-Chk1,"2348, Cell Signaling Technology

(9) PRMT5 is Frequently Upregulated and a Potential Therapeutic Target in MTAP-deficient Malignant Peripheral Nerve Sheath TumorsbioRxivMarch 13, 2026Dingxun Wang, Melissa L. Fishel, Azadeh Samiei, Silpa Gampala, Changdeng Hu, Shaoxiong Chen, GuangJun Zhang(Cell Signaling Technology, cat# 2360, RRID:AB_2080320, 1:1000), anti-phospho-CHK2 (Cell Signaling Technology, cat# 2197, RRID:AB_2080501, 1:1000), anti-CHK2 (Cell Signaling Technology, cat# 6334, RRID:AB_11178526, 1:1000),

(10) Inhibition of NAMPT targets DNA damage response to sensitize alkylating chemotherapy in TP53 mutant mantle cell lymphoma∗Blood AdvancesMarch 10, 2026Na Li, Yicen Liu, Linna Zhang, Saisai Guo, Zhihao Wu, Yan Xu, Ming Yang, Jixia Kong, Yuxuan Che, Kun Shao, et al.2853s), p-ATM (Ser1981; Cell Signaling Technology, 4526s), and p-CHK2 (Thr68; Cell Signaling Technology, 2197s). Glyceraldehyde-3-phosphate dehydrogenase (GAPDH; Cell Signaling Technology, 2118) and α-tubulin (Santa Cruz Biotechnology

(11) CF10 Displays Improved Synergy with Oxaliplatin in TP53-Null and Wild-Type CRC Cells from Increased Top1cc and Replication StressCancers (Basel)March 9, 2026Taylor M. Young, Rida Moumouni, Akanksha Behl, Upasana Das, William H. GmeinerMA, USA, Cat. No. 2348, RRID: AB_331212), Phospho-Chk2 (Thr68) (Cell Signaling Technology Cat. No. 2197, RRID: AB_2080501), Chk1 (Cell Signaling Technology Cat# 37010, RRID: AB_3662851), Chk2 (Cell Signaling Technology

(12) Targeting de novo pyrimidine synthesis confers vulnerability to copper-mediated ATR inactivation in PARP inhibitor-resistant ovarian cancerNature CommunicationsFebruary 25, 2026Yabing Nan, Kunyu Wang, Menghan Hu, Qingyu Luo, Xiaowei Wu, Xiao Yu, Xuantong Zhou, Li Chen, Bin Li, Zhumei Cui, et al.Cell Signaling Technology), anti-ATM (1:1000; 2873, Cell Signaling Technology), anti-p-CHK2 (T68) (1:1000; 2197, Cell Signaling Technology), anti-CHK2 (1:1000; 6334, Cell Signaling Technology), anti-γ-H2AX (1:5000;

(13) Differentiation-dependent proximity proteomics identifies novel host factors linked to HPV16 E2 functionmBioFebruary 11, 2026Claire D. James, Aya Youssef, Apurva T. Prabhakar, Jenny D. Roe, Elinor Lu, Austin Witt, Sarita Giri, Molly L. Bristol, Phoebe Bridy, Xu Wang, et al.(ThermoFisher MA1-46069), CHK1 (Cell Signaling 2360), CHK2 (Cell Signaling 2622), phospho-CHK1 (Cell Signaling 2197), phospho-CHK2 (Cell Signaling 2197), HPV16 E2 (clone B9) (57) and γH2AX (phospho-S139; Cell Signaling

(14) Targeting miR-4653-3p/SLC25A51/SIRT3 axis to induce synthetic lethality in ARID1A-deficient colorectal cancer via blockade of DNA repairJournal of Translational MedicineFebruary 4, 2026Xin Lin, Changjie Wu, Danzhu Wu, Wenjie Qin, Yingyi Zeng, Yixian Song, Li Xiang, Joong Sup Shim, Side Liu, Aimin Li(Cell Signaling Technology, #2348T, 1:1000 dilution), Phospho-Chk2 (Thr68) (Cell Signaling Technology, #2197T, 1:1000 dilution), ATM (Abcam, #ab199726, 1:2000 dilution), ATR (Proteintech, #19787-1-AP, 1:1000 dilution),

(15) Circular RNA circATM binds PARP1 to suppress Wnt/β-catenin signaling and induce cell cycle arrest in gastric cancer cellsJournal of Advanced ResearchFebruary 1, 2026Xiaohui Zhu, Xiaojing Zhang, Ying Qin, Yang Chen, Xianling Feng, Shiqi Deng, Fan Hu, Yuan Yuan, Xiaonuan Luo, Kaining Du, et al.(Cell Signaling Technology Cat# 6334, RRID:AB_11178526), phospho-Chk2 (Cell Signaling Technology Cat# 2197, RRID:AB_2080501), GAPDH (Cell Signaling Technology Cat# 5174, RRID:AB_10622025), cyclin D1, c-Jun,

(16) APOBEC3B enhances the efficacy of PARP inhibitors in elimination of ovarian cancer stem cellScientific ReportsJanuary 14, 2026Maria Rivera, Lucy Liu, Sabina Enlund, Chae-Eun Lim, Haoran Zhang, Kaifu Yang, Roman Sasik, Leslie A. Crews, Kathleen M. Fisch, Ramez N. Eskander, et al.(Cell Signaling, Cat #2853); pATM (S1981) (Cell Signaling, Cat #13,050); pChk2 (Thr68) (Cell Signaling, Cat #2197); phosphor-p53 (S15) (Cell Signaling, Cat #9286); pBRCA1 (S1524) (Cell Signaling, Cat #9009); beta-actin

(17) Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP InhibitionCancer ResearchJanuary 9, 2026Joseph L. Sottnik, Madeleine T. Shackleford, Camryn S. Nesiba, Amanda L. Richer, Zoe Fleischmann, Jordan M. Swartz, Carmen E. Rowland, Maggie Musick, Rui Fu, Logan R. Myler, et al.(Cell Signaling Technology #2348; RRID:AB_331212); phospho-CHK2 (Thr68)(C13C1)(Cell Signaling Technology #2197; RRID:AB_2080501); 53BP1 (E7N5D) XP (Cell Signaling Technology #88439; RRID:AB_3095656); phospho-53BP1

(18) 6-Gingerol alleviates high glucose-induced inflammation and cytotoxicity in THP-1 cells by inhibiting TLR4 signalingScientific ReportsJanuary 7, 2026Dong Young Kang, Won-Jae Chi, Jaehoon Cho, Kyoung-Jin Jang(#4511), p38 (#8690), IL-1β (#12703), p27 (#3686), p53 (#9282), p-BRCA1 (#9009), p-CHK1 (#2348), p-CHK2 (#2197), p-ATM (#5883), p-ATR (#2853), p-Histone (#9718), p-P53 (#9286), pJAK2 (#3776), JAK2 (#3230), pMDM2

(19) DNA damaging agents boost the transcription of endothelin A receptor in high-grade serous ovarian cancerJournal of Experimental & Clinical Cancer ResearchDecember 6, 2025Celia Roman, Rosanna Sestito, Valentina Caprara, Andrea Sacconi, Giovanni Blandino, Anna Bagnato, Piera Toccianti-CHK1 (2G1D5) (1:1000, cat. no. 2360, Cell Signalling); anti-pCHK2 (T68) (C13C1) (1:1000, cat. no. 2197, Cell Signalling); anti-CHK2 (1:1000, cat. no. 2662, Cell Signalling); anti-pSTAT3 (Y705) (D3A7) (1:1000;

(20) Differential effects of mercury compounds on mutagenicity, genotoxicity and repair of UV-DNA damageToxicologyDecember 1, 2025Anna Cyran, Giorgiana Madalina Ursu, Casey Krawic, Anatoly Zhitkovichphospho-S15-p53 (9284), phospho-S317-CHK1 (12302), phospho-S345-CHK1 (2348), CHK1 (2360), phospho-T68-CHK2 (2197), CHK2 (3440), XPC (12701), XPF (13465), HMGN1 (5692), lamin B1 (12586), fibrillarin (2639) and L7A

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Phospho-Chk2 (Thr68) (C13C1) Rabbit mAb

Phospho-Chk2 (Thr68) (C13C1) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

Citations (343)

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Phospho-Chk2 (Thr68) (C13C1) Rabbit mAb from Cell Signaling Technology

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