Akt2 (D6G4) Rabbit mAb 3063S from Cell Signaling Technology

Product Specs
ItemAkt2 (D6G4) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number3063S
Quantity100 µl
ApplicationsW, W-S, IP
ReactivityH, M, R, Mk
TargetAkt2
HostRabbit
NCBI Gene AliasesHIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA
ClonalityMonoclonal
NCBI Full Gene NameAKT serine/threonine kinase 2
Research AreaPI3K / Akt Signaling
IsotypeIgG
CloneD6G4
Molecular Weight60

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Vav1 Sustains the Expression of Insulin, PDX1 and miR-375 During Differentiation of hiPSCs to β Cells: A Potential Target to Improve the In Vitro Generation of Insulin-Producing CellsTissue Engineering and Regenerative MedicineFebruary 1, 2026Marina Pierantoni, Valentina Zamarian, Federica Brugnoli, Silvia Grassilli, Laura Monaco, Marcello Dell’Aira, Valeria Sordi, Valeria BertagnoloProteintech, Manchester, UK), PDX1 (AF2419 R&D Systems, Minneapolis, MN, USA), pSer474-Akt2 (8599S) and Akt2 (3063 s) from Cell Signaling Technology, pSer473-Akt1 (05-736 Merck Millipore, Milan, Italy), Akt1 (sc‐377457)

(2) SerpinA3k Deficiency Ameliorates Experimental type 2 DiabetesCell Mol Life SciDecember 2, 2025Isaac González-Soria, Esmeralda Palacios-Brito, Dulce Gómez-Trujillo, Karla Barragán-Jiménez, Axel D. Soto-Valadez, Miguel Angel Martínez-Rojas, Daniel Oliva-García, Jorge Aranda, Rosalba Pérez-Villalva, Lorena López-Griego, et al.USA), pAKT2 Ser474 (1,2,000; Cat. No, 8599 S, Cell Signaling, MA, USA), totalAKT2 (1:2,000; Cat. No. 3063 S, Cell Signaling, MA, USA) and interleukin 6 (1:1000, Cat. No. SABS700632, Sigma, USA). For sequential

(3) Androgen deprivation–mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusionJournal of Clinical InvestigationDecember 1, 2025Fen Ma, Sen Chen, Luigi Cecchi, Betul Ersoy-Fazlioglu, Joshua W. Russo, Seiji Arai, Seifeldin Awad, Carla Calagua, Fang Xie, Larysa Poluben, et al.2938, 1:1,000), AKT1 pS473 (Cell Signaling Technology, 9018, 1:1,000), AKT2 (Cell Signaling Technology, 3063, 1:1,000), AKT2 pS474 (Cell Signaling Technology, 8599, 1:1,000), PTEN (Cell Signaling Technology, 9559,

(4) Macrophage CCL7 promotes resistance to immunotherapy for colorectal cancer by regulating the infiltration of macrophages and CD8 + T cellsJournal for ImmunoTherapy of CancerNovember 24, 2025Yijiao Chen, Xudong Liu, Jiongming Chen, Liwen Kuang, Nan Zhang, Danyang Li, Dan Zhao, Dongmei Xue, Juan Lei, Jiangang Zhang, et al.CST), p-AKT1 (1:1,000; Cat No. 2938, CST), AKT1 (1:1,000; Cat No. 9018, CST), AKT2 (1:1,000; Cat No. 3063, CST), Stat1 (1:1,000; Cat No. 9172, CST), and β-actin (1:1,000; Cat No. A1978, Sigma-Aldrich). Statistical

(5) The inhibitory SAPS3 – AMPK interaction detected in HEK293 cells is not detectable in muscle or liver from humans or miceFEBS LettersNovember 17, 2025Jesper B. Birk, Maria A. Møller, Jørgen F.P. Wojtaszewski, Rasmus Kjøbstedphospho‐p38‐T180/Y182 (no.: 9211), phospho‐Akt‐S473 (no.: 9271), phospho‐p70S6K‐T389 (no.: 9205), Akt2 (no.: 3063), p70S6K (no.: 9202), p38 (no.: 9212), and β‐actin (no.: 4967) were from Cell Signaling Technology,

(6) Dual Role of Diallyl Disulfide (DADS) on Invasive Potential and β-Catenin Dynamics in HER2-Positive Breast Cancer CellsCancers (Basel)November 5, 2025Marcello Dell’Aira, Silvia Grassilli, Marina Pierantoni, Valeria Bertagnolo, Federica Brugnoli(sc-7963) from Santa Cruz Biotechnology (Heidelberg, Germany); Akt (AF2055), p-Akt (#3787S), Akt2 (#3063), p-Akt2 (Ser474, #8599), p-GSK-3β (Ser9, #5558) and GSK-3β (#9315) from Cell Signaling Technology (Danvers,

(7) Phosphorylation of plectin by Akt3 promotes triple-negative breast cancer cell invasive migrationiScienceOctober 17, 2025Shixue Zheng, Chloe Chan, John M. Asara, Liang Zhang, Gerhard Wiche, Y. Rebecca Chin(2997S), anti-PRAS40 (2691S), anti-phospho-GSK3β (9336S), anti-GSK3β (9315), anti-Akt1 (2938S), anti-Akt2 (3063S), anti-Akt3 (8018S), and anti-actin (3700S) were purchased from Cell Signaling Technology. Anti-plectin

(8) Akt isoform specificity drives intrinsic immune regulation during HSV-1 infectionProc Natl Acad Sci U S AJuly 8, 2025Rahul K. Suryawanshi, Chandrashekhar D. Patil, Hemant Borase, Deepak Shukla(9271S) 1:500, FoxO1 (2880) 1:1,000, Akt1 (2938) 1:500, Phospho-Akt1 (Ser473) (9018) 1:500, Akt2 (D6G4) (3063) 1:1,000, and Phospho-Akt2 (Ser474) (8599) 1:500, all purchased from Cell Signaling Technology (Danvers,

(9) Deficiency in N-cadherin-Akt3 signaling impairs the blood-brain barrierCell ReportsJune 24, 2025Quinn Lee, Wan Ching Chan, Shuangping Zhao, Harry M. Hailemeskel, Riya Thomas, Mohsin Zafar, Fozia Mir, Peter T. Toth, Kamran Avanaki, Leon M. Tai, et al.Invitrogen), SV2A (#ab32942, Abcam), GAD67 (#ab26116, Abcam), Akt1 (#2938, Cell Signaling Technology), Akt2 (#3063, Cell Signaling Technology), Akt3 (#8018, Cell Signaling Technology), and β-actin (#sc-47778, Santa Cruz

(10) Loss of neurofibromin induces inflammatory macrophage phenotypic switch and retinal neovascularization via GLUT1 activationCell ReportsMay 27, 2025Yusra Zaidi, Rebekah Tritz, Nida Zaidi, Faisal Nabi, Syed Adeel H. Zaidi, Abdelhakim Morsy, Valerie Harris, Rilee Racine, Farlyn Z. Hudson, Zsuzsanna Bordan, et al.2938, 1:1000), Rabbit phospho-Akt-2 (Ser474) (D3H2) (CST; 8599, 1:1000), Rabbit Akt-2 (D6G4) (CST; 3063, 1:1000), Rat F4/80 (Bio-Rad, MCA497R). Membranes were incubated with HRP-conjugated secondary antibodies

(11) CDO1 phosphorylation is required for IL-6-induced tumor cell proliferation through governing cysteine availabilityCell Commun SignalApril 23, 2025Xin Li, Zhe Zhao, Hongping Ye, Dan Li, Xiaoke Huang, Jong-Ho Lee, Rui Liuretards IL-6-elicited growth for OSCC. Materials and methods Materials Antibodies recognizing AKT2 (#3063), AKT3 (#14,982), AKT1 pS473 (#9018), AKT1 pT308 (#13,038), phosphothreonine (#9386) and STAT3 pY705

(12) Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signalingCell ReportsApril 22, 2025Allison Wing, Elise Jeffery, Christopher D. Church, Jennifer Goodell, Rocío del M. Saavedra-Peña, Moumita Saha, Brandon Holtrup, Maud Voisin, N. Sima Alavi, Mariana Floody, et al.AB_2338393" "GP38 PE, 1:500",Biolegend,"337003, RRID:AB_1595554" "Rabbit Akt2, 1:1000",Cell Signaling,"3063, RRID:AB_2225186" "Rabbit phospho-Akt2, 1:500",Cell Signaling,"8599, RRID:AB_2630347" "Anti-rabbit

(13) Revisiting Insulin-Stimulated Hydrogen Peroxide Dynamics Reveals a Cytosolic Reductive Shift in Skeletal MuscleRedox BiologyMarch 25, 2025Carlos Henríquez-Olguín, Samantha Gallero, Anita Reddy, Kaspar W. Persson, Farina L. Schlabs, Christian T. Voldstedlund, Gintare Valentinaviciute, Roberto Meneses-Valdés, Casper M. Sigvardsen, Bente Kiens, et al.Signaling Technology,"1:1000, 3 % BSA",9275 Akt2,Cell Signaling Technology,"1:1000, 3 % skim milk",3063 TBC1D4 Thr642,Cell Signaling Technology,"1:1000, 3 % skim milk",4288 PRDX3,Abfrontier,"1:1000, 3 %

(14) AKT activation triggers Rab14-mediated ADAM10 translocation to the cell surface in human aortic endothelial cellsSci RepMarch 3, 2025Chung Hee Baek, Hyosang Kim, Soo Young Moon, Eun Kyoung Lee, Won Seok Yangp-AKT1Ser473 (AP0140), and p-AKT2Ser474 (AP0005) were from ABclonal, Inc. (Woburn, MA, USA). AKT2 antibody (#3063) was from Cell Signaling Technology, Inc. (Danvers, MA, USA). p-AKT3Ser472 (PAB8141) antibody was from

(15) S100A8/A9 innate immune signaling as a distinct mechanism driving progression of smoking-related breast cancersOncogeneJanuary 25, 2025Samson Mugisha, Shahnawaz A. Baba, Shreyas Labhsetwar, Devam Dave, Aran Zakeri, Richard Klemke, Jay S. Desgrosellierfor immunoblotting at the following dilutions: 1:1000 S100A9 (Cat# 72590), p-AKT (Cat# 8599), total Akt (Cat# 3063), p-STAT3 (Cat# 9131), total STAT3 (Cat# 9139), p-ERK(1/2) (Cat# 4370), total ERK(1/2) (Cat# 4696),

(16) Pleiotropic tumor suppressive functions of PTEN missense mutations during gliomagenesisiScienceDecember 20, 2024Hyun Jung Jun, Joao A. Paulo, Victoria A. Appleman, Tomer M. Yaron-Barir, Jared L. Johnson, Alan T. Yeo, Vaughn A. Rogers, Shan Kuang, Hemant Varma, Steven P. Gygi, et al.,Cell Signaling Technology,2938 anti-AKT2Ser-474,Cell Signaling Technology,8599 anti-AKT2,Cell Signaling Technology,3063 anti-PRAS40-Thr-246,Cell Signaling Technology,2997 anti-PRAS40,Cell Signaling Technology,2691 anti-PTEN,Invitrogen,MA5-12278 anti-GFPA,Dako,Z0334 anti-NEU,Thermo Fisher

(17) YAP promotes global mRNA translation to fuel oncogenic growth despite starvationExperimental & molecular medicineOctober 1, 2024Hwang D, Baek S, Chang J, Seol T, Ku B, Ha H, Lee H, Cho S, Roh TY, Kim YK, et al.#9202), phospho-AKT (Cell Signaling Technology, #4060 and #4056), AKT2 (Cell Signaling Technology, #3063), eIF4E (Santa Cruz Biotechnology, sc-9976), PABP-C1 (Abcam, ab21060), phospho-paxillin (Cell Signaling Technology

(18) Ketogenic diet but not free-sugar restriction alters glucose tolerance, lipid metabolism, peripheral tissue phenotype, and gut microbiome: RCTCell Reports MedicineAugust 20, 2024Aaron Hengist, Russell G. Davies, Jean-Philippe Walhin, Jariya Buniam, Lucy H. Merrell, Lucy Rogers, Louise Bradshaw, Alfonso Moreno-Cabañas, Peter J. Rogers, Jeff M. Brunstrom, et al.RESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies ,, INSR,Cell Signaling,3025 IRS1,Merk,2387826 Akt,Cell Signaling,3063 AS160,Cell Signaling,2670 AMPK,Cell Signaling,2532 GLUT4,Custom made antibody,N/A TGR5,ABCAM,Ab72608 PLIN,Cell Signaling

(19) Down-Regulation of AKT Proteins Slows the Growth of Mutant-KRAS Pancreatic TumorsCellsJune 19, 2024Chuankai Chen, Ya-Ping Jiang, Inchul You, Nathanael S. Gray, Richard Z. Lin(Cell Signaling, #2215), p-PRAS40 (Cell Signaling, #2997), AKT1 (Cell Signaling, #2967), AKT2 (Cell Signaling, #3063), AKT3 (Cell Signaling, #3788), ACTIN (Cell Signaling, #3700), PRAS40 (Cell Signaling, #2961), p-GSK3beta

(20) Effects of Garlic on Breast Tumor Cells with a Triple Negative Phenotype: Peculiar Subtype-Dependent Down-Modulation of Akt SignalingCellsMay 11, 2024Federica Brugnoli, Marcello Dell’Aira, Paola Tedeschi, Silvia Grassilli, Marina Pierantoni, Rebecca Foschi, Valeria Bertagnolo(sc-373717), and β-Catenin (sc-7963) from Santa Cruz Biotechnology (Santa Cruz, CA, USA); against Akt2 (#3063), p-Akt2 (Ser474, #8599), p-GSK-3β (Ser9, #5558), GSK-3β (#9315), p-p70 S6 Kinase (Thr389, #9205), and

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(1)

7/11/2023Akt2 from Cell Signaling Technology Works for Human and Mouse Samples Soonyoung ParkCell lines from syngeneic mouse models were over-expressed Akt2. The immunoblotting procedure is described below. Lyse cells by adding RIPA (with Proteinase and Phosphatase inhibitors) buffer. Heat ... Read Review
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8/1/2022Effect of AKT2 Expression by Chemoattractant Somasundaram RaghavanAKt2 otherwise called RAC-beta serine/threonine-protein kinase, it is an enzyme that encodes in humans AKT2 gene. It involved in metabolite storage and plays a important role insulin signal ... Read Review
(1)

6/3/2014Akt 2 Detection Raul PeñaEpithelial-mesenchymal transition is a cellular process in which the repressor SNA1 transcription factor regulates negatively E-Cadh promoter. Findings of our lab demonstrate the mechanism is which ... Read Review

Akt2 (D6G4) Rabbit mAb

Akt2 (D6G4) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Akt2 (D6G4) Rabbit mAb from Cell Signaling Technology

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