The Rabbit Polyclonal to Human GRM5 / MGLUR5 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to GRM5, and mGluR5. This antibody recognizes Human, Mouse, Rat, Bovine, Canine, Chicken/Bird, Hamster, Horse, Non-Human Primate, Porcine, Rabbit, and Other Mammalian antigen. The Rabbit Polyclonal to Human GRM5 / MGLUR5 Antibody has been shown to work in the following applications: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
Group I of the Metabotropic Glutamate Receptors includes GRM1 and GRM5, receptors that have been shown to activate phospholipase C. Alternative splice variants of GRM5 have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain