Phospho-c-Kit (Tyr703) (D12E12) Rabbit mAb 3073S from Cell Signaling Technology

Product Specs
ItemPhospho-c-Kit (Tyr703) (D12E12) Rabbit mAb
CompanyCell Signaling Technology
Price $462.00 Inquire
Catalog Number3073S
Quantity100 µl
ApplicationsW, IP
ReactivityH
TargetKit (Tyr703) phosphate
ModificationsKit (Tyr703) phosphate
HostRabbit
NCBI Gene AliasesC-Kit, CD117, MASTC, PBT, SCFR
ClonalityMonoclonal
NCBI Full Gene NameKIT proto-oncogene, receptor tyrosine kinase
Research AreaRTK
IsotypeIgG
CloneD12E12
Molecular Weight145

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Targeting yes-associated protein to overcome imatinib resistance in gastrointestinal stromal tumor drug-tolerant persister cellsGastric CancerNovember 1, 2025Takashi Yokouchi, Tsuyoshi Takahashi, Toshirou Nishida, Koji Tanaka, Yukinori Kurokawa, Kazuyoshi Yamamoto, Takuro Saito, Takaomi Hagi, Kota Momose, Kotaro Yamashita, et al.as described previously [19]. Antibodies used included c-KIT (D13A2, #3074), phospho-c-KIT (Tyr703, #3073), YAP (D8H1X, #14074), and phospho-YAP (Ser127, #13008). The secondary antibody, horse-radish peroxidase-conjugated

(2) M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in CancerMolecular Cancer TherapeuticsJuly 2, 2025Christina Esdar, Nina Linde, Andreas Blum, Hanno Schieferstein, Christine Drechsler, Eva Sherbetjian, Carl Petersson, Edith Ross, Birgitta Leuthner, Ulrich Grädler, et al.microsphere beads for capturing and a rabbit monoclonal P-Y703-KIT (Cell Signaling Technology, cat #3073, RRID: AB_1147635) or a rabbit monoclonal KIT (Cell Signaling Technology, cat #3074, RRID: AB_1147633)

(3) A Canine c-kit Novel Mutation Isolated from a Gastrointestinal Stromal Tumor (GIST) Retains the Ability to Form Dimers but Lacks AutophosphorylationAnimals (Basel)May 16, 2025Kei Shimakawa, So Doge, Masaki Michishita, Eri Tanabe, Tsuyoshi Tajima, Masato Kobayashi, Makoto Bonkobara, Masami Watanabe, Kazuhiko Ochiai, Yoshikazu Tanakafollowing antibodies: anti-KIT (1:2000; 18696-1-AP, Proteintech, Tokyo, Japan), anti-phospho-KIT (1:1000; 3073, Cell Signaling Technology, CST, Danvers, MA, USA), anti-Akt (1:1000; 4691, CST), rabbit polyclonal

(4) M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in CancerMol Cancer TherFebruary 28, 2025Christina Esdar, Nina Linde, Andreas Blum, Hanno Schieferstein, Christine Drechsler, Eva Sherbetjian, Carl Petersson, Edith Ross, Birgitta Leuthner, Ulrich Grädler, et al.microsphere beads for capturing and a rabbit monoclonal P-Y703-KIT (Cell Signaling Technology, cat #3073, RRID: AB_1147635) or a rabbit monoclonal KIT (Cell Signaling Technology, cat #3074, RRID: AB_1147633)

(5) Exploring the Reactivity of Rigid 1-Azadienes Derived from Methylene γ-Lactams. Applications to the Stereoselective Synthesis of Spiro-γ-LactamsThe Journal of Organic ChemistryJuly 5, 2024Adrián López-Francés, Zuriñe Serna-Burgos, Xabier del Corte, Jesús M. de los Santos, Abel de Cózar, Javier Vicario116.8 (2 × CHAr), 99.8 (=CH), 49.8 (CH2), 21.0 (CH3), 20.8 (CH3) ppm. FTIR (neat) nmax: 3325 (NHst), 3073 (=CHst), 1671 (C=Ost), 1644 (C=Cst) cm–1. HRMS (ESI-TOF) m/z calcd for C18H19N2O [M + H]+, 279.1497;

(6) Hypoxia-inducible factor 1α inhibitor induces cell death via suppression of BCR-ABL1 and Met expression in BCR-ABL1 tyrosine kinase inhibitor sensitive and resistant chronic myeloid leukemia cellsBMB ReportsFebruary 28, 2023Masanobu Tsubaki, Tomoya Takeda, Takuya Matsuda, Akihiro Kimura, Remi Tanaka, Sakiko Nagayoshi, Tadafumi Hoshida, Kazufumi Tanabe, Shozo Nishida(#2862), anti-phospho-MET antibody (#3126), anti-MET antibody (#4560), anti-phospho-JNK antibody (#3073), anti-JNK antibody (#9252), anti-phospho-Akt antibody (#9271), anti-Akt antibody (#9272), anti-phospho-ERK1/2

(7) Hypoxia-inducible factor 1α inhibitor induces cell death via suppression of BCR-ABL1 and Met expression in BCR-ABL1 tyrosine kinase inhibitor sensitive and resistant chronic myeloid leukemia cellsBMB RepJanuary 31, 2023Masanobu Tsubaki, Tomoya Takeda, Takuya Matsuda, Akihiro Kimura, Remi Tanaka, Sakiko Nagayoshi, Tadafumi Hoshida, Kazufumi Tanabe, Shozo Nishida(#2862), anti-phospho-MET antibody (#3126), anti-MET antibody (#4560), anti-phospho-JNK antibody (#3073), anti-JNK antibody (#9252), anti-phospho-Akt antibody (#9271), anti-Akt antibody (#9272), anti-phospho-ERK1/2

(8) Chinese Pedigree with Hereditary Gastrointestinal Stromal Tumors: A Case Report and Literature ReviewInternational Journal of Molecular SciencesJanuary 3, 2023Qichao Ge, Yang Liu, Fan Yang, Guangwei Sun, Jintao Guo, Siyu Sun(cat#4904, CST), Phospho-Stat3 (cat#9145, CST), c-Kit (cat#3074, CST), Phospho-c-Kit (Tyr703) (cat#3073, CST), Phospho-c-Kit (Tyr719) (cat#3391, CST), Erk1/2 (cat#4695, CST), and Phospho-Erk (Thr202/Tyr204)

(9) Identification of Thiazolo[5,4-b]pyridine Derivatives as c-KIT Inhibitors for Overcoming Imatinib ResistanceCancersDecember 26, 2022Nam Y, Kim C, Han J, Ryu S, Cho H, Song C, Kim ND, Kim N, Sim T.NC membrane. The membranes were blocked using 5% skim milk in TBS-T buffer. The p-c-KIT (Tyr703, # 3073), p-AKT (Ser473, # 9271), p-ERK (Thr202/Tyr204, # 8544), ERK (# 4695), p-PLCγ (Tyr783, # 14008), p-STAT3

(10) Preclinical Evaluation of the Multiple Tyrosine Kinases Inhibitor Anlotinib in Leukemia Stem CellsPharmaceuticals (Basel, Switzerland)October 25, 2022Jiang Y, Liu L, Jiang Y, Li Z, Feng L, Zhuang X, Lin Z, Chen Q, Chen G, He J, et al.anti-Phospho-Stat5 (4322S), anti-Bcl-2 (4223S), anti-Bcl-xL (2764S), anti-Bax (5023S), anti-Phospho-c-kit (3073S), and anti-GAPDH (D16H11) from Cell Signaling Technology (Danvers, MA, USA). After incubation with horseradish

(11) Evaluation of two semi-supervised learning methods and their combination for automatic classification of bone marrow cellsScientific ReportsOctober 6, 2022Iori Nakamura, Haruhi Ida, Mayu Yabuta, Wataru Kashiwa, Maho Tsukamoto, Shigeki Sato, Syuichi Ota, Naoki Kobayashi, Hiromi Masauzi, Kazunori Okada, et al.AL,Accuracy_CST,DATA_Count_CST,Accuracy_AL,DATA_Count_AL 1,0.83500,425,0.82250,425,0.80875,425 2,0.85000,1694,0.86000,1603,0.81375,828 3,0.86850,3298,0.85500,2719,0.83125,876 4,0.90125,4881,0.87250,3985,0.87375,1150 5,0.91000,6236,0.88625,5487,0.87750,1227 6,0.93125,7901,0.89125,7187,0.90000,1355 7,0.92875,8783,0.86875,8852,0.88000,1597 8,0.93750,"10,804",0.90125,"10,082",0.90750,1701 9,0.93625,"11,981",0.89375,"11,572",0.91875,1814 10,0.94000,"13,624",0.89750,"13,332",0.91375,1909 11,0.92875,"14,907",0.88750,"15,079",0.91750,1963 12,0.93250,"16,966",0.92250,"16,619",0.92125,2172 13,0.94125,"19,558",0.89500,"18,227",0.91125,2250 14,0.94750,"21,903",0.90875,"19,889",0.92000,2420 15,0.95375,"23,774",0.89375,"21,470",0.93000,2593 16,0.96000,"26,231",0.91375,"23,284",0.92250,2711 17,0.95875,"31,603",0.91750,"25,163",0.92000,2791 18,0.95750,"33,787",0.92000,"26,997",0.90875,2843 19,0.95625,"36,585",0.91500,"28,886",0.91875,2974 20,0.97500,"38,465",0.92625,"30,930",0.94000,3073 21,0.96625,"40,778",0.91750,"32,493",0.94125,3178 22,0.96875,"43,232",0.93750,"34,766",0.94125,3304 23,0.96125,"45,112",0.93000,"36,761",0.93250,3395 24,0.97250,"46,006",0.93750,"38,051",0.93000,3574 25,0.97625,"47,843",0.94375,"40,518",0.93500,3682 Added

(12) THZ1 targeting CDK7 suppresses c-KIT transcriptional activity in gastrointestinal stromal tumoursCell communication and signaling : CCSSeptember 8, 2022Sun J, Zhang Q, Sun X, Xue A, Gao X, Shen K.cyclin D1 (#55506), CDK4 (#12790), γ(p-)H2AX (#9718), cleaved PARP (#5625), c-KIT (#3074), phospho-c-KIT (#3073), ERK1/2 (#4695), phospho-ERK1/2 (#4370), AKT (#9272), phospho-AKT (#4060), FLAG (#14793) and Alexa

(13) Nintedanib overcomes drug resistance from upregulation of FGFR signalling and imatinib‐induced KIT mutations in gastrointestinal stromal tumoursMolecular OncologyApril 1, 2022Juan Liu et al.purchased from Cell Signaling Technology (Danvers, MA, USA): Phospho‐KIT (Tyr703; D12E12) rabbit mAb (no. 3073), Phospho‐KIT (Tyr719) antibody (no. 3391), Phospho‐anti‐KIT (pY823) rabbit mAb (no. 77522), KIT (Ab81)

(14) GCN2 kinase activation by ATP-competitive kinase inhibitorsNature chemical biologyFebruary 1, 2022Tang CP, Clark O, Ferrarone JR, Campos C, Lalani AS, Chodera JD, Intlekofer AM, Elemento O, Mellinghoff IK.(47213/1000x), xCT (12691S/1000x), ASCT2 (8057S/1000x), vinculin (13901S/5000x), Parp-CL (5625S/1000x), P-cKIT (3073S/1000x), cKIT (3074S/2500x) were purchased from Cell signaling. The antibody to GADD34/PPP1R15A (10449–1-AP/1000x)

(15) Dihydromyricetin ameliorates osteogenic differentiation of human aortic valve interstitial cells by targeting c-KIT/interleukin-6 signaling pathwayFrontiers in pharmacologyJanuary 1, 2022Zhang S, Fan L, Wang Y, Xu J, Shen Q, Xie J, Zeng Z, Zhou T.Cell Signaling Technology), GAPDH (1:1,000, 60004-1-Ig, Proteintech), and phospho-c-Kit (Tyr703, 1:1,000, #3073, Cell Signaling Technology). Phospho-c-Kit (Tyr823, 1:1,000, #77522, Cell Signaling Technology), Phospho-c-Kit

(16) Plocabulin, a novel tubulin inhibitor, has potent antitumor activity in patient-derived xenograft models of gastrointestinal stromal tumorsTranslational oncologyNovember 1, 2020Wang Y, Wozniak A, Wellens J, Gebreyohannes YK, Guillén MJ, Avilés PM, Debiec-Rychter M, Sciot R, Schöffski P.phospho-4E-BP1 Ser65, ribosomal protein S6, phospho-S6 Ser240/244 and α-tubulin (catalogue numbers: 3391, 3073, 7292, 7291, 9102, 4370, 9644, 9456, 2217, 5364 and 2144, respectively; all from Cell Signaling Technology).

(17) Stem Cell Factor-Inducible MITF-M Expression in Therapeutics for Acquired Skin HyperpigmentationTheranosticsJanuary 1, 2020Yun CY, Roh E, Kim SH, Han J, Lee J, Jung DE, Kim GH, Jung SH, Cho WJ, Han SB, et al.(Cell Signaling, 3074), p-KIT at Tyr-568 and Tyr-570 (Santa Cruz, sc-18076), p-KIT at Tyr-703 (Cell Signaling, 3073), p-KIT at Tyr-721 (Bioss, bs-3242R), GAPDH (Santa Cruz, sc-25778) or histone H1 (Santa Cruz, sc-8030).

(18) Targeting the WEE1 kinase strengthens the antitumor activity of imatinib via promoting KIT autophagic degradation in gastrointestinal stromal tumorsGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer AssociationJanuary 1, 2020Liu W, Zeng X, Yin Y, Li C, Yang W, Wan W, Shi L, Wang G, Tao K, Zhang P.therapy. Antibodies to WEE1 (13084), CDK1 (77055), phosphoCDK1T14 (4539), KIT (3074), phospho-KITT703 (3073), AKT (4685), phospho-AKTS473 (4060), mTOR (2893), phospho-mTORS2448 (5536), ERK1/2 (4695), phospho-ERK1/2 (4370),

(19) Comparison of effects of midostaurin, crenolanib, quizartinib, gilteritinib, sorafenib and BLU‐285 on oncogenic mutants of KIT, CBL and FLT3 in haematological malignanciesBritish Journal of HaematologyNovember 1, 2019Ellen Weisberg et al.Cell Signaling Technology were phospho-KIT (Tyr719) (rabbit Ab, #3391), phospho-KIT (Tyr703) (rabbit Ab, #3073), KIT (D13A2) XP (rabbit mAb, #3074), and phospho-FLT3 (Tyr591) (54H1) (mouse mAb, #3466); each was

(20) Nuclear KIT induces a NFKBIB-RELA-KIT autoregulatory loop in imatinib-resistant gastrointestinal stromal tumorsOncogeneSeptember 1, 2019Hsueh YS, Chang HH, Shan YS, Sun HS, Fletcher JA, Li CF, Chen LT.pAb,A4502,,,1:500 LMNB1,SCBT,Goat pAb,SC-6216,,,1:100 p-KIT (clinical sample and mouse),CST,Rabbit pAb,3073 S,,,1:1000 NFKBIB (clinical sample and mouse),Abcam,Rabbit pAb,ab109509,,,1:1000 RELA (clinical sample

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Phospho-c-Kit (Tyr703) (D12E12) Rabbit mAb

Phospho-c-Kit (Tyr703) (D12E12) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Phospho-c-Kit (Tyr703) (D12E12) Rabbit mAb from Cell Signaling Technology

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