c-Kit (D13A2) XP ® Rabbit mAb 3074S from Cell Signaling Technology

Product Specs
Itemc-Kit (D13A2) XP ® Rabbit mAb
CompanyCell Signaling Technology
Price $371.00 Inquire
Catalog Number3074S
ClonalityMonoclonal
NCBI Full Gene NameKIT proto-oncogene, receptor tyrosine kinase
ApplicationsWB, ICC, IF, IP
ReactivityHu, Ms
ModificationsKit (Tyr703) phosphate
Research AreaRTK
CloneD13A2
Molecular Weight120 and 145
NCBI Gene AliasesC-Kit, CD117, MASTC, PBT, SCFR
HostRabbit
Targetc-Kit
Quantity100 µl

Questions and Answers

Can this antibody be used for studying c-Kit in mouse models?

Yes, the c-Kit (D13A2) XP® Rabbit mAb has been shown to work effectively in mouse models, as indicated by its application in various studies, including those involving spermatogonial stem cell maintenance and differentiation in mice ().

Is this antibody suitable for immunofluorescence applications?

The c-Kit (D13A2) XP® Rabbit mAb has been utilized in immunofluorescence assays, as evidenced by its inclusion in studies examining the expression of c-Kit in different cellular contexts, including embryonic tissues ().

How does this antibody perform in Western blotting?

The c-Kit (D13A2) XP® Rabbit mAb has been successfully employed in Western blotting, where it has been used to detect c-Kit protein levels in various cancer cell lines, demonstrating its reliability for protein analysis ().

Are there specific conditions under which this antibody has been shown to enhance experimental outcomes?

In studies focusing on the SCF/c-Kit pathway, the inhibition of this pathway using specific inhibitors, including the c-Kit antibody, has been linked to radiosensitization in cancer cells under certain overexpression conditions, highlighting its potential in therapeutic applications ().

Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) YBX1 downregulation links to impaired spermatogonial stem cells function potentially through inhibiting miRNAs productioniScienceJune 19, 2026Ying Zhu, Genhong Mao, Xujing Geng, Qian Dou, Yungai Xiang, Liying Ma, Lei Wei, Li Tan,Cell Signaling Technology,Cat# 4202S; RRID:AB_1950384 c-Kit (D13A2) Rabbit Monoclonal Antibody,Cell Signaling Technology,Cat# 3074S; RRID:AB_1147633 PTEN (138G6) Rabbit Monoclonal Antibody,Cell Signaling Technology,Cat# 9559S; RRID:AB_390810 Akt

(2) Endothelial soluble APP/APLP2 promote heart repair through KIT-mediated angiogenesisSci AdvMay 22, 2026Haruya Kawase, Shangmin Liu, Sabrina Kurz, Verena Bengelsdorff, Remy Bonnavion, Young-June Jin, Kenneth Anthony Roquid, Haaglim Cho, Guozheng Liang, Marija Banićević, et al.4693159001) together with anti-KIT antibodies (clone D13A2; Cell Signaling Technology, catalog no. 3074; 1:50) or immunoglobulin G isotype control (clone DA1E; Cell Signaling Technology, catalog no. 3900;

(3) KIT-dependent acute myeloid leukemias are responsive to LSD1 inhibitionClin EpigeneticsMay 14, 2026Amal Kamal Abdel-Aziz, Mona Kamal SaadeldinProtein Assay (Catalog.No.500 − 0114) was purchased from Biorad. Primary antibodies against c-Kit (D13A2) XP® (3074), p-p70 S6 kinase (T389) (9234), total p70 S6K, p-4E-BP1 (T37/46) (2855), total 4E-BP1 (9644), p-pERK1/2

(4) TRNP1 regulates tumorigenesis and enhances immunotherapy response via c-Kit/STAT3 signaling in hepatocellular carcinomaJournal of Gastrointestinal OncologyApril 30, 2026Jian Hu, Ning Zhang, Yanfen Ma, Nian Zhou, Xiaoqian Wang, Kaige Zhang, Qian Wu, Xiaoqin Wang, Feifei Mao1 h and incubated overnight at 4 ℃ with the primary antibodies: TRNP1 (Abcam, 174303), c-Kit (CST, 3074S), STAT3 (CST, 9139S), phosphorylated STAT3 (Tyr705) (P-STAT3) (CST, 9145S), E-cadherin (CST, 14472S),

(5) Stemness and Survival: CD117+/CD133+ Subpopulations Sustain PI3K Signaling and Drive Imatinib Resistance in Head and Neck Mucosal MelanomaCellsApril 19, 2026Sofie-Yasmin Hassan, Simeon Santourlidis, Thomas W. Flanagan, Sarah-Lilly Hassan, He Zhou, Morna F. Schmidt, Claudio Cacchi, Matthias Ferdinand Lammert, Mossad Megahed, Amir Sadegh Yazdi, et al.immune fluorescence (IF) and immune histochemistry, including anti-CD117/c-Kit [(D13A2) XP® Rabbit mAb #3074], CD133 [(D2V8Q) XP® Rabbit mAb #64326], anti-CD133 (#64326), c-Kit (#37805), p85 (#4257), and Actin

(6) BRAF V600E Expression in c-Kit+ Interstitial Cells of Cajal Drives Gastrointestinal Stromal Tumor Formation in MiceCancer Research CommunicationsMarch 1, 2026Francesco Tomassoni-Ardori, Karlyne M. Reilly, Colleen Barrick, Robert Koogle, Elijah F. Edmondson, Sudhirkumar Yanpallewar, Dieter Saur, Brigitte C. Widemann, John W. Glod, Lino Tessarollo(20′),Thermo Fisher Scientific MA5-16358,1:25,AB_2537877 c-Kit,EDTA (20′),Cell Signaling Technology 3074,1:100,AB_1147633

(7) BRAF V600E Expression in c-Kit+ Interstitial Cells of Cajal Drives Gastrointestinal Stromal Tumor Formation in MiceCancer Res CommunMarch 1, 2026Francesco Tomassoni-Ardori, Karlyne M. Reilly, Colleen Barrick, Robert Koogle, Elijah F. Edmondson, Sudhirkumar Yanpallewar, Dieter Saur, Brigitte C. Widemann, John W. Glod, Lino Tessarollo(20′),Thermo Fisher Scientific MA5-16358,1:25,AB_2537877 c-Kit,EDTA (20′),Cell Signaling Technology 3074,1:100,AB_1147633

(8) Nbeal2 Inactivation Triggers Abl1 Stabilisation and Dysregulated Subcellular Localisation of the Multi‐Drug‐Resistant Protein MDR1 (ABCB1) in Mast CellsImmunologyFebruary 1, 2026Raphaela Marquardt, Nico Andreas, Ronja Herrnberger, Claudia Küchler, Katrin Hornung, Bernhard Nieswandt, Marco Groth, Paul M. Jordan, Oliver Werz, Julia Drube, et al.ABCB1 (#13978), tubulin (#3873), p‐tyrosine (Y) (#9411), pan‐pY‐416 SFK (#6943), Lyn (#2732), c‐Kit (#3074), Fyn (#4023), pAbl1 (#2861), Abl1 (#2862) (all from Cell Signalling Technology), NBEAL2 (ab187162)

(9) The critical role of the proto-oncogene c-Kit in TSC renal cystogenesisEMBO Molecular MedicineDecember 22, 2025Kamyar Zahedi, Sharon Barone, Marybeth Brooks, Wenzheng Zhang, Jane J Yu, Nathan A Zaidman, Manoocher Soleimani(rabbit polyclonal),Cell Signaling Technology,2217 c-KIT (rabbit polyclonal),Cell Signaling Technology,3074S H+-ATPase (mouse monoclonal),Santa Cruz Biotechnology,sc-55544 H+-ATPase (rabbit polyclonal),Generated

(10) Three-dimensional bioprinting of patient-derived Gastrointestinal stromal tumor: a novel platform for precision oncology and drug response profilingJournal of NanobiotechnologyDecember 18, 2025Liwei Du, Zicheng Zheng, Yanan Wang, Kai Zhang, Yuce Lu, Minghao Sun, Mingchang Pang, Shangze Jiang, Yixuan He, Shunda Du, et al.incubation overnight at 4 °C with primary antibodies: anti-KIT (1:1000, Cell Signaling Technology, 3074), anti-phospho-KIT (Tyr719) (1:1000, Cell Signaling Technology, 3391), anti-AKT (1:1000, Abclonal, A18675),

(11) Targeting yes-associated protein to overcome imatinib resistance in gastrointestinal stromal tumor drug-tolerant persister cellsGastric CancerNovember 1, 2025Takashi Yokouchi, Tsuyoshi Takahashi, Toshirou Nishida, Koji Tanaka, Yukinori Kurokawa, Kazuyoshi Yamamoto, Takuro Saito, Takaomi Hagi, Kota Momose, Kotaro Yamashita, et al.analysis Western blotting was conducted as described previously [19]. Antibodies used included c-KIT (D13A2, #3074), phospho-c-KIT (Tyr703, #3073), YAP (D8H1X, #14074), and phospho-YAP (Ser127, #13008). The secondary

(12) Cellular characterization of the mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cellseLifeSeptember 11, 2025Scott D Zawieja, Grace A Pea, Sarah E Broyhill, Advaya Patro, Karen H Bromert, Charles E Norton, Hae Jin Kim, Sathesh Kumar Sivasankaran, Min Li, Jorge A Castorena-Gonzalez, et al.(ACTA2) 1:500 (Sigma, A2547), anti-GFP 1:200 (Thermo Fisher, A11122), anti-cKIT 1:100 (Cell Signaling, 3074), anti-VIMENTIN 1:100 (Thermo Fisher, OMA1-06001), anti-desmin 1:200 (Invitrogen, PA5-16705), anti-GFP

(13) Cellular characterization of the mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cellsElifeSeptember 11, 2025Scott D Zawieja, Grace A Pea, Sarah E Broyhill, Advaya Patro, Karen H Bromert, Charles E Norton, Hae Jin Kim, Sathesh Kumar Sivasankaran, Min Li, Jorge A Castorena-Gonzalez, et al.(ACTA2) 1:500 (Sigma, A2547), anti-GFP 1:200 (Thermo Fisher, A11122), anti-cKIT 1:100 (Cell Signaling, 3074), anti-VIMENTIN 1:100 (Thermo Fisher, OMA1-06001), anti-desmin 1:200 (Invitrogen, PA5-16705), anti-GFP

(14) TFAP2A enhances tumor stemness and promotes metastasis in pancreatic ductal adenocarcinomaiScienceAugust 15, 2025Jiaxin Luo, Zezhi Ding, Dongjie Chen, Yongsheng Jiang, Yizhi Cao, Minmin Shi, Xiaomei Tang, Jia Liu, Meilin Xue, Zehui Zhang, et al.CD133 (Proteintech, 18470-1-AP), CD90 (Proteintech, 66766-1-Ig) or c-kit (Cell Signaling Technology, 3074) overnight at 4°C. HRP-labeled goat anti-mouse/rabbit IgG secondary antibodies were applied for 1 h

(15) Electroacupuncture with different current intensities can improve gastrointestinal motility in diabetic gastroparesis via vagal and sympathetic pathwaysWJDAugust 15, 2025Yi-Wen Tang, You Zhang, Jin Zhou, Yu-Ting Peng, Yan Zi, Yan-Rong Wei, Zeng-Hui Yueroom temperature for 1 hour. The sections were incubated with a primary antibody against C-kit (1:400, 3074T, Cell Signaling Technology, MA, United States) at 4 °C overnight, and washed three times with PBS for

(16) M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in CancerMolecular Cancer TherapeuticsJuly 2, 2025Christina Esdar, Nina Linde, Andreas Blum, Hanno Schieferstein, Christine Drechsler, Eva Sherbetjian, Carl Petersson, Edith Ross, Birgitta Leuthner, Ulrich Grädler, et al.(Cell Signaling Technology, cat #3073, RRID: AB_1147635) or a rabbit monoclonal KIT (Cell Signaling Technology, cat #3074, RRID: AB_1147633) and a PE-labeled donkey anti-rabbit antibody (Jackson ImmunoResearch, cat #711-116-152,

(17) Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinomaAutophagyJuly 1, 2025Shi H, Yang Y, Gao J, Kumar S, Xie H, Chen Z, Lyu J, Sihto H, Koljonen V, Vega-Rubin-de-Celis S, et al.antibodies,Immunoblotting - Primary antibodies KIT,Cell Signaling Technology,3308,"1:1,000" KIT,Cell Signaling Technology,3074,"1:1,000" p-Y719-KIT,Cell Signaling Technology,3391,"1:1,000" BECN1,Novus Biologicals/Bio-Techne Ltd,NB500–249,"1:1,000" MCPyV

(18) Electroacupuncture at ST36 ameliorates gastric dysmotility in rats with diabetic gastroparesis via the nucleus tractus solitarius-vagal axisWorld J GastroenterolJune 7, 2025You Zhang, Yi-Wen Tang, Jin Zhou, Yan-Rong Wei, Yu-Ting Peng, Zi Yan, Zeng-Hui Yuenitric oxide synthase (nNOS) (1:1500, 76067, Abcam), cluster of differentiation 117 (C-kit) (1:1000, 3074, Cell Signaling Technology), stem cell factor (SCF) (1:2500, 52603, Abcam), ChAT (1:1000, 178850, Abcam),

(19) Dyr726, a brain-penetrant inhibitor of PI3Kα, Type III receptor tyrosine kinases, and WNT signallingbioRxivMarch 31, 2025Vasudha Tandon, Alessandra Hope Fistrovich, Joaquina Nogales, Febe Ferro, Samantha N Rokey, Carly Rose Cabel, Amy Dunne Miller, Mary Yagle, Christina Duncan, Aditi Atmasidha, et al.MAPK (Tyr202/Y204),Cell Signaling Technology,Cat#: 4376 Anti-c-Kit,Cell Signaling Technology,Cat#: 3074 Anti-p-c-Kit (Tyr719),Cell Signaling Technology,Cat#: 3391 Anti-PDGFR,Cell Signaling Technology,Cat#:

(20) M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in CancerMol Cancer TherFebruary 28, 2025Christina Esdar, Nina Linde, Andreas Blum, Hanno Schieferstein, Christine Drechsler, Eva Sherbetjian, Carl Petersson, Edith Ross, Birgitta Leuthner, Ulrich Grädler, et al.(Cell Signaling Technology, cat #3073, RRID: AB_1147635) or a rabbit monoclonal KIT (Cell Signaling Technology, cat #3074, RRID: AB_1147633) and a PE-labeled donkey anti-rabbit antibody (Jackson ImmunoResearch, cat #711-116-152,

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c-Kit (D13A2) XP ® Rabbit mAb

c-Kit (D13A2) XP ® Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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c-Kit (D13A2) XP ® Rabbit mAb from Cell Signaling Technology

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