Phospho-Bim (Ser69) (D7E11) Rabbit mAb 4585S from Cell Signaling Technology

Product Specs
ItemPhospho-Bim (Ser69) (D7E11) Rabbit mAb
CompanyCell Signaling Technology
Price $401.00 Inquire
Catalog Number4585S
Quantity100 µl
ApplicationsW, IP
ReactivityH, M
TargetBim (Ser69) phosphate
ModificationsBim (Ser69) phosphate
HostRabbit
NCBI Gene AliasesBAM, BIM, BOD
ClonalityMonoclonal
NCBI Full Gene NameBCL2 like 11
Research AreaApoptosis
IsotypeIgG
CloneD7E11
Molecular Weight26

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) FBXO3-mediated DUSP9 ubiquitination promotes leukemia stem cell maintenance and tyrosine kinase inhibitor resistance in chronic myeloid leukemiaCell Rep MedMarch 17, 2026Xudong Li, Shiyu Zuo, Yanli Zhang, Zexing Liu, Na Shen, Qingqing Ma, Mingxia Sun, Binglei Zhang, Mengjia Li, Hong Huang, et al.antibody,Proteintech,Cat#22037-1-AP; RRID: AB_2878978 Phospho-Bim (Ser69) (D7E11) Rabbit mAb,Cell Signaling Technology,Cat#4585; RRID: AB_2065176 Phospho-Bim (Ser77) (D4H12) Rabbit mAb,Cell Signaling Technology,Cat#12433; RRID:

(2) Loss of EGF receptor polarity enables homeostatic imbalance in epithelial-cell modelsMolecular biology of the cellNovember 1, 2023Carlin CR, Ngalula S.number Actin,Mouse,CST,3700 BIM,Rabbit,CST,2933 BIM (pSer59),Rabbit,Invitrogen,PA5-105927 BIM (pSer69),Rabbit,CST,4585 E-cad,Mouse,BD Biosciences,61081 EGFR,Rabbit,CST,4405 EGFR (pTyr845),Rabbit,CST,6963 EGFR (pSer1046/47),Rabbit,CST,3777 EGFR

(3) GPR27 Regulates Hepatocellular Carcinoma Progression via MAPK/ERK PathwayCancer management and researchJanuary 1, 2022Wang H, Du D, Huang J, Wang S, He X, Yuan S, Xiao J.(Cambridge, MA, USA), Anti-Ras (#6704), anti-c-Raf (#9665), anti-phospho-c-Raf (#2933), anti-ERK1/2 (#4585), anti-phospho-ERK (#4370), anti-MEK (#2774), anti-phospho-MEK (#4661), anti-β-actin (#2146) were obtained

(4) Co-existing TP53 and ARID1A mutations promote aggressive endometrial tumorigenesisPLoS geneticsDecember 1, 2021Reske JJ, Wilson MR, Holladay J, Siwicki RA, Skalski H, Harkins S, Adams M, Risinger JI, Hostetter G, Lin K, et al.antibodies at the following dilutions: 1:200 ARID1A (D2A8U) (12354, Cell Signaling); 1:400 Phospho-S6 (4585, Cell Signaling); 1:100 KRT8 (TROMA1, DHSB); 1:200 Cleaved Caspase-3 (9579, Cell Signaling); 1:400 Ki67

(5) Activation of mTOR mediates hyperglycemia-induced renal glomerular endothelial hyperpermeability via the RhoA/ROCK/pMLC signaling pathwayDiabetology & metabolic syndromeOctober 9, 2021Chen X, Chen J, Li X, Yu Z.(3674), MLC (8505), phospho-mTOR (2971), mTOR (2983), α-tubulin (3873), GAPDH (2118), phospho-RPS6 (4585), and RPS6 (2217); the RhoA Activation Assay Kit (8789); and rapamycin (8789) were purchased from Cell Signaling Technology

(6) White Adipose Tissue Autophagy and Adipose-Liver Crosstalk Exacerbate Nonalcoholic Fatty Liver Disease in MiceCellular and Molecular Gastroenterology and HepatologyJuly 22, 2021Sadatsugu Sakane, Hayato Hikita, Kumiko Shirai, Yuta Myojin, Youichi Sasaki, Shinnosuke Kudo, Kenji Fukumoto, Naoki Mizutani, Yuki Tahata, Yuki Makino, et al.Bim (C34C5) Rabbit mAb,Cell Signaling Technology,#2933 Phospho-Bim (Ser69) (D7E11) Rabbit mAb,Cell Signaling Technology,#4585 Bid Antibody (Mouse Specific),Cell Signaling Technology,#2003 Puma (D7L9L) Rabbit mAb (Rodent Specific),Cell Signaling Technology

(7) ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer HyperacetylationCell reportsNovember 10, 2020Wilson MR, Reske JJ, Holladay J, Neupane S, Ngo J, Cuthrell N, Wegener M, Rhodes M, Adams M, Sheridan R, et al.1:200 ARID1A (D2A8U) (12354, Cell Signaling); 1:1000 P300 (86377, Cell Signaling); 1:400 Phospho-S6 (4585, Cell Signaling); 1:100 KRT8 (TROMA1, DHSB); 1:200 Cleaved Caspase-3 (9579, Cell Signaling); 1:400 Ki67

(8) Cdkn2a Loss in a Model of Neurofibroma Demonstrates Stepwise Tumor Progression to Atypical Neurofibroma and MPNSTCancer researchNovember 1, 2020Chaney KE, Perrino MR, Kershner LJ, Patel AV, Wu J, Choi K, Rizvi TA, Dombi E, Szabo S, Largaespada DA, et al.and peripheral nerve from 2-month-old mice, and immediately froze tissue in OCT (Fisher Healthcare, 4585). We cut, air dried, and stained 10um tissue section with a β-galactosidase senescence Cell Signaling

(9) JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD inductionCell death and differentiationOctober 1, 2020Simula L, Corrado M, Accordi B, Di Rita A, Nazio F, Antonucci Y, Di Daniele A, Caicci F, Caruana I, Soriano ME, et al.anti-ERK1/2 (Cell Signaling 4695), anti-Bim (Cell Signaling 2933), anti-pSer69-Bim (Cell Signaling 4585), anti-Flag (Sigma F1804), anti-GAPDH (Cell Signaling 2118), anti-Hsp90 (Cell Signaling 4877), anti-OMA1

(10) Sepiapterin reductase promotes hepatocellular carcinoma progression via FoxO3a/Bim signaling in a nonenzymatic mannerCell death & diseaseApril 20, 2020Wu Y, Du H, Zhan M, Wang H, Chen P, Du D, Liu X, Huang X, Ma P, Peng D, et al.(Cambridge, MA, USA). Anti-PARP (#6704), anti-Caspase 3 (#9665), anti-Bim (#2933), anti-phospho-Bim (#4585), anti-Bax (#2774), anti-phospho-Erk (#4370), anti-VDAC (#4661), anti-β-Tubulin (#2146), and anti-Lamin

(11) MAGE-A inhibit apoptosis and promote proliferation in multiple myeloma through regulation of BIM and p21(Cip1)OncotargetFebruary 18, 2020Mei AH, Tung K, Han J, Perumal D, Laganà A, Keats J, Auclair D, Chari A, Jagannath S, Parekh S, et al.(Cell Signaling Technologies, 2872), Bcl-xL (2762), BID (2002), BIM (2819), CoxIV (4850), Mcl-1 (4572), pSer69-BIM (4585), pSer77-BIM (12433), p21 (2947), BMF (Abcam, ab181148), GAPDH (ab8245), Bcl-G (Santa Cruz, sc-393715),

(12) ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasionNature communicationsAugust 7, 2019Wilson MR, Reske JJ, Holladay J, Wilber GE, Rhodes M, Koeman J, Adams M, Johnson B, Su RW, Joshi NR, et al.antibodies at the following dilutions: 1:200 ARID1A (D2A8U) (12354, Cell Signaling); 1:400 Phospho-S6 (4585, Cell Signaling); 1:100 KRT8 (TROMA1, DHSB); 1:100 EPCAM (G8.8-s, DHSB); 1:400 PGR (SAB5500165, Sigma).

(13) Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient–Derived Xenograft Models and BIM Levels Are Predictive of ResponsivenessMolecular Cancer TherapeuticsMarch 1, 2019Claudia Iavarone et al.proteins. Western blotting experiments were performed using BIM antibody (CST, 2933S), p-BIMS69 (CST, 4585S), p-ERKT202/T204 (Sigma, M9692), total-ERK (CST, 9102S), cleaved caspase 3 (CST, 9661L); NOXA (CST,

(14) Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancerNature medicineJanuary 1, 2019Shah KN, Bhatt R, Rotow J, Rohrberg J, Olivas V, Wang VE, Hemmati G, Martins MM, Maynard A, Kuhn J, et al.AKT (9272), PARP (5625), pAURKA (T288; 3079), AURKA (4718) pRb (S780; 9307), BIM (2933), pBIM (S69; 4585), BAX (5023), Vimentin (5741), p-p65 (S536; 3033), p65 (8242), Pan phospho-AURKA/B/C (T288/T232/T198;

(15) Gene prioritization, communality analysis, networking and metabolic integrated pathway to better understand breast cancer pathogenesisScientific ReportsDecember 1, 2018AndrÃ©s LÃ³pez-CortÃ©s, CÃ©sar Paz-y-MiÃ±o, Alejandro Cabrera-Andrade, Stephen J. Barigye, Cristian R. Munteanu, Humberto GonzÃ¡lez-DÃaz, Alejandro Pazos, Yunierkis PÃ©rez-Castillo, Eduardo TejeraInvasion, and Anoikis Involvement of Ras Activation in Human Breast Cancer Cell Signaling, Invasion, 4585–4592, https://doi.org/10.1158/0008-5472.CAN-04-0396 (2004). 49. Santen, R. J. et al. The role of mitogen-activated

(16) Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER StressCell reportsOctober 9, 2018González-García I, Contreras C, Estévez-Salguero Á, Ruíz-Pino F, Colsh B, Pensado I, Liñares-Pose L, Rial-Pensado E, Martínez de Morentin PB, Fernø J, et al.

(17) The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell CarcinomaCancer cellMay 14, 2018Momcilovic M, Bailey ST, Lee JT, Fishbein MC, Braas D, Go J, Graeber TG, Parlati F, Demo S, Li R, et al.1:1000), anti-Ki67 (SP6) (Thermo Scientific, RM-9106-S0 1:200), phospho-S6 (Cell Signaling Technology, #4585 1:400), phospho-GSK3α/β (Ser21/9) (Cell Signaling Technology, #9331 1:50), c-Jun (Cell Signaling Technology,

(18) JNK1 as a signaling node in VDR-BRAF induction of cell death in AMLThe Journal of Steroid Biochemistry and Molecular BiologyMarch 1, 2018Xuening Wang, William K Beute, Jonathan S Harrison, George P StudzinskiPhospho-p38 MAPK (Thr180/Tyr182, #4511), Phospho-C-JUN (Ser63, #2631), C-JUN (#9165), Phospho-BIM (Ser69, #4585), Phospho-H2AX (Ser139, #9718), FOXO3a (#2497), cleaved Caspase 9 (#9505), cleaved caspase 3 (#9661)

(19) HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosisCell Death & DiseaseAugust 1, 2017Donna Kennedy et al.probed with specific antibodies for: ACTIN (Sigma, A2066, 1 : 5000), p- BIM (CST, Danvers, MA, USA, #4585, 1 : 1000), BIM (Stressgen, Farmingdale, NY, USA, ADI-AAP-330, 1 : 2000), Caspase-3 (CST, #9662, 1 : 1000

(20) The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosisEMBO reportsMay 1, 2016Weber A, Heinlein M, Dengjel J, Alber C, Singh PK, Häcker G.b-TrCP (D13F10, #4394), Bcl-XL (54H6, #2764), Bim (C34C5, #2933), phosphoBim (Ser69)-specific antibody (D7E11, #4585), Flag (#2368), GFP (D5.1, #2956), phospho-p44/42 MAPK (Erk1/2, #4370), HA-tag antibody (C29F4, #3724),

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Phospho-Bim (Ser69) (D7E11) Rabbit mAb

Phospho-Bim (Ser69) (D7E11) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

Citations (27)

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Phospho-Bim (Ser69) (D7E11) Rabbit mAb from Cell Signaling Technology

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