SAS-6 (91.390.21) Antibody from Santa Cruz Biotechnology, Inc.

The SAS-6 antibody has been shown to work in applications such as Western blotting, immunofluorescence, and immunoprecipitation. It has been utilized in studies investigating centriole assembly and stability, as well as in the analysis of centriole-related defects in various cellular contexts, including those related to ciliopathies and cancer.

Yes, the SAS-6 antibody has been referenced in studies examining centriole structural integrity defects associated with diseases such as Hydrolethalus Syndrome. In these studies, the antibody was used to analyze the role of SAS-6 in centriole assembly and its implications for cilia function and related phenotypes.

The SAS-6 antibody is reactive with multiple species, including humans, mice, and rats. This broad reactivity allows researchers to use it in comparative studies across different model organisms to investigate centriole biology.

The SAS-6 antibody has been instrumental in elucidating the mechanisms of centriole biogenesis. For instance, it has been used to demonstrate the role of SAS-6 in forming the cartwheel structure essential for centriole assembly, as well as in studies that explore the interactions between SAS-6 and other proteins involved in centriole duplication and stability.