Supplier Page from Novus Biologicals, a Bio-Techne Brand for Cytochrome b245 alpha Antibody (CS9) [Alexa Fluor® 488]
Available conjugates: Available conjugates: DyLight 755, PE/Cy7, Biotin, DyLight 680, PerCP, Alexa Fluor 405, mFluor Violet 450 SE, Alexa Fluor 488, Janelia Fluor 646Specificity: This antibody recognises the light chain of cytochrome B245, also known as p22phox, a subunit of the nicotinamide adenine dinucleotide phosphate-oxidase (NADPH oxidase). NADPH oxidase is a membrane-bound enzyme complex in neutrophils that produces the superoxide anion (O2-) by transferring single electrons from NADPH inside the cell across the membrane and coupling them to molecular oxygen. Superoxide is used for the destruction of pathogens. Individuals with defects in NADPH oxidase suffer from chronic granulomatous disease, characterised by severe recurrent infections.Sizes Available: 0.1 ml