IRF-1 (H-8) Antibody sc-74530 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemIRF-1 (H-8) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-74530
Antibody TypePrimary Antibodies
CloneH-8
Quantity200 µg/ml
Reactivityhuman
ApplicationsWB, IP, IF, ELISA
ClonalityMonoclonal
FormatPurified
Hostmouse
Conjugate/TagUnconjugated
NCBI Gene AliasesIRF-1, MAR
NCBI Full Gene Nameinterferon regulatory factor 1
TargetIRF-1
IsotypeIgG1

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Targeting SUMOylation triggers interferon-ß-dependent activation of patient and allogenic Natural Killer cells in preclinical models of Acute Myeloid LeukemiaMolecular Cancer TherapeuticsJuly 29, 2025Rawan Hallal, Marion de Toledo, Denis Tempé, Rayane Berrahouane, Sara Zemiti, Loïs Coënon, Delphine Gitenay, Simon George, Moritz Schüssler, Nadine Laguette, et al.(8A2) were obtained from the Developmental Studies Hybridoma Bank. IRF-1 antibody was from Santa-Cruz (sc-74530), IRF-3 (D83B9) and MDA-5 (D74E4) from Cell Signaling, IRF-7 from ProteinTech (#22392). Generation

(2) Grainyhead-like-2, an epithelial master programmer, promotes interferon induction and suppresses breast cancer recurrenceMolecular ImmunologyJune 1, 2024Ian MacFawn, Joshua Farris, Phillip Pifer, Naira V. Margaryan, Halima Akhter, Lei Wang, Sebastian Dziadowicz, James Denvir, Gangqing Hu, Steven M. Frisch,Cell Signaling Technologies,11904 P-IRF3 (386),WB,Cell Signaling Technologies,37829 IRF-1,WB,Santa Cruz Biotechnology,Sc-74530 relA/p65,WB,Cell Signaling Technologies,8242 P-relA/p65,WB,Cell Signaling Technologies,3033 TBK1,WB,Cell Signaling Technologies

(3) The mammalian midbody and midbody remnant are assembly sites for RNA and localized translationDevelopmental cellOctober 9, 2023Park S, Dahn R, Kurt E, Presle A, VanDenHeuvel K, Moravec C, Jambhekar A, Olukoga O, Shepherd J, Echard A, et al.

(4) Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapyNature communicationsApril 6, 2023Yi J, Tavana O, Li H, Wang D, Baer RJ, Gu W.

(5) Disrupting the phase separation of KAT8-IRF1 diminishes PD-L1 expression and promotes antitumor immunityNature cancerMarch 1, 2023Wu Y, Zhou L, Zou Y, Zhang Y, Zhang M, Xu L, Zheng L, He W, Yu K, Li T, et al.

(6) Survivin promotes a glycolytic switch in CD4(+) T cells by suppressing the transcription of PFKFB3 in rheumatoid arthritisiScienceDecember 22, 2022Erlandsson MC, Andersson KME, Oparina NY, Chandrasekaran V, Saghy T, Damdimopoulos A, Garcia-Bonete MJ, Einbeigi Z, Silfverswärd ST, Pekna M, et al.inhibitors. IP was performed with antibodies recognizing Survivin (ab192675, Abcam, Cambridge, UK), IRF1 (sc74530, Santa Cruz Biotechnology), and SMAD3 (sc101154, Santa Cruz Biotechnology) using the Dynabeads Protein G Immunoprecipitation Kit

(7) IFNγ-induced PD-L1 expression in ovarian cancer cells is regulated by JAK1, STAT1 and IRF1 signalingCellular signallingSeptember 1, 2022Padmanabhan S, Gaire B, Zou Y, Uddin MM, Vancurova I.

(8) Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging virusesCell chemical biologyJuly 21, 2022Maarifi G, Martin MF, Zebboudj A, Boulay A, Nouaux P, Fernandez J, Lagisquet J, Garcin D, Gaudin R, Arhel NJ, et al.,Cell Signaling Technology,Cat# 5321; RRID: AB_10694490 "Mouse anti-IRF1, clone H8",Santa Cruz Biotechnology,Cat# sc-74530; RRID: AB_2126826 "Rabbit anti-IRF3, clone D6I4C",Cell Signaling Technology,Cat# 11904; RRID: AB_2722521 "Rabbit

(9) Inhibition of GFAT1 in lung cancer cells destabilizes PD-L1 proteinCarcinogenesisOctober 5, 2021Chen W, Saxton B, Tessema M, Belinsky SA.

(10) Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia CellsCellsNovember 5, 2020Albanesi J, Noguera NI, Banella C, Colangelo T, De Marinis E, Leone S, Palumbo O, Voso MT, Ascenzi P, Nervi C, et al.

(11) Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platformsNature immunologyAugust 1, 2020Wandel MP, Kim BH, Park ES, Boyle KB, Nayak K, Lagrange B, Herod A, Henry T, Zilbauer M, Rohde J, et al.R&D Systems (for IF: Galectin-8 AF1305), Santa Cruz Biotechnology (Caspase-1 C-20 sc-515, IRF-1 H-8 sc-74530, PCNA PC10 sc-56, STAT1 C-111 sc-417), Sigma (for IF: FLAG-tag M2 F1804, for western blots: FLAG-tag

(12) Prolactin activates IRF1 and leads to altered balance of histone acetylation: Implications for systemic lupus erythematosusModern rheumatologyMay 1, 2020Leung YT, Maurer K, Song L, Convissar J, Sullivan KE.

(13) Interferon regulatory factor-1 suppresses DNA damage response and reverses chemotherapy resistance by downregulating the expression of RAD51 in gastric cancerAmerican journal of cancer researchJanuary 1, 2020Tan L, Yuan J, Zhu W, Tao K, Wang G, Gao J.

(14) Interferon regulatory factor-1 reverses chemoresistance by downregulating the expression of P-glycoprotein in gastric cancerCancer lettersAugust 10, 2019Yuan J, Yin Z, Tan L, Zhu W, Tao K, Wang G, Shi W, Gao J.

(15) MIR17HG-miR-18a/19a axis, regulated by interferon regulatory factor-1, promotes gastric cancer metastasis via Wnt/β-catenin signallingCell death & diseaseJune 11, 2019Yuan J, Tan L, Yin Z, Zhu W, Tao K, Wang G, Shi W, Gao J.

(16) Endotoxin tolerance in monocytes can be mitigated by α2-interferonJournal of leukocyte biologyOctober 1, 2015Shi L, Song L, Maurer K, Sharp J, Zhang Z, Sullivan KE.

(17) Interferon regulatory factor 1 marks activated genes and can induce target gene expression in systemic lupus erythematosusArthritis & rheumatology (Hoboken, N.J.)March 1, 2015Zhang Z, Shi L, Song L, Ephrem E, Petri M, Sullivan KE.

(18) IκB kinase ε targets interferon regulatory factor 1 in activated T lymphocytesMolecular and cellular biologyMarch 1, 2014Sgarbanti M, Marsili G, Remoli AL, Stellacci E, Mai A, Rotili D, Perrotti E, Acchioni C, Orsatti R, Iraci N, et al.proteins were probed with a polyclonal Ab against RelA (sc-109) and a monoclonal Ab against IRF-1 (sc-74530), from Santa Cruz Biotechnology Inc. (Santa Cruz, CA). Input extracts were blotted with polyclonal antibodies

(19) SAHA down-regulates the expression of indoleamine 2,3-dioxygenase via inhibition of the JAK/STAT1 signaling pathway in gallbladder carcinoma cellsOncology reportsJanuary 1, 2013Zhang P, Jiang G, Gao J, Li L, Du J, Jiao X.

(20) CIITA is silenced by epigenetic mechanisms that prevent the recruitment of transactivating factors in rhabdomyosarcoma cellsInternational journal of cancerAugust 15, 2012Londhe P, Zhu B, Abraham J, Keller C, Davie J.

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IRF-1 (H-8) Antibody

IRF-1 (H-8) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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IRF-1 (H-8) Antibody from Santa Cruz Biotechnology, Inc.

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