Biorbyt's CD261 antibody monoclonal antibody. The CD261 antibody was generated using TNFRSF10A as the antigen. It reacts with Homo Sapiens, and Human. This antibody has been shown to work in applications such as: Precipitation, Flow Cytometry, Immunocytochemistry, and Immunoprecipitation.
Description
Mouse monoclonal antibody to CD261 which is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to activated CD261 which is expressed in most human tissues including spleen, peripheral blood leucocytes, thymus and in a variety oFT tumour-derived cell lines. It plays a role in inducing cell death. The binding oFT TRAIL to DR4 triggers the activation oFT pro-caspases 8 and 10, leading to apoptosis