APC anti-mouse CD4 116013 from BioLegend

Product Specs
ItemAPC anti-mouse CD4
CompanyBioLegend
Price $78.00Supplier Page View Company Product Page
Catalog Number116013
Quantity25 µg
ApplicationsFC - Quality tested
Concentration0.2mg/ml
Conjugate/TagAPC
FormatPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
ReactivityMouse
IsotypeRat IgG2b, kappa
CloneRM4-4
HostRat
Antibody TypePrimary
ImmunogenBALB/c mouse thymocytes
NCBI Full Gene NameCD4 antigen
NCBI Gene AliasesL3T4, Ly-4
ClonalityMonoclonal
TargetCD4

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BioLegend

8999 BioLegend Way

San Diego, California 92121

United States

Phone: 1-877-246-5343 Toll-Free, USA & Canada
1-858-768-5800 International
Fax: 1-877-455-9587

Company Profile

Website: biolegend.com

(1) Dihydrotanshinone l alleviates psoriasis-like skin lesion via suppressing STAT3 signaling and DCs-Th17 responsesRSC AdvJuly 22, 2026Luoming Zhang, Xiaoyue Qi, Baodong Ma, Ranran Jin, Yiming Shao, Yaoxin Gaoanti-CD45 mAb (147715, BioLegend, USA), FITC anti-CD3 mAb (100204, BioLegend, USA), and APC anti-CD4 mAb (116013, BioLegend, USA), APC anti-CD11c mAb (BioLegend, 117305, USA), PE anti-CD40 mAb (BioLegend, 124609,

(2) Innate immune priming by n-dodecyl-β-D-maltoside in murine models of bacterial and viral infectioneBioMedicineFebruary 1, 2026Jisun Park, Jihyun Yang, Seonghan Jang, Tae-Won Kim, Suhyeon Heo, Jieun Seo, Sangwon Byun, Choong-Min Ryu, Hwi Won Seo100204; RRID:AB_312661); or 0.25 μg of APC anti-mouse CD4 antibody per 106 cells (BioLegend, Cat. No. 116014; RRID:AB_2563025). After staining, the cells were washed twice with 2 mL of EasySep™ buffer by centrifugation

(3) Anhydroicaritin-loaded mesenchymal stem cell exosomes ameliorate psoriasis via ACSL4-mediated ferroptosis in miceCommunications BiologyJanuary 23, 2026Yaoxin Gao, Baodong Ma, Ranran Jin, Yiming Shao, Luoming Zhang, Xiaoyue Qi, Qiurui He, Qinjun Chu, Zhengyuan Xiaanti-CD45 mAb (147715, BioLegend, USA), FITC anti-CD3 mAb (100204, BioLegend, USA), APC anti-CD4 mAb (116013, BioLegend, USA), FITC anti-CD34 hAb (343503, BioLegend, USA), FITC anti-CD45 hAb (982316, BioLegend,

(4) Variation in Microbiome Composition and Faecal Metabolites Are Associated With Differential Susceptibility to DSS ‐Induced ColitisImmunologyDecember 9, 2025Jessica M. Till, Orion D. Brock, Elyza A. Do, Morgan J. Engelhart, Robert W. P. Glowacki, Shaomin Hu, Ansel Hsiao, Ina Nemet, Philip P. Ahernmanufacturer's instructions),Biolegend,423102 Anti‐mouse CD4,APC,"Rat IgG2b, κ",RM4‐4,0.67,Biolegend,116013 Anti‐mouse CD4,BV605,"Rat IgG2a, κ",RM4‐5,0.67,Biolegend,100548 Anti‐mouse CD4,e450,"Rat IgG2a, κ",RM4‐5,0.67,Invitrogen,48‐0042‐82 Anti‐mouse

(5) Reprogramming of cancer metabolism via photoresponsive nano-PROTAC enhances pyroptosis-mediated immunotherapySignal Transduction and Targeted TherapySeptember 26, 2025Byeongmin Park, Jiwoong Choi, Jae-Hyeon Lee, Yelee Kim, Woohyeong Lee, Ansoo Lee, In-Cheol Sun, Hong Yeol Yoon, Yongju Kim, Sun Hwa Kim, et al.No. 100217, Biolegend; CD8+, Cat. No. 100712, Biolegend) and regulatory T cells (CD3+; CD4+, Cat. No. 116013, Biolegend; CD25+, Cat. No. 101904, Biolegend). In the coculture medium, TNF-α (Cat. No. MTA00b-1, R&D Systems

(6) Spleen-targeted NeoPol-mL242 mRNA vaccine induces robust T-cell responses in a hepatocellular carcinoma modelJournal of NanobiotechnologySeptember 2, 2025Yufei Wu, Gongrui Sun, Wendan Ren, Yang Gui, Cong Wang, Xinyi Ye, Yun Chen, Xiufeng Pang, Qi Zhang, Zi Jun Wang, et al.antibody (BioLegend, 100203), allophycocyanin (APC)-conjugated anti-mouse CD4 antibody (BioLegend, 116013), peridinin-chlorophyll-protein complex (PerCP)/Cyanine5.5-conjugated anti-mouse CD19 antibody (BioLegend,

(7) Metabolic adaptations direct cell fate during tissue regenerationNatureJune 11, 2025Almudena Chaves-Perez, Scott E. Millman, Sudha Janaki-Raman, Yu-Jui Ho, Clemens Hinterleitner, Valentin J. A. Barthet, John P. Morris, Francisco M. Barriga, Jose Reyes, Aye Kyaw, et al.and 2 mM EDTA in Ca2+/Mg2+-free PBS) and incubated on ice for 30 min with anti-CD4–APC (BioLegend, 116014, clone RM4-4, 1:200) and anti-CD45Rb–FITC (BioLegend, 103306, clone C363-16A, 1:200) antibodies. CD4+CD45Rbhigh

(8) Functional tendon regeneration is driven by regulatory T cells and IL-33 signalingScience advancesApril 25, 2025Arvind V, Crosio G, Howell K, Zhang H, Montero A, Huang AH.stained with Sytox Blue (Thermo Fisher Scientific, catalog no. S11348), CD4 (BioLegend, catalog no. 116013), and GFP (BioLegend, catalog no. 338003). The anti-GFP antibody was added for straightforward detection

(9) The m6A Reader HNRNPC Is a Key Regulator in DSS-Induced Colitis by Modulating Macrophage PhenotypeiScienceMarch 21, 2025Xiaohui Fang, Yu Zhang, Ziliang Ke, Yang Zhang, Yiken Lin, Yibo Huang, Jianhua Zhou, Huiting Su, Jun Xu, Yulan LiuAB_2894427 PE anti-mouse CD3,Biolegend,Cat# 100205; RRID: AB_312662 APC anti-mouse CD4,Biolegend,Cat# 116013; RRID: AB_2563024 PE/Cyanine7 anti-mouse CD8a,Biolegend,Cat# 100721; RRID: AB_312760 APC/Cyanine7 anti-mouse/human CD45R/B220

(10) Impact of exosomes derived from adipose stem cells on lymphocyte proliferation and phenotype in mouse skin graftsExtracellular Vesicles and Circulating Nucleic AcidsMarch 7, 2025Xinqiang Li, Xueteng Wang, Hailun Cai, Ye Wang, Xin Zhou, Bin Wu, Jinzhen Cai, Dahong TengPerCP/Cy5.5/Cyanine5.5 anti-mouse CD3 Antibody (Biolegend, 100218); APC anti-mouse CD4 Antibody (Biolegend, 116014); APC/Cyanine7 anti-mouse CD8a Antibody (Biolegend, 100714); RBC Lysis Buffer (10X) (Biolegend, 420301);

(11) Potent efficacy of an IgG-specific endoglycosidase against IgG-mediated pathologiesCellNovember 27, 2024Diego E. Sastre, Stylianos Bournazos, Jonathan Du, E. Josephine Boder, Julia E. Edgar, Tala Azzam, Nazneen Sultana, Maros Huliciak, Maria Flowers, Lea Yoza, et al.109806 anti-mouse CD11b (clone M1/70)-PE-Cy7,BioLegend,Cat# 101215 anti-mouse CD4 (clone RM4-4)-APC,Biolegend,Cat# 116014 anti-mouse CD3 (clone 17A2)-AlexaFluor700,invitrogen,Cat# 56-0032-82 anti-mouse CD45 (clone 30-F11)-BrilliantViolet605,BioLegend,Cat#

(12) Aberrant zonal recycling of germinal center B cells impairs appropriate selection in lupusCell ReportsNovember 26, 2024Gina M. Sanchez, Eden S. Hirsch, Arthur VanValkenburg, Daniel P. Mayer, Komi Gbedande, Rebecca L. Francis, Wenzhi Song, Olivia Q. Antao, Kyleigh E. Brimmer, Alexander Lemenze, et al.PC/Cy7,BioLegend,115520;RRID:AB_313655 CD38 AF700,BioLegend,102741;RRID:AB_2890672 CD4 APC,BioLegend,116014;RRID:AB_2563025 CD40 APC,Thermo,17-1541-81;RRID:AB_795824 CD44 APC/Cy7,BioLegend,103028;RRID:AB_2852399 CD44

(13) Chaperonin‐containing TCP1 subunit 6A inhibition via TRIM21‐mediated K48‐linked ubiquitination suppresses triple‐negative breast cancer progression through the AKT signalling pathwayClinical and Translational MedicineNovember 18, 2024Mengdi Yang, Jianing Cao, Tiantian Liu, Bin Li, Jinyan Wang, Shuangyue Pan, Duancheng Guo, Zhonghua Tao, Xichun HuFixable Viability Kit (#423101, Biolegend) and antibodies targeting CD45 (#103115, Biolegend), CD4 (#116013, Biolegend), CD8a (#100733, Biolegend), PD1 (#135217, Biolegend) and CTLA4 (#106305, Biolegend). All

(14) Polytrauma impairs fracture healing accompanied by increased persistence of innate inflammatory stimuli and reduced adaptive responseJournal of Orthopaedic ResearchNovember 17, 2024Augustine Mark Saiz, Maryam Rahmati, Robert Charles Henry Gresham, Tony Daniel Baldini, Jane Burgan, Mark A. Lee, Benjamin Osipov, Blaine A. Christiansen, Thaqif El Khassawna, D. C. Florian Wieland, et al.65086514), CD45 (BioLegend, 103139), CD19 (BioLegend, 115554), CD3 (BioLegend, 100205), CD4 (BioLegend, 116014), CD8 (BioLegend, 344733), CD11b (BioLegend, 301356), Lys6G (BioLegend, 127612), F4/80 (BioLegend, 123114),

(15) Blockade of TGF-β and PD-L1 by bintrafusp alfa promotes survival in preclinical ovarian cancer models by promoting T effector and NK cell responsesBritish journal of cancerJune 1, 2024Kment J, Newsted D, Young S, Vermeulen MC, Laight BJ, Greer PA, Lan Y, Craig AW.clone DX5). These antibody panels were expanded further to incorporate staining of: CD4-APC (Biolegend 116013, clone RM4-4), LAMP-1/CD107a-PE (Biolegend 121611, clone 1D4B), CD27-BV605 (Biolegend 124249, clone

(16) Immunomodulatory effect of PLGA-encapsulated mesenchymal stem cells-derived exosomes for the treatment of allergic rhinitisFrontiers in immunologyJanuary 1, 2024Shahzad KA, Wang Z, Li X, Li J, Xu M, Tan F.manufacturer’s protocol. The isolated lymphocytes were stained by surface staining with anti-mouse APC-CD4 (Cat#116014, Biolegend), FITC-CD19 (Cat#152404, Biolegend) and PE/Cyanine7-CD25 (Cat#102016, Biolegend) for 30min

(17) Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathwaysCell reportsJuly 25, 2023Ganapathy AS, Saha K, Wang A, Arumugam P, Dharmaprakash V, Yochum G, Koltun W, Nighot M, Perdew G, Thompson TA, et al.tagged,"Biolegend, San Diego, CA",Cat# 103306; RRID:AB_313013 Anti-CD4-APC tagged,"Biolegend, San Diego, CA",Cat# 116014; RRID:AB_2563025 Goat anti-mouse HRP tagged secondary antibody,"Abcam, Boston, MA",Cat# AB205719; RRID:AB_2755049 Goat

(18) CD4(+) T cells aggravate hemorrhagic brain injuryScience advancesJune 9, 2023Shi SX, Xiu Y, Li Y, Yuan M, Shi K, Liu Q, Wang X, Jin WN.otherwise indicated. Antibodies used were as follows: CD45-APC-Cy7 (30-F11, 103116), CD4-APC (RM4-4, 116013), CD4-PE (GK1.5, 100408), CD3–fluorescein isothiocyanate (FITC) (17A2, 100204), CD3-PE (17A2, 100205),

(19) Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell developmentNature immunologyMarch 1, 2023Scherer S, Oberle SG, Kanev K, Gerullis AK, Wu M, de Almeida GP, Puleston DJ, Baixauli F, Aly L, Greco A, et al.

(20) IL-17A aggravates asthma-induced intestinal immune injury by promoting neutrophil traffickingJournal of leukocyte biologySeptember 1, 2022Hong Y, Chu Z, Kong J, Li Q, Li N, Liu L, Wu T, Liu J, Ge D, Li J, et al.

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APC anti-mouse CD4 from BioLegend

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APC anti-mouse CD4 from BioLegend

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