NPM1 (mutant) Antibody PA1-46356 from Thermo Fisher Scientific

Product Specs
ItemNPM1 (mutant) Antibody
CompanyThermo Fisher Scientific
Price Supplier Page
Catalog NumberPA1-46356
NCBI Gene AliasesNO38, Npm, NPM, B23
Conjugate/TagUnconjugated
ApplicationsImmunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
ClonalityPolyclonal
Quantity100 µL
ReactivityHuman, Mouse
TargetNPM1 (mutant)
FormatPBS with 0.02% sodium azide; pH 7.4
HostRabbit
NCBI Full Gene Namenucleophosmin 1
Concentration1 mg/mL
ImmunogenA synthetic peptide made to a C-terminal region of human mutant Nucleophosmin (within residues 250-294)
IsotypeIgG
PurityAntigen affinity chromatography
Antibody TypePrimary
StorageStore at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles

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Thermo Fisher Scientific

81 Wyman Street

Waltham, MA 02451

United States

Phone: 800-678-5599
Fax: 800-331-2286

Company Profile

Website: www.thermofisher.com

(1) Frequent NPM1 mutation, monoblastic/monocytic origin and prognostic significance of organ and system involvement in myeloid sarcoma: a multicenter studyJ Pathol Clin ResMarch 4, 2026Alex Jenei, Béla Kajtár, Tamás László, Hazem A Juratli, Livia Vida, Ágota Szepesi, Réka Mózes, Botond Timár, Jörg Halter, Stefan Dirnhofer, et al.min Lysozyme,Rabbit polyclonal,Ventana 760‐2656,RTU,CC1 8 min,16 min mut NPM1,Rabbit polyclonal,Invitrogen PA1‐46356,1:800,CC1 32 min,24 min PD1,Clone NAT105,Ventana 760‐4895,RTU,CC1 48 min,12 min PDL1,E1L3N,Cell signaling

(2) The Novel Imiqualine EAPB02303 Is a Potent Drug for Treating Acute Myeloid LeukemiaBiomoleculesMay 20, 2025Perla Makhoul, Rita Hleihel, Shaymaa Itani, Maguy Hamie, Stephanie Pagniagua-Gayraud, Cindy Patinote, Myriam Richaud, Raghida Abou Merhi, Marwan El-Sabban, Simon Galas, et al.,Cell Signaling Technology Anti-nucleophosmin antibody [3A9F1],ab86712,1:1000,Mouse,"Abcam, Cambridge, UK" NPM1 (mutant),PA1-46356,1:1000,Rabbit,"Invitrogen, Thermo Fischer Scientific, Waltham, MA, USA" SENP3,ab124790,1:500,Rabbit,Abcam ARF,ab185620,1:500,Rabbit,Abcam Histone

(3) Abnormal nucleoli architecture and aggregate formation in nucleophosmin mutated acute myeloid leukaemiaJournal of Cell ScienceMay 15, 2025Martin Grundy, Kellie Lucken, Xiaomeng Xing, Eva L. Simpson, Alice Worker, Ahmed Bayyoomi, Alison J. Beckett, Ian A. Prior, Daniel G. Booth, Claire H. Seedhousemutant which reacts with the C-terminus of mutant NPM1 (rabbit polyclonal, Thermo Fisher Scientific, #PA1-46356), 1:60; nucleolin (rabbit polyclonal, Abcam, Cambridge, UK, #ab22758), 1:100; anti-HP1-α (rabbit monoclonal,

(4) NPM1-Mutated Acute Myeloid Leukemia: Recent Developments and Open QuestionsPathobiology : journal of immunopathology, molecular and cellular biologyJanuary 1, 2024Patel SS.cytoplasmic positivity for mutant NPM1 protein by chromogenic immunohistochemistry (Fast red, antibody clone: PA1-46356 [Thermo Fisher], ×600).

(5) The clinicopathologic significance of NPM1 mutation and ability to detect mutated NPM1 by immunohistochemistry in non-AML myeloid neoplasmsGenes, chromosomes & cancerOctober 1, 2023Kaseb H, Visconte V, Socha DS, Crane GM, Durkin L, Cook JR, Maciejewski JP, Hsi ED, Rogers HJ.Medical Systems Ultra Cell Conditioning CC2 #950–223). The mNPM1 antibody (Thermo Fisher Scientific; PA146356) was diluted 1:2000 and incubated for 16 minutes. Then secondary antibody incubation was done with OmniMap

(6) Cytoplasmic Expression of TP53INP2 Modulated by Demethylase FTO and Mutant NPM1 Promotes Autophagy in Leukemia CellsInternational journal of molecular sciencesJanuary 13, 2023Huang J, Sun M, Tao Y, Ren J, Peng M, Jing Y, Xiao Q, Yang J, Lin C, Lei L, et al.(#LS-C743322, 1:500) was purchased from Lifespan Biosciences (Seattle, WA, USA); Anti-NPM1 mutant Rabbit pAb (#PA1-46356,1:1000) was purchased from Thermo Fisher Scientific; Anti-Histone H3 Rabbit pAb (#ab1791,1:1000) and

(7) Role of immunohistochemistry and flow cytometry in minimal residual disease detection in NPM1-mutated AMLInternational journal of laboratory hematologyApril 1, 2022Aggarwal N, Alston ELJ, Pinkus GS, Weinberg OK.

(8) EAPB0503, an Imidazoquinoxaline Derivative Modulates SENP3/ARF Mediated SUMOylation, and Induces NPM1c Degradation in NPM1 Mutant AMLInternational journal of molecular sciencesMarch 22, 2022Skayneh H, Jishi B, Hleihel R, Hamie M, El Hajj R, Deleuze-Masquefa C, Bonnet PA, El Sabban M, El Hajj H.ex vivo treated primary blasts from AML patients were probed with the following antibodies: NPM1c (PA1-46356, 1:1000, Thermo Fisher Scientific, Waltham, MA, USA), ARF (MA5-14,260, 1:200, Thermo Fisher Scientific,

(9) Mutant NPM1-Regulated FTO-Mediated m(6)A Demethylation Promotes Leukemic Cell Survival via PDGFRB/ERK Signaling AxisFrontiers in oncologyJanuary 1, 2022Xiao Q, Lei L, Ren J, Peng M, Jing Y, Jiang X, Huang J, Tao Y, Lin C, Yang J, et al.internal standard control. Antibodies used for western blotting are as follows: anti-NPM1-mA (1:1000, #PA1-46356) was purchased from Thermo Fisher Scientific; anti-NPM1 (1:1000, #ab52644) was purchased from Abcam;

(10) Biological Effects of BET Inhibition by OTX015 (MK-8628) and JQ1 in NPM1-Mutated (NPM1c) Acute Myeloid Leukemia (AML)BiomedicinesNovember 17, 2021Djamai H, Berrou J, Dupont M, Coudé MM, Delord M, Clappier E, Marceau-Renaut A, Kaci A, Raffoux E, Itzykson R, et al.Courtaboeuf, France) and incubated with the primary antibody overnight at 4 °C: rabbit anti-NPM1m (#PA1-46356, Life Technologies, Courtaboeuf, France), mouse anti-NPM1total (#H00004869-M01), mouse anti-TP53 (#sc-126)

(11) Mutant NPM1-regulated lncRNA HOTAIRM1 promotes leukemia cell autophagy and proliferation by targeting EGR1 and ULK3Journal of experimental & clinical cancer research : CROctober 6, 2021Jing Y, Jiang X, Lei L, Peng M, Ren J, Xiao Q, Tao Y, Tao Y, Huang J, Wang L, et al.°C. The following primary antibodies and respective dilutions were used in this study: anti-NPM1-mA (#PA1–46356, 1:1000; Thermo Fisher Scientific); anti-NPM1-wt (#32–5200, 1:1000; Thermo Fisher Scientific); anti-GAPDH

(12) Comparison of Multiple Clinical Testing Modalities for Assessment of NPM1-Mutant AMLFrontiers in oncologyJanuary 1, 2021Lopez A, Patel S, Geyer JT, Racchumi J, Chadburn A, Simonson P, Ouseph MM, Inghirami G, Mencia-Trinchant N, Guzman ML, et al.formalin fixed paraffin embedded BM core biopsy or clot sections using anti-mutant NPM1 antibody (Thermo Fisher/PA1-46356, Polyclonal, 1:1500 dilution) with ER2 antigen retrieval for 30 mins [H2 (30 mins) on the Leica Bond

(13) Multiparametric in situ imaging of NPM1-mutated acute myeloid leukemia reveals prognostically-relevant features of the marrow microenvironmentModern pathology : an official journal of the United States and Canadian Academy of Pathology, IncJuly 1, 2020Patel SS, Lipschitz M, Pinkus GS, Weirather JL, Pozdnyakova O, Mason EF, Inghirami G, Hasserjian RP, Rodig SJ, Weinberg OK.

(14) miRNA-mRNA Profiling Reveals Prognostic Impact of SMC1A Expression in Acute Myeloid LeukemiaOncology researchMay 29, 2020Gadewal N, Kumar R, Aher S, Gardane A, Gaur T, Varma AK, Khattry N, Hasan SK.according to standard procedures. The mouse monoclonal antibody recognizing specifically NPM1 mutscramble (#PA1-46356; Thermo Fisher Scientific) was used. The monoclonal β-actin antibody (#A5316; Sigma-Aldrich, St. Louis,

(15) Up-regulation of EMT-related gene VCAN by NPM1 mutant-driven TGF-β/cPML signalling promotes leukemia cell invasionJournal of CancerJanuary 1, 2019Yang L, Wang L, Yang Z, Jin H, Zou Q, Zhan Q, Tang Y, Tao Y, Lei L, Jing Y, et al.USA, Cat No: ab200200), rabbit polyclonal mutant NPM1 antibody (1:2000; Thermo Fisher, USA, Cat No: PA1-46356), rabbit polyclonal antibody β-actin (1:1000; Proteintech, USA, Cat No: 20536-1-AP), anti-rabbit secondary

(16) Role of cysteine 288 in nucleophosmin cytoplasmic mutations: sensitization to toxicity induced by arsenic trioxide and bortezomibLeukemiaOctober 1, 2013Huang M, Thomas D, Li MX, Feng W, Chan SM, Majeti R, Mitchell BS.Strep-TagII antibody from Novagen (Madison, WI, USA); anti-mutant nucleophosmin polyclonal antibody (PA1-46356) from Thermo Scientiﬁc (Rockford, IL, USA); rhodamine-conjugated goat anti-mouse secondary antibodies

(17) Mapping the cellular biogeography of human bone marrow niches using single-cell transcriptomics and proteomic imagingCellJanuary 1, 0001"Bandyopadhyay S, Duffy MP, Ahn KJ, Sussman JH, Pang M, Smith D, Duncan G, Zhang I, Huang J, Lin Y, et al."Biosciences,"Cat# 4250094, RRID:AB_3082979" Rabbit polyclonal anti-NPM1 (mutant),Thermo Fisher Scientific,"Cat# PA1-46356, RRID:AB_2267471" Rabbit monoclonal anti-TDT (clone EP266) custom carrier-free,Cell Marque,"Cat# TDT,

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NPM1 (mutant) Antibody

NPM1 (mutant) Antibody from Thermo Fisher Scientific

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NPM1 (mutant) Antibody from Thermo Fisher Scientific

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