Fig 2: Correlation between GPR27 and immune cells from TIMER (https://cistrome.shinyapps.io/timer/). (A) The correlation of the expression of GPR27 with the infiltration of different immune cells. (B) The correlation of the expression of GPR27 and gene markers of immune cells.

Fig 3: Prognostic significance of GPR27 methylation in gastric cancer. The heat map unveils that high expression of GPR27 corresponds to low DNA methylation in gastric cancer (A). A strong correlation between GPR27 expression and DNA methylation is noticed in gastric cancer (B). Hypermethylation of GPR27 is correlated with relatively superior overall survival (C) and disease-free survival (D) in sufferers with gastric cancer.

Fig 4: Survival analysis of GPR27 mRNA in gastric cancer. Low levels of GPR27 are correlated with longer overall time (A) and disease-free survival time (B) based on TCGA dataset. Low levels of GPR27 are related to longer overall time (C) and disease-free survival time (D) based on KM Plotter (http://kmplot.com).

Fig 5: The transcription levels of GPR27 in human cancers. GPR27 mRNA expression in pan-cancer from TIMER (https://cistrome.shinyapps.io/timer/) (A) and Xena Shiny (https://shiny.hiplot.com.cn/ucsc-xena-shiny/) (B) and gastric cancer (C). The expression of GPR27 in different molecular subtypes of cancers via TISIDB (http://cis.hku.hk/TISIDB/index.php) (D).