The GAD65 + GAD67 Polyclonal Antibody from Bioss Inc. is a Rabbit Polyclonal antibody to GAD1, GAD2, Glutamate Decarboxylase 1, and Glutamate Decarboxylase 2. This antibody recognizes Homo Sapiens, Human, and Mouse antigen. The GAD65 + GAD67 Polyclonal Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, Immunohistochemistry - frozen, and Western Blot.
Description
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma aminobutyric acid from L glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin dependent diabetes. This gene may also play a role in the stiff man syndrome