Bioss Inc.'s Liprin alpha 1/PPFIA1 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, Immunohistochemistry - frozen, and Western Blot.
Description
Liprins interact with members of the leukocyte common antigen-related (LAR) family of transmembrane protein tyrosine phosphatases, which are implicated in axon guidance and mammary gland development. Liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR phosphatases. Based on sequence similarities and binding characteristics, liprins are subdivided into Alpha and Beta liprins. Both Alpha and Beta liprins homodimerize via their N-terminal, coiled-coil regions. Liprin Alpha1 is a ubiquitously expressed protein that interacts with the tumor suppressor ING4 to regulate cell migration and possibly prevent metastasis. The interaction between LAR and Liprin Alpha1 can be weakened by treatment of Liprin ? with calf intestinal phosphatase