The BDP/ARID3B Polyclonal Antibody, Cy5 Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to ARID3B. This antibody recognizes Homo Sapiens, and Human antigen. The BDP/ARID3B Polyclonal Antibody, Cy5 Conjugated has been shown to work in the following applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, Immunohistochemistry - frozen, and Western Blot.
Description
ARID3B represents a member of a unique family of DNA-binding proteins that have roles in cell lineage gene regulation, cell cycle control, embryonic patterning and transcriptional regulation. ARID3B localizes to the nucleus and contains an AT-rich interactive domain (ARID) which has DNA-binding capabilities. Functioning as a transcription factor, ARID3B associates in a heterodimer with the related protein ARID3A and is believed to play an important role in neural crest survival during embryogenesis. In addition, ARID3B may participate in malignant transformation and neuroblastoma growth, suggesting a possible use of ARID3B as a tumor marker for neuroblastoma