The LC3 Polyclonal Antibody, HRP Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to MAP1LC3A, and MAP1LC3B. This antibody recognizes Mouse antigen. The LC3 Polyclonal Antibody, HRP Conjugated has been shown to work in the following applications: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway