Abbexa Ltd's Mouse TUG Antibody is a Mouse monoclonal antibody. The Mouse TUG Antibody was generated using ASPSCR1, and ASPSCR1 tether for SLC2A4, UBX domain containing as the antigen. It reacts with Mouse. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, and Western Blot.
Description
The TUG protein contains a UBX domain, for GLUT4.In truncated form, TUG acts in a dominant-negative manner to inhibit insulin-stimulated GLUT4 redistribution in Chinese hamster ovary cells and 3T3-L1 adipocytes.Full-length TUG forms a complex specifically with GLUT4.In 3T3-L1 adipocytes, this complex is present in unstimulated cells and is largely disassembled by insulin.Endogenous TUG is localized with the insulin-mobilizable pool of GLUT4 in unstimulated 3T3-L1 adipocytes, and is not mobilized to the plasma membrane by insulin