Calmodulin Antibody 4830S from Cell Signaling Technology

Product Specs
ItemCalmodulin Antibody
CompanyCell Signaling Technology
Price $306.00 Inquire
Catalog Number4830S
Quantity100 µl
ApplicationsW
ReactivityM, R
TargetCalmodulin
Molecular Weight17
HostRabbit
NCBI Gene AliasesCALML2, CAM2, CAM3, CAMB, CAMC, CAMI, CAMIII, CPVT4, DD132, LQT14, PHKD, PHKD1, caM
NCBI Full Gene Namecalmodulin 1
ClonalityPolyclonal
Research AreaCa, cAMP and Lipid Signaling

Questions and Answers

What species does this calmodulin antibody work with in experiments?

The Calmodulin Antibody detects endogenous levels of total calmodulin protein in mouse and rat samples.

Can this antibody be used for immunocytochemistry applications?

Yes, the Calmodulin Antibody has been utilized in immunocytochemistry, as evidenced by its use in studies examining the trafficking of KCNQ channels in neurons, where it played a role in visualizing calmodulin interactions.

How does calmodulin interact with KCNQ channels, and what is the significance of this interaction?

Calmodulin is crucial for the enrichment of KCNQ channels at the axonal surface, as it regulates their trafficking from the endoplasmic reticulum to the axon. Disruption of calmodulin binding impairs this process, which is essential for controlling neuronal excitability, as shown in studies involving hippocampal neurons.

Are there any specific experimental conditions or modifications noted in the literature for using this antibody effectively?

In various studies, the Calmodulin Antibody has been used at a dilution of 1:1000 for Western blotting and immunoprecipitation, indicating that proper dilution is important for optimal detection of calmodulin in protein assays.

Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Visualizing insecticide control of insect TRP channel function and assemblyNature CommunicationsDecember 14, 2025Justin G. Fedor, Ramani Kandasamy, Cheon-Gyu Park, Yang Suo, Martin Weisel, Nancy B. Rankl, Alexandre Nesterov, Seok-Yong Lee20 mM Tris-HCl (pH 8.0), 150 mM NaCl, 0.1% Tween-20 at 4 °C: rabbit anti-CaM (1:1000) Cell Signaling 4830S (lot: 4); mouse anti-His (1:3000, Invitrogen MA1-21315). After extensive washing, blots were incubated

(2) CTRP9 engages AdipoR1 and promotes T cell glycolysis and immunityEMBO ReportsNovember 17, 2025Kunming Li, Jiansong Zhang, Kang Li, Haokai Chen, Wenhai Deng, Wenzhuo Rao, Ming Geng, Yuying Zheng, Xiumei Wei, Jialong YangCell Signaling Technology), p-AMPKα antibody (Thr172, Catalog #2535, Cell Signaling Technology), CaM (Catalog #4830, Cell Signaling Technology) or CaMKKβ (Catalog #16810, Cell Signaling Technology) on ice for 30 min

(3) A lightweight neural attention-based model for service chatbotsSci RepAugust 13, 2025Sinarwati Mohamad Suhaili, Mohamad Nazim Jambli\usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\Delta$$\end{document} #M3 Additive,4830,– M4 Additive + Scaled Function,3480,– 28 % Average epoch time on the CST dataset.

(4) Trifolin inhibits the calcium-driven contraction pathway in vascular smooth muscleFrontiers in PharmacologyMay 30, 2025Renfeng Li, Jinkong Wu, Meizhu Wu, Farman Ali, Yanyan Yang, Hong Chen, Zhi Guo, Dawei Lian, Aling Shen, Jun Peng28411-1-AP) were purchased from ProteinTech (Rosemont, IL, United States). Antibody against CaM (Cat. No. 4830s) was purchased from Cell Signaling Technology (Danvers, MA, United States). Antibody against MLC2 (Cat.

(5) Neurogranin regulates calcium-dependent cardiac hypertrophyExperimental and Molecular PathologyAugust 1, 2022Ashton N. Jorgensen, Chowdhury S. Abdullah, Md. Shenuarin Bhuiyan, Megan Watt, Paari Dominic, Gopi K. Kolluru, Christopher G. Kevil, Hyung W. Nam#AB9080 (Millipore, Billerica, MA), Periostin #PA5–34641 (Invitrogen, Carlsbad, CA, USA), Calmodulin #4830S, Phospho-CaMKII (T286) #12716S, and CaMKII (pan) #4436S (Cell Signaling, Danvers, MA), and GAPDH #SC-32233

(6) Puerarin alleviates cisplatin‑induced acute renal damage and upregulates microRNA‑31‑related signalingExperimental and Therapeutic MedicineJuly 29, 2020Zhen Wu, Chunfeng Li, Qiang Li, Jing Li, Xin LuCell Signaling Technology, Inc.), Numb (cat. no. 2761s; 1:1,000; Cell Signaling Technology, Inc.), Notch1 (cat. no. 4830s; 1:1,000; Cell Signaling Technology, Inc.) and β-actin (cat. no. 4970s; 1:1,000; Cell Signaling Technology,

(7) Calcium-binding proteins are altered in the cerebellum in schizophreniaPLOS ONEJuly 8, 2020Francisco Vidal-Domènech et al.immunoblotted with rabbit polyclonal antibody against VPP1 (1:500; ab103680, Abcam) and calmodulin (1:1000; 4830, Cell Signalling Technologies), and monoclonal antibodies against parvalbumin (1:1000; MAB1572, Millipore-Chemicon)

(8) Ca(2+)-Calcineurin Axis-Controlled NFAT Nuclear Translocation Is Crucial for Optimal T Cell Immunity in an Early VertebrateJournal of immunology (Baltimore, Md. : 1950)February 1, 2020Wei X, Li H, Zhang Y, Li C, Li K, Ai K, Yang J.1:100 diluted rabbit–anti phospho-IP3R (8548; Cell Signaling Technology), rabbit-anti calmodulin (4830; Cell Signaling Technology) or mouse-anti NFAT1 (sc-7296; Santa Cruz Biotechnology) as primary Abs at

(9) A Temporal Examination of Cytoplasmic Ca^{2 +} Levels, Sarcoplasmic Reticulum Ca^{2 +} Levels, and Ca^{2 +} -Handling-Related Proteins in Different Skeletal Muscles of Hibernating Daurian Ground SquirrelsFrontiers in physiologyJanuary 1, 2020Wang Z, Zhang J, Ma XF, Chang H, Peng X, Xu SH, Wang HP, Gao YF.Kingdom" CaMK2,"1:500, 3357S, CST, United States" P-CaMK2,"1:1000, 12716S, CST, United States" CaM,"1:1000, 4830S, CST, United States" CSQ1,"1:10000, ab191564, Abcam, United Kingdom" Primary and secondary antibodies

(10) Potential roles of neuronal nitric oxide synthase and the PTEN-induced kinase 1 (PINK1)/Parkin pathway for mitochondrial protein degradation in disuse-induced soleus muscle atrophy in adult ratsPloS oneJanuary 1, 2020Uda M, Yoshihara T, Ichinoseki-Sekine N, Baba T, Yoshioka T.polyclonal antibody (ab16650, Abcam, diluted 1:4000), rabbit anti-calmodulin polyclonal antibody (#4830, Cell Signaling Technology, diluted 1:1000), rabbit antiHSP90 polyclonal antibody (ab13495, Abcam, diluted

(11) Priority Strategy of Intracellular Ca(2+) Homeostasis in Skeletal Muscle Fibers During the Multiple Stresses of HibernationCellsDecember 22, 2019Zhang J, Li X, Ismail F, Xu S, Wang Z, Peng X, Yang C, Chang H, Wang H, Gao Y.4219S, USA), MCU (1:1000, CST, 14997S, USA), MICU1 (1:750, CST, 12524S, USA), and CALM (1:1000, CST, 4830S, USA) antibodies in TBST containing 0.1% BSA. The membranes where then washed three times with TBST

(12) Amplification of Drosophila Olfactory Responses by a DEG/ENaC ChannelNeuronDecember 1, 2019Renny Ng, Secilia S. Salem, Shiuan-Tze Wu, Meilin Wu, Hui-Hao Lin, Andrew K. Shepherd, William J. Joiner, Jing W. Wang, Chih-Ying Su(LIfeTechnologies) gels for electrophoresis and Western blotting with polyclonal anti-calmodulin antibody (#4830, Cell Signaling). QUANTIFICATION AND STATISTICAL ANALYSIS All data were analyzed using Excel or MATLAB.

(13) Contribution of Coiled-Coil Assembly to Ca²⁺/Calmodulin-Dependent Inactivation of TRPC6 Channel and its Impacts on FSGS-Associated PhenotypesJournal of the American Society of NephrologySeptember 1, 2019Onur K. Polat et al.[TBST] with 3% BSA) for 1 hour at RT and was incubated overnight at 4°C with rabbit anti-CaM (cat. no. 4830, 1:1000 dilution with blocking buffer; Cell Signaling Technologies). After treatment with the primary

(14) Reduced axonal surface expression and phosphoinositide sensitivity in K_v7 channels disrupts their function to inhibit neuronal excitability in Kcnq2 epileptic encephalopathyNeurobiology of diseaseOctober 1, 2018Kim EC, Zhang J, Pang W, Wang S, Lee KY, Cavaretta JP, Walters J, Procko E, Tsai NP, Chung HJ.(Alomone, APC-051) anti-HA (Covance, MMS-101P, Cell Signaling, 3724 & 2369), anti-CaM (Cell Signaling, 4830), anti-GAPDH (Cell Signaling, 2118), HRP-conjugated secondary antibodies (The Jackson Laboratory, 715-005-151,

(15) Cobl-like promotes actin filament formation and dendritic branching using only a single WH2 domainThe Journal of cell biologyJanuary 2, 2018Izadi M, Schlobinski D, Lahr M, Schwintzer L, Qualmann B, Kessels MM.(MMS-150P and SMI-32P). Polyclonal rabbit anti-CaM antibodies were from Cell Signaling Technology (4830). Alexa Fluor 488– and Alexa Fluor 647–conjugated phalloidin and MitoTracker Deep Red 633 were from

(16) Lipophilic statins limit cancer cell growth and survival, via involvement of Akt signalingPloS oneJanuary 1, 2018Beckwitt CH, Shiraha K, Wells A.

(17) Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cellsScientific reportsAugust 14, 2017Abdullah MI, Abed MN, Richardson A.

(18) Dietary geranylgeraniol can limit the activity of pitavastatin as a potential treatment for drug-resistant ovarian cancerScientific reportsJuly 14, 2017de Wolf E, Abdullah MI, Jones SM, Menezes K, Moss DM, Drijfhout FP, Hart SR, Hoskins C, Stronach EA, Richardson A.

(19) A Combination of Flaxseed Oil and Astaxanthin Improves Hepatic Lipid Accumulation and Reduces Oxidative Stress in High Fat-Diet Fed RatsNutrientsMarch 13, 2017Xu J, Rong S, Gao H, Chen C, Yang W, Deng Q, Huang Q, Xiao L, Huang F.

(20) Endothelial CaMKII as a regulator of eNOS activity and NO-mediated vasoreactivityPloS oneJanuary 1, 2017Murthy S, Koval OM, Ramiro Diaz JM, Kumar S, Nuno D, Scott JA, Allamargot C, Zhu LJ, Broadhurst K, Santhana V, et al.Covance. Antibodies directed to eNOS (#9586) (used for immunoprecipitation), GAPDH (#2178), calmodulin (#4830), phosphoThr-287 CaMKII (#12716), phosphoSer-1179 in bovine eNOS (#9571), phosphoThr-497 in bovine eNOS

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Calmodulin Antibody

Calmodulin Antibody from Cell Signaling Technology

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Cell Signaling Technology

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Calmodulin Antibody from Cell Signaling Technology

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