Phospho-IRS-1 (Ser612) (C15H5) Rabbit mAb 3203S from Cell Signaling Technology

Product Specs
ItemPhospho-IRS-1 (Ser612) (C15H5) Rabbit mAb
CompanyCell Signaling Technology
Price $397.00 Inquire
Catalog Number3203S
TargetIRS-1 (Ser616) phosphate
ModificationsIRS-1 (Ser616) phosphate
HostRabbit
NCBI Gene AliasesHIRS-1
ClonalityMonoclonal
NCBI Full Gene Nameinsulin receptor substrate 1
ApplicationsWestern Blot (WB)
ReactivityHu, Ms, Rt
IsotypeIgG
CloneC15H5
Molecular Weight180
Research AreaMetabolism
Quantity100 µl

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) A genome-wide, CRISPR-based screen reveals new requirements for translation initiation and ubiquitination in driving adipogenic fate changeGenes & DevelopmentOctober 1, 2025Rachel E. Turn, Keren I. Hilgendorf, Carl T. Johnson, Kyuho Han, Mohammad Ovais Aziz-Zanjani, Samuel Swails Bollinger, Pablo Domizi, Ran Cheng, Atefeh Rabiee, Yingdi Zhu, et al.680 and 800 nm. The antibodies used were as follows: pIRS1 (1:1000; Cell Signaling Technology 2381, 3203, and 5610), pAKT (1:1000; Cell Signaling Technology 4051), and Tubulin (1:5000; Sigma- 9026). Immunofluorescence

(2) AMPK-Targeting Effects of (-)-Epicatechin Gallate from Hibiscus sabdariffa Linne Leaves on Dual Modulation of Hepatic Lipid Accumulation and Glycogen Synthesis in an In Vitro Oleic Acid ModelInt J Mol SciAugust 6, 2025Hui-Hsuan Lin, Pei-Tzu Wu, Yu-Hsuan Liang, Ming-Shih Lee, Jing-Hsien ChenSanta Cruz Biotechnology (Santa Cruz, CA, USA), p-AMPK (2535), p-IRS-1-Ser307 (2381), and p-IRS-1-Tyr612 (3203) from Cell Signaling Technology (Danvers, MA, USA), and anti-β-actin (A5441), obtained from Sigma-Aldrich

(3) PTEN protein phosphatase activity regulates metastasis by targeting PKCδiScienceJune 20, 2025Yanlin Yu, Ming Zhao, Rand Gabriel M. Buenaventura, Glenn Merlinoanti-p-PKC S643 (Cat#9376), anti-p-PKCδ T311 (Cat# 2055), anti-IRS1 (Cat#3407) and anti-p-IRS1 S612 (Cat#3203) antibodies were obtained from Cell Signaling (Danvers, MA, USA). anti-β-actin (Cat#58673), and anti-add3

(4) AGDMP1 alleviates insulin resistance by modulating heat shock protein 60-mediated IRS-1/AKT/GLUT4 pathway and adipose inflammation: A potential therapeutic peptide for gestational diabetes mellitusFASEB JJanuary 31, 2025Shanshan Wang, Yuting Zhang, Shiman Hu, Xueqi Bai, Jiamin Zhu, Runrun Hao, Yan Cao, Zhonghua Shiantibodies at 4°C overnight. The primary antibodies were as follows: phospho‐IRS‐1 (Ser612) rabbit mAb (3203, CST, USA), IRS‐1 rabbit mAb (3407, CST, USA), phospho‐Akt (Ser473) rabbit mAb (4060, CST, USA), Akt

(5) AGDMP1 alleviates insulin resistance by modulating heat shock protein 60‐mediated IRS‐1/AKT/GLUT4 pathway and adipose inflammation: A potential therapeutic peptide for gestational diabetes mellitusFASEB JJanuary 24, 2025Shanshan Wang, Yuting Zhang, Shiman Hu, Xueqi Bai, Jiamin Zhu, Runrun Hao, Yan Cao, Zhonghua Shiantibodies at 4°C overnight. The primary antibodies were as follows: phospho‐IRS‐1 (Ser612) rabbit mAb (3203, CST, USA), IRS‐1 rabbit mAb (3407, CST, USA), phospho‐Akt (Ser473) rabbit mAb (4060, CST, USA), Akt

(6) KIC (ketoisocaproic acid) and leucine have divergent effects on tissue insulin signaling but not on whole-body insulin sensitivity in ratsPLOS ONEAugust 20, 2024Gagandeep Mann, Stephen Mora, Olasunkanmi A. John Adegoke(Thr389, #9234), S6 (Ser235/6, #4858), Akt (Ser473, #4060), BCKD-E1α (Ser293, #40368), IRS-1 (Ser612, #3203) and total BCKD‐E1α (#90198), as well as horseradish peroxidase (HRP)‐conjugated anti‐rabbit (#7074)

(7) Metformin reduces basal subpopulation and attenuates mammary epithelial cell stemness in FVB/N miceFrontiers in Cell and Developmental BiologyJuly 11, 2024Minghui Shan, Qiong Cheng, Amanda B. Parris, Lingfei Kong, Xiaohe Yang, Yujie ShimTOR (2983), p-STAT3 (Tyr705) (9145), S6 (2217), p-S6 (Thr389) (9205), IRS1 (3407), p-IRS1 (Ser612) (3203) and β-catenin (8480) primary antibodies were sourced from Cell Signaling Technologies. Primary antibodies

(8) BMSC‑derived exosome‑mediated miR‑25‑3p delivery protects against myocardial ischemia/reperfusion injury by constraining M1‑like macrophage polarizationMolecular Medicine ReportsJune 18, 2024Jingxia Du, Yibo Dong, Jingjing Song, Hanqi Shui, Chengyao Xiao, Yue Hu, Shiyao Zhou, Shanshan WangLtd.), CD63 (1:1,000; cat. no. D111314-0100100; Sangon Biotech Co., Ltd.), JAK2 (1:1,000; cat. no. 3203; Cell Signaling Technology, Inc.), phosphorylated (p-)JAK2 (1:1,000; cat. no. 37745; Cell Signaling

(9) Defective Visceral Adipose Tissue Adaptation in Gestational Diabetes MellitusThe Journal of Clinical Endocrinology & MetabolismApril 19, 2024Colm J McElwain, Samprikta Manna, Andrea Musumeci, Isaac Sylvester, Chloé Rouchon, Anne Marie O'Callaghan, Mustafa Abdalla Bakhit Ebad, Fergus P McCarthy, Cathal M McCarthyphospho-IRS1(ser323) 1:1000 (Cell Signaling #5610, RRID:AB_10695244); phospho-IRS1(ser616) 1:1000 (Cell Signaling #3203, RRID:AB_1031167); PDK1 1:1000 (Cell Signaling #3062, RRID:AB_2236832); PI3K 1:1000 (Cell Signaling

(10) Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female miceScientific ReportsJanuary 3, 2024Adriana C. Norris, Eugenia M. Yazlovitskaya, Lin Zhu, Bailey S. Rose, Jody C. May, Katherine N. Gibson-Corley, John A. McLean, John M. Stafford, Todd R. Grahamphospho-IGF-IRβY1135/1136/IRβY1150/1151(#3024, Cell Signaling), IRβ (#3025, Cell Signaling), phospho-IRS-1S612 (#3203, Cell Signaling), IRS-1 (#3407, Cell Signaling), phospho-AktT308/S473 (#13038/#4060, Cell Signaling),

(11) Elevated BCAA catabolism reverses the effect of branched-chain ketoacids on glucose transport in mTORC1-dependent manner in L6 myotubesJournal of nutritional scienceJanuary 1, 2024Mann G, Adegoke OAJ.1:1000), ph-BCKDH-E1α (Ser293, #40368, 1:1000), ph-ACC (Ser 79, #3661, 1:1000) and ph-IRS-1 (Ser612, #3203, 1:1000), as well as horseradish peroxidase (HRP)-conjugated anti-rabbit (#7074, 1:10000) and anti-mouse

(12) Jianpi Qinghua Fomula alleviates insulin resistance via restraining of MAPK pathway to suppress inflammation of the small intestine in DIO miceBMC Complementary Medicine and TherapiesDecember 1, 2022Yahua Liu, Xu Han, Mengjie Cai, Shenyi Jin, Zihui Yan, Hao Lu, Qingguang Chen(4695S,1:1000), PI3K (4249S,1:1000), Akt(3063S,1:1000), p-Akt (4060S, 1:1000), IRS1 (2382S,1:10 00), p-IRS1 (3203S,1:1000), p-IRS2 (4502S,1:1000) and secondary antibody were purchased from Cell Signaling Technology

(13) Activation of the insulin receptor by an insulin mimetic peptideNature communicationsSeptember 23, 2022Park J, Li J, Mayer JP, Ball KA, Wu J, Hall C, Accili D, Stowell MHB, Bai XC, Choi E.anti-pERK1/2 (WB, 1:000; 197G2, Cat. #4377), anti-IRS1-pS616 (WB, 1:1000; C15H5, Cell Signaling, Cat. #3203); anti-IRS1 (WB, 1:1000; A301-158A, Bethyl Laboratory); anti-IR (WB, 1:500, CT-3, Santa Cruz; labeled

(14) AICAR Protects Vascular Endothelial Cells from Oxidative Injury Induced by the Long-Term Palmitate ExcessInternational Journal of Molecular SciencesDecember 25, 2021Mikhail V. Samsonov et al.for Western blots. For Western blotting, the following antibodies were used: phospho-IRS1 (Tyr612) (# 3203), phospho-Akt (Thr308) (# 9275), phospho-Akt (Ser473) (# 4060), total Akt (# 4691), phospho-IKK (# 2697),

(15) Role of hepatic PKCβ in nutritional regulation of hepatic glycogen synthesisJCI insightOctober 8, 2021Shu Y, Hassan F, Ostrowski MC, Mehta KD.GS (catalog 3893), P-GSSer641 (catalog 94905), P-IRS-1Ser307 (catalog 2381), P-IRS-1Ser612 (catalog 3203), P-TSC2Ser939 (catalog 3615), TSC2 (catalog 3612), p-mTORSer2449 (catalog 5536), mTOR (catalog 2983),

(16) White Adipose Tissue Autophagy and Adipose-Liver Crosstalk Exacerbate Nonalcoholic Fatty Liver Disease in MiceCellular and Molecular Gastroenterology and HepatologyJuly 22, 2021Sadatsugu Sakane, Hayato Hikita, Kumiko Shirai, Yuta Myojin, Youichi Sasaki, Shinnosuke Kudo, Kenji Fukumoto, Naoki Mizutani, Yuki Tahata, Yuki Makino, et al.Rabbit Ab,Cell Signaling Technology,#9661 p-IRS-1 (S612) (C15H5) Rabbit mAb,Cell Signaling Technology,#3203 IRS-1 (D23G12) Rabbit mAb,Cell Signaling Technology,#3407 IRS-2 Rabbit mAb,Cell Signaling Technology,#4502 p-PDK1

(17) Exendin-4 gene modification and microscaffold encapsulation promote self-persistence and antidiabetic activity of MSCsScience advancesJuly 1, 2021Zhang Y, Gao S, Liang K, Wu Z, Yan X, Liu W, Li J, Wu B, Du Y.(2535S, Cell Signaling Technology), anti-AMPK (5831S, Cell Signaling Technology), anti–phospho–IRS-1 (3203S, Cell Signaling Technology), anti–IRS-1 (3407S, Cell Signaling Technology), and anti–β-actin (4970S,

(18) Hepatocyte-specific PKCβ deficiency protects against high-fat diet-induced nonalcoholic hepatic steatosisMolecular metabolismFebruary 1, 2021Shu Y, Hassan F, Coppola V, Baskin KK, Han X, Mehta NK, Ostrowski MC, Mehta KD.receptor beta (#3025), P-insulin receptor/IGF1R beta (#3021), P-IRS-1Ser307 (#2381), P-IRS-1Ser612 (#3203), P-IRS1Ser318 (#5610), IRS-2 (#4502), P-mTORSer2448 (#5536), P-mTORSer2481 (#2974), mTOR (#2983), rictor

(19) Enhanced skeletal muscle insulin sensitivity after acute resistance-type exercise is upregulated by rapamycin-sensitive mTOR complex 1 inhibitionScientific ReportsDecember 1, 2020Kohei Kido, Kohei Sase, Takumi Yokokawa, Satoshi Fujita(Cat#2708), p-IRS-1-Ser1101(rat: Ser1100) (Cat#2385), Ser636/639 (rat: Ser632/635) (Cat#2388) and Ser612 (Cat#3203), total IRS-1 (Cat#3194), p-Akt-Thr308 (Cat#13038) and Thr473 (Cat#9271), and total Akt (Cat#4691) (Cell Signaling Technology

(20) Runx2+ Niche Cells Maintain Incisor Mesenchymal Tissue Homeostasis through IGF SignalingCell reportsAugust 11, 2020Chen S, Jing J, Yuan Y, Feng J, Han X, Wen Q, Ho TV, Lee C, Chai Y.Receptor,Abcam,Cat# ab39398; RRID:AB_731544 Rabbit anti-Phospho-IRS-1 (Ser612),Cell Signaling Technology,Cat# 3203; RRID:AB_1031167 Rabbit anti-Phospho-Akt (Ser473),Cell Signaling Technology,Cat# 4060; RRID:AB_2315049 Rabbit

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Phospho-IRS-1 (Ser612) (C15H5) Rabbit mAb

Phospho-IRS-1 (Ser612) (C15H5) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

Citations (34)

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Phospho-IRS-1 (Ser612) (C15H5) Rabbit mAb from Cell Signaling Technology

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