RelB (C1E4) Rabbit mAb 4922S from Cell Signaling Technology

Product Specs
ItemRelB (C1E4) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number4922S
Quantity100 µl
ApplicationsW, IP, C&R
ReactivityH, M, R, Mk
TargetRelB
HostRabbit
NCBI Gene AliasesI-REL, IMD53, IREL, REL-B
ClonalityMonoclonal
NCBI Full Gene NameRELB proto-oncogene, NF-kB subunit
Research AreaImmunology and Inflammation
IsotypeIgG
CloneC1E4
Molecular Weight70

Questions and Answers

What applications has the RelB (C1E4) Rabbit mAb been shown to be effective in?

The RelB (C1E4) Rabbit mAb has been shown to work effectively in Western Blotting (WB) and Immunoprecipitation (IP) applications, as evidenced by its use in various studies including those investigating NF-κB signaling pathways.

Can this antibody be used for studies involving cancer research?

Yes, the RelB antibody has been utilized in cancer research, particularly in studies examining its role in tumorigenesis. For instance, it has been shown to promote the expression of mesenchymal genes in gliomas, indicating its involvement in cancer stem cell regulation and tumor growth (Lee et al., 2013).

Is the RelB antibody reactive with human samples?

Yes, the RelB (C1E4) Rabbit mAb is reactive with human samples, as well as with mouse, rat, and non-human primate samples. This broad reactivity makes it suitable for various experimental models in immunology and inflammation research.

How has the RelB antibody been utilized in studies related to immune responses?

The RelB antibody has been used in studies to investigate its role in immune responses, such as in the context of dendritic cell function and intestinal inflammation. Research has shown that non-canonical NF-κB signaling involving RelB can exacerbate intestinal pathologies by affecting dendritic cell activity (Deka et al., 2024).

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) MK2/p38/p53 Suppress Basal IL-1β and Non-Canonical NF-κB Signaling in MacrophagesInt J Mol SciApril 2, 2026Sarah M. Herr, Diana Stalkopf, Sofie Padaszus, Lukas A. Herbst, Anneke Dörrie, Rainer Niedenthal, Natalia Ronkina, Tatiana Yakovleva, Alexey Kotlyarov, Matthias GaestelNF-κB2 p100/p52 (4882, CST, Cambridge, UK), NF-κB p65 (L8F6) (6956, CST, Cambridge, UK), RelB (C1E4) (4922, CST, Cambridge, UK), p53 (1C12) (2524, CST, Cambridge, UK), c-Rel (D4Y6M) (12707, CST, Cambridge, UK),

(2) Mucosal vaccination with long-form TSLP induces migratory cDC1-mediated adaptive immunity against SARS-CoV-2 infectionJournal of VirologySeptember 23, 2025Jing Hu, Housheng Zheng, Wei Ran, Xuefei Wang, Chenghui Liao, Jian Zhou, Liang Ye(Cell Signaling, 4994), p100 (Cell Signaling, 4882), phospho-p100 (Cell Signaling, 4810), RelB (Cell Signaling, 4922), STAT5 (Proteintech, 13179-1-AP), phospho-STAT5 (Cell Signaling Technology, 9351), and β-actin (Abcam,

(3) Dual-edged mechanisms of α-tomatine in hepatocellular carcinoma by suppression of Wnt/β-catenin signaling versus RelB-Driven resistance in tumor therapyFrontiers in PharmacologySeptember 22, 2025Tianzhen Wang, Chenyue Xu, Yanling Yuan, Bianhong Zhanganti-β-actin (1:5,000, Cat a1978, Sigma), anti-tubulin (1:5000, Cat T8203, Sigma), anti-RelB (1:1000, Cat 4922, CST), anti-p100 (1:1000, Cat 05–361, Sigma), anti-IKK1 (1:1000, Cat 2682, CST), β-catenin (1:2000,

(4) NLRP3 inflammasome impairs fracture repair in Rheumatoid arthritis through RhoA/Rac1-IL1β axis-mediated suppression of osteoblast differentiationJournal of orthopaedic translationSeptember 1, 2025Miao F, Cai H, Chen Y, Yan Z, Jin R, Dai Y, Li L, Wang H, Xu Y, Sun W.Cat#AF3028), NF-κB1 (CST, Cat#12540S), NF-κB2 (CST, Cat#4882S), RelA (CST, Cat#8242S), RelB (CST, Cat#4922S), and β-Actin (Santa Cruz, Cat#sc-47778) at 4 °C overnight. The following day, the membranes were washed

(5) MT1H inhibits the growth of gastric cancer by regulating SLC6A19/TTC39B/ADM2 and activating p53-dependent autophagySci RepMarch 18, 2025Yamin Xing, Guangyuan Li, Ganggang Li, Jixuan Xu, Ting Zhang, Mengxue Li, Chunxiao Gao, Miaoran Fu, Pengyuan Zheng, Xiufeng ChuHercules, CA, USA). Antibodies and reagents For immunoblotting, LSD1 (2184), NF-κB p65 (8242T), RelB (4922T), Erk1/2 (9102), p-Erk1/2 (Thr202/Tyr204) (C4370S), and the Human Reactive Cell Death and Autophagy Antibody Sampler Kit

(6) Inhibition of GSK3β is synthetic lethal with FHIT loss in lung cancer by blocking homologous recombination repairExperimental & molecular medicineFebruary 1, 2025Tao S, Pu Y, Yang EJ, Ren G, Shi C, Chen LJ, Chen L, Shim JS.Invitrogen), ATR (13934 s, CST). pho-ATR (s428) (2853 s, CST), Snail (3879, CST), Slug (9585, CST), RELB (4922 s, CST), GAPDH (sc-3650620, Santa Cruz), goat anti-mouse IgG (H + L) peroxidase conjugated (31430, Thermo Scientific

(7) Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammationCellular & molecular immunologyJanuary 1, 2025Meng X, Asadi-Asadabad S, Cao S, Song R, Lin Z, Safhi M, Qin Y, Tcheumi Tactoum E, Taudte V, Ekici A, et al.TRAF3 (1:1000, 4729T; Cell Signaling), NF-κB2 p100/p52 (1:1000, 4882T; Cell Signaling), RelB (1:1000, 4922T; Cell Signaling), pSmad3 (1:500, 9520T; Cell Signaling), Histone H3 (1:1000, EPR17785; Cell Signaling)

(8) DAB2IP loss in luminal a breast cancer leads to NF-κB–associated aggressive oncogenic phenotypesJCI InsightDecember 6, 2024Angana Mukherjee, Rasha T. Kakati, Sarah Van Alsten, Tyler Laws, Aaron L. Ebbs, Daniel P. Hollern, Philip M. Spanheimer, Katherine A. Hoadley, Melissa A. Troester, Jeremy M. Simon, et al.immunoprecipitation, 25 μg DNA was incubated with primary antibodies (anti-p65, CST, 8242; anti-RelB, CST, 4922; anti-NFKB2, CST, 4882) for 1 hour and incubated with blocked protein G beads for 40 minutes at 4°C.

(9) Non-canonical NF-κB signaling limits the tolerogenic β-catenin-Raldh2 axis in gut dendritic cells to exacerbate intestinal pathologiesThe EMBO journalSeptember 1, 2024Deka A, Kumar N, Basu S, Chawla M, Bhattacharya N, Ali SA, Bhawna, Madan U, Kumar S, Das B, et al.polyclonal,Santa Cruz Biotechnology,sc-372; AB_632037 Anti-RelB rabbit polyclonal,Cell Signaling Technology,4922S; AB_2179173 Anti-mouse p52/p100 rabbit polyclonal,Generated in the Lab,Mouse p52/p100 sequence used:

(10) TBK1 and IKKε protect target cells from IFNγ-mediated T cell killing via an inflammatory apoptotic mechanismbioRxiv : the preprint server for biologyAugust 8, 2024Sun ND, Carr AR, Krogman EN, Chawla Y, Zhong J, Guttormson MC, Chan M, Hsu MA, Dong H, Bogunovic D, et al.NFκB p105/p50 (Cell Signaling, 12540S), NFκB p100/p52 (Cell Signaling, 52583S), RelB (Cell Signaling, 4922S), phospho-IκBα (Ser32/36) (Cell Signaling, 9246S), IκBα (Cell Signaling, 4812S), phospho-IKKα/β (Ser176/180)

(11) Sustained activation of NF-κB through constitutively active IKKβ leads to senescence bypass in murine dermal fibroblastsCell cycle (Georgetown, Tex.)February 1, 2024Harada M, Su-Harada K, Kimura T, Ono K, Ashida N.phospho-histone H2A.X (Ser139) (#9718), and acetyl-p53 (Lys379) (#2570), CDK6 (#3136), Ezh2 (#5246), RelB (#4922), all purchased from Cell Signaling Technology, and p21 (#sc-6246), which was purchased from Santa Cruz.

(12) The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistanceNature geneticsJanuary 1, 2024Caswell DR, Gui P, Mayekar MK, Law EK, Pich O, Bailey C, Boumelha J, Kerr DL, Blakely CM, Manabe T, et al.(S473, 4060), anti-phospho-ERK (T202, Y204; 4370 or 9106), anti-ERK (9102), anti-RELA (8242), anti-RELB (4922), anti-HSP90 (4874), anti-TUBB (2146) and anti-histone H3 (9715) were purchased from Cell Signaling Technology

(13) Immunomodulatory Effects of Primed Tonsil-Derived Mesenchymal Stem Cells on Atopic Dermatitis via B Cell RegulationCellsDecember 30, 2023Kim DK, Lee HJ, Lee IH, Lee JJ.canonical NF-κB pathway, and phospho-p100 (#4810, Cell signaling), p52 (#4882, Cell signaling), and RELB (#4922, Cell signaling) of the non-canonical NF-κB pathway (Cell signaling Technology, Danvers, MA, USA), an-ti-CD40

(14) Characterization of target gene regulation by the two Epstein-Barr virus oncogene LMP1 domains essential for B-cell transformationmBioNovember 27, 2023Bidisha Mitra, Nina Rose Beri, Rui Guo, Eric M. Burton, Laura A. Murray-Nerger, Benjamin E. Gewurzp105/50 (#3035, rabbit mAb), RelA (#8242, rabbit mAb), phospho-RelA (Ser536) (3033, rabbit mAb), RelB (#4922, rabbit mAb), cRel (#4727, rabbit mAb), IκBα (#9247, mouse mAb), IRF4 (#4964, rabbit mAb), BATF (#8638,

(15) The effect of an exopolysaccharide probiotic molecule from Bacillus subtilis on breast cancer cellsFrontiers in OncologyNovember 23, 2023Mai R. Nguyen, Emily Ma, Debra Wyatt, Katherine L. Knight, Clodia Osipo(Ser536, # 3033) Phosphorylated IkBα (Ser32, #2859), Phosphorylated IKKα/ß (Ser176/180, #2697), and RelB (#4922) were purchased from Cell Signaling Technologies (Danavers, MA). Loading control β-Actin (A5441) was

(16) Inhibition of TANK‐binding kinase1 attenuates the astrocyte‐mediated neuroinflammatory response through YAP signaling after spinal cord injuryCNS Neuroscience & TherapeuticsAugust 1, 2023Wenbin Zhang, Mengxian Jia, Jiashu Lian, Sheng Lu, Jian Zhou, Ziwei Fan, Zhoule Zhu, Yaozhi He, Changgang Huang, Mingyu Zhu, et al.(1:1000, #4911, CST), rabbit anti‐NF‐κB2 p100/p52 (1:1000, #4882, CST), rabbit anti‐RelB (1:1000, #4922, CST), rabbit anti‐phospho‐IRF3 (1:1000, #37829, CST), mouse anti‐GAPDH (1:5000, #2118, CST), rabbit

(17) An EZH2-NF-κB regulatory axis drives expression of pro-oncogenic gene signatures in triple negative breast canceriScienceJuly 21, 2023Dardis GJ, Wang J, Simon JM, Wang GG, Baldwin AS.mAb,Cell Signaling Technology,Cat# 8242; RRID:AB_10859369 RelB Rabbit mAb,Cell Signaling Technology,Cat# 4922; RRID:AB_2179173 NFKB2 p100/p52 Rabbit polyclonal,Cell Signaling Technology,Cat# 4882; RRID:AB_10695537 DAB2IP

(18) Characterization of Target Gene Regulation by the Two Epstein-Barr Virus Oncogene LMP1 Domains Essential for B-cell TransformationbioRxivApril 13, 2023Bidisha Mitra, Rui Guo, Eric M. Burton, Laura A. Murray-Nerger, Benjamin E. Gewurzp105/50 (#3035, Rabbit mAb), RelA (#8242, Rabbit mAb), phospho-RelA (Ser536) (3033, Rabbit mAb), RelB (#4922, Rabbit mAb), cRel (#4727, Rabbit mAb), IκBα (#9247, Mouse mAb), IRF4 (#4964, Rabbit mAb), TAK1 (#4505,

(19) Aberrant accumulation of NIK promotes tumor growth by dysregulating translation and post-translational modifications in breast cancerCancer Cell InternationalApril 1, 2023Yusuke Hayashi, Jun Nakayama, Mizuki Yamamoto, Masashi Maekawa, Shinya Watanabe, Shigeki Higashiyama, Jun-ichiro Inoue, Yusuke Yamamoto, Kentaro SembaSigma-Aldrich Co., MO, USA, 1:200), NF-κB2 (#05–361, Merck, Darmstadt, Deutschland, 1:100), RelB (#4922, Cell Signaling Technology, 1:100) at 4 °C overnight. Then, cells were incubated with Hoechst 33342

(20) Tumor cells-derived conditioned medium induced pro-tumoral phenotypes in macrophages through calcium-nuclear factor κB interactionBMC cancerDecember 19, 2022Zhang Y, Zhang Z, Chen L, Zhang X.rabbit anti-p65 (8242S, Cell Signaling), rabbit anti-p-RelB (5025S, Cell Signaling), rabbit anti-RelB (4922S, Cell Signaling), rabbit anti-p-IKK (2697S, Cell Signaling), rabbit anti-IKK \documentclass[12pt]{minimal}

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RelB (C1E4) Rabbit mAb

RelB (C1E4) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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RelB (C1E4) Rabbit mAb from Cell Signaling Technology

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