FoxO3a (D19A7) Rabbit mAb 12829S from Cell Signaling Technology

Product Specs
ItemFoxO3a (D19A7) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number12829S
Quantity100 µl
ApplicationsW, W-S, IP, IHC-P, IF-IC, FC-FP
ReactivityH, M, R
TargetFoxO3a
HostRabbit
NCBI Full Gene Nameforkhead box O3
NCBI Gene AliasesAF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A
ClonalityMonoclonal
Research AreaPI3K / Akt Signaling
IsotypeIgG
CloneD19A7
Molecular Weight82 to 97

Questions and Answers

Can this antibody be used to study the role of FoxO3a in cancer cell signaling?

Yes, the FoxO3a (D19A7) Rabbit mAb has been utilized in various studies to investigate its role in cancer cell signaling. For instance, it was used in research examining the ALK-AKT-FOXO3a axis in ALK-driven neuroblastomas, highlighting its importance in regulating apoptosis and cell cycle arrest in response to treatment (Miyazaki et al., 2018).

What applications has this antibody been shown to work in?

The FoxO3a (D19A7) Rabbit mAb has been shown to work in several applications, including Western blotting, immunofluorescence microscopy, immunocytochemistry, and immunohistochemistry. It has been effectively used to analyze FoxO3a protein levels and its phosphorylation status in various experimental setups (Gómez-SanMiguel et al., 2016; Jia et al., 2019).

Is this antibody effective for detecting FoxO3a in different species?

Yes, the FoxO3a (D19A7) Rabbit mAb is reactive with multiple species, including humans, mice, and rats. This broad reactivity makes it suitable for comparative studies across different model organisms (Cell Signaling Technology).

Are there any specific findings related to FoxO3a that have been published using this antibody?

Yes, studies have demonstrated that FoxO3a plays a critical role in muscle atrophy and inflammation. For example, it was shown that FoxO3a is involved in the regulation of muscle proteolysis in response to inflammatory signals, with the antibody being used to assess its expression and activity in various experimental models (Kim et al., 2021; Shen et al., 2024).

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Website: Technical Support

(1) RIPK3 Inhibition Mitigates Denervated Muscle Atrophy via NOX4-Mediated Mitochondrial Restoration and Inflammation SuppressionJ Cachexia Sarcopenia MuscleMay 1, 2026Yuntian Shen, Chen Zhang, Zihao Zhao, Jia Yi, Xinlei Yao, Bingqian Chen, Hualin Sun(R&D Systems, #MAB4470), TRIM63 (Signalway Antibody, #38580), Fbx32 (Abcam, #ab168372), FoxO3a (CST, #12829S), PGC‐1α (Abcam, #ab191838), Nrf2 (Abcam, #ab137550), p‐DRP1(Ser616) (CST, #4494), DRP1 (CST, #8570),

(2) Puerarin-Rich Pueraria lobata Extract Attenuates H2O2- and Dexamethasone-Induced Atrophy in C2C12 Myoblasts and MyotubesPrev Nutr Food SciApril 13, 2026Young Han Kim, Jae In Jung, Soung Yong Park, Jae-Hoon Shim, Young Seung Lee, Seong Il Heo#2983), phospho-FoxO3a (Ser253; Cell Signaling Technology, #9466), FoxO3a (Cell Signaling Technology, #12829), and β-actin (Cell Signaling Technology, #4970). The membranes were then incubated with horseradish

(3) IL-27-Ucp2-FoxO3 axis mediating the polarization of alternatively activated macrophages and ameliorating inflammatory painKorean J PainApril 1, 2026Yi Ma, Shuyuan Gan, Yueying Zheng, Xianhui Kang, Shengmei ZhumAb,CST,#93668 β-Actin,ProteinTech,66009-1-Ig GAPDH,ProteinTech,60004-1-Ig FoxO3 (D19A7) Rabbit mAb,"CST, US",#12829 Mouse Wsx-1 Antibody,R&D System,MAB21091 CoraLite488-conjugated Goat Anti-Rabbit IgG (H + L)ROS Fluorometric

(4) Dual targeting of PI3Kδ and PPARα enhances antitumor activity via FoxO1 activation in follicular lymphomaCell Death & DiseaseMarch 23, 2026Wenqin Wang, Hui Zhou, Shuangxiong Tan, Dongmei Qin, Shuxuan Wang, Chunlan Xu, Xiangru Lei, Wenjuan Li, Liangjie Wang, Shuhui Fu, et al.(ab227074; Abcam), FoxO1 (#2880; CST), phospho-FoxO1 (Thr24, #9464; CST) and (Ser256, #9461; CST), FoxO3a (#12829; CST), FoxO4 (#9472; CST), Mcl-1 (#16225-1-AP; Proteintech), Bcl-2 (#12789-1-AP; Proteintech), Bim (A19702;

(5) NCOA2 promotes the return of hematopoietic stem cells to quiescence after irradiation stress by regulating FOXO3a-dependent mitophagyHemasphereMarch 7, 2026Fang Chen, Naicheng Chen, Linjie Wang, Hao Zeng, Yukai Lu, Yanying Liu, Jing Chen, Yang Xu, Mo Chen, Song Wang, et al.(#sc‐365827, Santa Cruz, Dallas, TX, USA), anti‐PINK1 (#ab23707, Abcam, Cambridge, UK), anti‐FOXO3a (#12829, Cell Signaling Technology, Danvers, MA, USA), anti‐Phospho‐FOXO3aSer253 (#9466, Cell Signaling Technology),

(6) Mitigating psychological stress-induced cardiac injury: The impact of CB2R agonists on endoplasmic reticulum stress and mitophagyBiochemistry and Biophysics ReportsMarch 1, 2026Chenke Ma, Wenbin Gai, Kan Zhang, Cheng Qinfollowing primary antibodies: PPARγ (Abcam, UK, ab178860), FOXO3 (Cell Signaling Technology, USA, #12829), STAT3 (Abclonal, China, A22434), and SIRT1 (Abclonal, China, A0230). The Western blot procedures were

(7) Insulin Receptor Expression and its Association with Hyperinsulinemia in Triple Negative Breast CancerJournal of the Endocrine SocietyFebruary 17, 2026Alexis J Engel, Krupa Samuel, Ilana R Bass, Sylvia Lin, Irini Markella Antoniou, Radhi Yagnik, Elisa Port, Sheldon M Feldman, Neil B Friedman, Susan K Boolbol, et al.anti-IGF-1R Ab (#3027, Cell Signaling, Danvers, CA, RRID:AB_2122378) 1:200 dilution, anti-FOXO3a Ab (#12829, Cell Signaling, RRID:AB_2636990) 1:3200 dilution, and anti-pErk1/2 (Thr202/Tyr204) Ab (#4370, Cell Signaling

(8) Overexpression of FoxO3a in the dentate gyrus alleviates CUS-induced anxiety- and depression-like behaviors and cognitive impairmentBehavioral and Brain FunctionsFebruary 1, 2026Shanyong Yi, Bin Yang, Xianxian Zhang, Bin Zhao, Lai Wei, Zhijun Yao, Ruiling ZhangWuhan, China). The membranes were incubated with rabbit FoxO3a monoclonal antibody (1: 2000, CST, #12829, MA, USA), mouse PSD95 monoclonal antibody (1: 1000, CST, #36233, MA, USA), rabbit SYN monoclonal antibody

(9) Dual epigenetic and nuclear export inhibition by chidamide and selinexor in high grade B-cell lymphomas via survivin and PI3K/AKT inhibitionClinical EpigeneticsJanuary 26, 2026Jiazhen Lin, Xinguo Zhuang, Shuman Jia, Hui Zhou, Dongmei Qin, Jie Zhou, Bozhang Chen, Mingxin Zhuang, Bing Xu, Jie Zhaof various proteins, a range of primary antibodies were used. Survivin (2808), FOXO1(2880), FOXO3a(12829) and CyclinA2 (4656T) antibodies were obtained from Cell Signaling Technology (Danvers, Massachusetts,

(10) Distinct signaling mechanisms and proteome phenotypes are elicited by compartment-specific genetic defects of copper homeostasisbioRxivJanuary 15, 2026Alicia R. Lane, Nadia Gonzalez, Avanti Gokhale, Stephanie A. Zlatic, Brooke M. Allen, Noah E. Scher, Anne M. Roberts, Duc M. Duong, Blaine R. Roberts, Alysia D. Vrailas-Mortimer, et al.67221-1-IG,AB_2919440 DBH,1:500,Millipore AB1536,AB_2089474 DEPTOR,1:1000,Cell Signaling 11816,AB_2750575 FOXO3,1:1000,Cell Signaling 12829,AB_2636990 GM130,1:250,BD Biosciences 610822,AB_398141 HSP90,1:1000,BD Biosciences 610418,AB_397798 Integrin

(11) Nebulized bone marrow-derived stem cell supernatant induces tolerogenic dendritic cells via upregulation of FOXO3 for EAE treatmentJournal of NeuroinflammationJanuary 14, 2026Junfeng Wu, Zhixin Qiao, Yanping Wang, Sifan Zhang, Jiayu Ji, Xiaoru Ma, Xiyu Zhang, Xin Xiu, Xiujuan Lang, Xijun Liu, et al.temperature for 90 min to reduce nonspecific binding. Primary antibodies FOXO3 (1:500, CellSignaling, 12829, USA) and CD11c (1:500, ThermoFisher, 14-0114-82, USA) were added and incubated overnight at 4℃. The

(12) Composite dietary fiber alleviates obesity-induced skeletal muscle atrophy by regulating gut microbiota-derived short-chain fatty acids in micenpj Science of FoodJanuary 9, 2026Yutong Xie, Dazhang Deng, Shan Wang, Zhixin Li, Tingyi Mo, Ya Wang, Honghui GuoTechnology Co., Ltd. (Beijing, China). Antibodies used were as follows: FoxO3a (Cell Signaling Technology, #12829), phospho-FoxO3a (Ser253) (HUABIO, ST49-01), Atrogin-1 (Proteintech, 67172-1-Ig, RRID: AB_2882468),

(13) Lactobacillus gasseri CBT LGA2 alleviates muscle protein degradation and inflammation in immobilization-induced mouseFrontiers in MicrobiologyJanuary 7, 2026Ji Hun Jang, So Jeong Lim, Hyo Su Choi, Sanghyun Lim, Nam Su Ohserum albumin (BSA). The following antibodies were used: phospho-FOXO3a (Ser253, #9465) and FOXO3a (#12829) (Cell Signaling Technology, Danvers, MA, United States); Atrogin-1 (sc-166806) and MuRF1 (sc-398608)

(14) TLR9 decreases FOXO3 expression to prevent excessive inflammation in macrophage activation syndromeiScienceDecember 19, 2025Mengyan Wang, Yuning Ma, Jianfen Meng, Chengde Yang, Dehao Zhu, Xia Chen, Longfang Chen, Yu Xiao, Da Yi, Hui Shi, et al.agarose gel electrophoresis. 2% sample was saved as input. Remaining samples was incubated with antibodies for FoxO3 (12829, D19A7 clone, CST) for IP and normal rabbit IgG (A7016, Beyotime) as negative control, at 4°C for overnight.

(15) Lung adenocarcinoma surfaceome remodeling with EGFR inhibitors uncovers placental alkaline phosphatase as a target for combination therapyCell Rep MedDecember 16, 2025Yihui Chen, Rongzhang Dou, Monica J. Hong, Hanwen Xu, Jody Vykoukal, Ricardo A. León-Letelier, Yining Cai, Soyoung Park, Ehsan Irajizad, Fu Chung Hsiao, et al.,Cell Signaling Technology,Cat# 5174; RRID:AB_10622025 FoxO3a (D19A7) Antibody,Cell Signaling Technology,Cat# 12829; RRID:AB_2636990 Phospho-FoxO3a (Ser294) Antibody,Cell Signaling Technology,Cat# 5538; RRID:AB_10696878 Phospho-FoxO3a

(16) Prognostic value of BTG1 for predicting decitabine sensitivity in de novo acute myeloid leukemiaiScienceDecember 3, 2025Shiyuan Zhang, Mengyuan Li, Bin Xu, Xiaojian Zhu, Xia Mao, Hao Zhou, Xiwen Tong, Shuai Su, Yi Zhu, Donghua Zhangβ-actin,Immunoway,Cat# YM8343RRID: AB_3675707 Rabbit monoclonal anti-human FOXO3a,Cell Signaling Technology,Cat# 12829;RRID:AB_2636990 Rabbit monoclonal anti-human DMNT1,Immunoway,Cat# YM8362 Mouse monoclonal anti-human

(17) In vitro system completely restores oogenesis in congenitally infertile miceHuman ReproductionDecember 1, 2025K Yoshida, S Kimura, M Taguchi, H Morimoto, M Kanatsu-Shinohara, T Shinohara, Y Obata(1:200, Cat No. 4857; Cell Signaling Technology, Danvers, MA, USA), and rabbit anti-FOXO3 (1:200, Cat No. 12829; Cell Signaling Technology) primary antibodies were used. The sections were washed and subsequently

(18) Somatic Kitl promotes mTOR to facilitate prophase I of meiosis in female embryonic gonadsCell Death & DiseaseNovember 17, 2025Chang Liu, Ziyi Jin, Jiyu Chen, Jie Li, Guofeng Feng, Guoxing Yin, Yongqin Yu, Xiaoying Ye, Haowei Sun, Hua Zhang, et al.1:1000; p-AKT, 2965S, CST, 1:1000; AKT, 4691S, CST, 1:1000; p-Stat3, ab76315, Abcam, 1:1000; Foxo3a, 12829, CST, 1:1000; p-ERK, 9101S, CST, 1:1000; and ERK, SC93, Santa Cruz, 1:2000), and β-actin (P30002, Abmart,

(19) Okanin Attenuates Mitochondrial Dysfunction and Apoptosis in UVA-Induced HaCaT Cells by Mitophagy Through SIRT3 PathwayAntioxidants (Basel)August 23, 2025Fang Lu, Jiangming Zhong, Qi Zhou, Yiwei Yu, Mengdi Liang, Ying Yuan, Aowei Xie, Jin Cheng, Peng Shu, Jiejie Hao(#11998), LC3A/B (#12741), SQSTM1/p62 (#39749), PINK1 (#6946), Parkin (#32833), SIRT3 (#2627), FOXO3a (#12829), Phospho-Histone H2A.X (#9718), Bax (#5023), Bcl-2 (#3498), Cytochrome c (#11940) and caspase-3 (#14220)

(20) Enhanced SLC2A4 expression mitigates insulin resistance in gestational diabetes mellitus via the FoxO signaling pathway in vitroExperimental and Therapeutic MedicineAugust 22, 2025Yanqi Jin, Xiaoyan Cheng, Jinting Wu, Yi Zhu, Hui Xu, Chunyu CaoCell Signaling Technology, Inc.), p-FoxO3a (cat. no. 13129S; Cell Signaling Technology, Inc.), FoxO3a (cat. no. 12829S; Cell Signaling Technology, Inc.) and GAPDH (cat. no. 97166; Cell Signaling Technology, Inc.) (all 1:1,000

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FoxO3a (D19A7) Rabbit mAb

FoxO3a (D19A7) Rabbit mAb from Cell Signaling Technology

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FoxO3a (D19A7) Rabbit mAb from Cell Signaling Technology

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