Acetyl-Histone H2B (Lys5) (D5H1S) XP ® Rabbit mAb 12799S from Cell Signaling Technology

Product Specs
ItemAcetyl-Histone H2B (Lys5) (D5H1S) XP ® Rabbit mAb
CompanyCell Signaling Technology
Price $431.00 Inquire
Catalog Number12799S
Quantity100 µl
ApplicationsW, IP, IHC-P, IF-IC, ChIP
ReactivityH, M, R, Mk
TargetH2B (Lys5) acetylate
HostRabbit
NCBI Full Gene NameH2B clustered histone 3
NCBI Gene AliasesH2B.1, H2B/f, H2BFF, HIST1H2BB
ClonalityMonoclonal
ModificationsH2B (Lys5) acetylate
Research AreaChromatin Regulation / Nuclear Function
CloneD5H1S
Molecular Weight14

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Cell Signaling Technology

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Danvers, Massachusetts 01923

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Phone: 877-616-CELL
Phone: 978-867-2388
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Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) NAD+ sensing by PARP7 regulates the C/EBPβ-dependent transcription program during adipogenesisCell ReportsFebruary 24, 2026MiKayla S. Stokes, Yoon Jung Kim, Yonghyeon Kim, Sneh Koul, Shu-Ping Chiu, Chenqian Liu, Morgan Dasovich, Josue Zuniga, Tulip Nandu, Dan Huang, et al.Histone H3K27ac (Active Motif, 39134; RRID:AB_2722569), Histone H2BK5ac (Cell Signaling Technology, 12799; RRID:AB_2636805), Histone H3K27me3 (Cell Signaling Technology, 9733; RRID:AB_2616029), FLAG (Sigma-Aldrich,

(2) DNA damage induced by HIV-1 Vpr triggers epigenetic remodeling and transcriptional programs to enhance virus transcription and latency reactivationPLoS BiolFebruary 2, 2026Nicholas Saladino, Emily Leavitt, Hoi Tong Wong, Jae-Hoon Ji, Diako Ebrahimi, Daniel J. SalamangoCell Signaling 75336), total H2B (1:1,000, Cell Signaling 12364), acetyl-histone H2BK5 (1:1,000, Cell Signaling 12799), acetyl-histone H2BK12 (1:1,000, Cell Signaling 5410), acetyl-histone H2BK15 (1:1,000, Cell Signaling

(3) Short-Chain Fatty Acids Elicit Differential Expression of Growth Factors and Pro-Inflammatory Cytokines in Immortalized Rat Enteric Glial CellsNutrientsJanuary 29, 2026Michelle M. Beltran, Danielle M. Defriesbefore being probed with primary antibodies (histone H2B, catalog #12364; acetyl-histone H2B, catalog #12799; histone H3, catalog #4499; acetyl-histone H3, catalog #9649, Cell Signaling Technology, Danvers, MA,

(4) Overexpression of ATase1 and ATase2 disrupts the secretome and causes a progeria phenotypeLife science allianceDecember 1, 2025Cheng TL, Wu F, Haque ME, Thiel AR, Wang D, Helgager JJ, Li L, Puglielli L.1:1,000; NOVUS), Acetyl-Histone H2A Lys5 (#2576, 1:1,000; Cell Signaling), Acetyl-Histone H2B Lys5 (#12799, 1:1,000; Cell Signaling), Acetyl-Histone H3 Lys9 (#9649, 1:1,000; Cell Signaling), Lys14 (#7627, 1:1,000;

(5) Targeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancerNat GenetOctober 3, 2025Jie Luo, Zhixiang Chen, Yuanyuan Qiao, Jean Ching-Yi Tien, Eleanor Young, Rahul Mannan, Somnath Mahapatra, Rupam Bhattacharyya, Lanbo Xiao, Tongchen He, et al.Invitrogen, PA5-27369); AR (1:1,000; Abcam, ab133273); H2BK5ac (1:1,000; Cell Signaling Technology, 12799S); H2BK20ac (1:1,000; Cell Signaling Technology, 34156S); H2BK12ac (1:1,000; Abcam, ab40883); H2BK16ac

(6) IFI16 Mediates Deacetylation of KSHV Chromatin via Interaction with NuRD and Sin3A Co-Repressor ComplexesVirusesJune 28, 2025Anandita Ghosh, Bala Chandran, Arunava Roy2576); Histone H2B anti-rabbit (Cell Signaling 12364); Acetyl-Histone H2B anti-rabbit (Cell Signaling, 12799); Histone H3 anti-rabbit (Cell Signaling, 4499); Acetyl-Histone H3 anti-rabbit (Cell Signaling, 8173);

(7) New potent N-hydroxycinnamamide-based histone deacetylase inhibitors suppress proliferation and trigger apoptosis in THP-1 leukaemia cellsArch Pharm (Weinheim)April 1, 2025Magdalena Onuscakova, Tereza Kauerova, Eva Fialova, Hana Pizova, Vladimir Garaj, Miroslav Kemka, Vladimir Frecer, Peter Kollar, Pavel Bobal(sc‐16670‐R), cleaved PARP (D64E10, 5625), acetyl‐histone H2A [Lys5] (2576), acetyl‐histone H2B [Lys5] (D5H1S, 12799), acetyl‐histone H3 [Lys9] (C5B11, 9649) and acetyl‐histone H4 [Lys8] (2594) were purchased Cell Signalling

(8) KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transitionCell ReportsFebruary 25, 2025Deniz Gökbuget, Liana Goehring, Ryan M. Boileau, Kayla Lenshoek, Tony T. Huang, Robert Blelloch14111; RRID:AB_2798395 H3K36me2,Cell Signaling,Cat# 2901; RRID:AB_1030983 H2BK5ac,Cell Signaling,Cat# 12799; RRID:AB_2636805 H3K9ac,Cell Signaling,Cat# 9649; RRID:AB_823528 H3K9me3,Active Motif,Cat# 39162;

(9) HIV-1 Vpr drives epigenetic remodeling to enhance virus transcription and latency reactivationbioRxivJanuary 31, 2025Nicholas Saladino, Emily Leavitt, Hoi Tong Wong, Jae-Hoon Ji, Diako Ebrahimi, Daniel J SalamangoCell Signaling 75336), total H2B (1:1000, Cell Signaling 12364), acetyl-histone H2BK5 (1:1000, Cell Signaling 12799), acetyl-histone H2BK12 (1:1000, Cell Signaling 5410), acetyl-histone H2BK15 (1:1000, Cell Signaling

(10) Sensitive Detection of Histones and γ-H2AX by Immunoblotting: Problems and SolutionsChemical research in toxicologySeptember 16, 2024Krawic C, Luczak MW, Zhitkovich A.(Cell Signaling, 12364 and Millipore, 07–371), H2Bub1 (Cell Signaling, 5546), H2BK5ac (Cell Signaling, 12799), H3 (Cell Signaling, 9715), H3.3 (Novus, NBP2–24697), H3K9ac (Cell Signaling, 9649), H3K4me3 (Millipore,

(11) p300/CBP degradation is required to disable the active AR enhanceosome in prostate cancerbioRxivAugust 26, 2024Jie Luo, Zhixiang Chen, Yuanyuan Qiao, Jean Ching-Yi Ching-Yi Tien, Eleanor Young, Rahul Mannan, Somnath Mahapatra, Tongchen He, Sanjana Eyunni, Yuping Zhang, et al.MA1–16608); CBP (Invitrogen: PA5–27369); AR (Abcam: ab133273); H2BK5ac (Cell Signaling Technology: 12799S); H2BK20ac (Cell Signaling Technology: 34156S); H2BK12ac (Abcam: ab40883); H2BK16ac (Abcam: ab177427);

(12) Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1α/HMOX1 axisMolecular medicine (Cambridge, Mass.)July 6, 2023Shi J, Wang QH, Wei X, Huo B, Ye JN, Yi X, Feng X, Fang ZM, Jiang DS, Ma MJ.HIF-1α (20960-1-AP, Proteintech Group), H3K18ac (ab40888, Abcam), H3K27ac (GTX128944, GeneTex), H2BK5ac (12799, Cell Signaling Technology), AIFM2/FSP1 (HPA042309, Atlas Antibodies; 20886-1-AP, Proteintech Group),

(13) Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancerClinical epigeneticsNovember 12, 2022Shozu K, Kaneko S, Shinkai N, Dozen A, Kosuge H, Nakakido M, Machino H, Takasawa K, Asada K, Komatsu M, et al.Cell Signaling Technology, Denver, CO, USA), H4K16ac (#13534; 1:50, Cell Signaling Technology, Denver, CO, USA), H2BK5ac (#12799; 1:50, Cell Signaling Technology, Denver, CO, USA), H2BK12ac (#9072; 1:50, Cell Signaling Technology,

(14) The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccinationCellJuly 22, 2021Wimmers F, Donato M, Kuo A, Ashuach T, Gupta S, Li C, Dvorak M, Foecke MH, Chang SE, Hagan T, et al.formulation*) Rabbit monoclonal anti-acetyl-Histone H2B(Lys5) (clone D5H1S),Cell Signaling Technology,Cat#: 12799 (custom formulation*) Mouse monoclonal anti-phospho-HistoneH3 (Ser10) (clone MABI 0312),Active Motif,Cat#:

(15) Pharmacological Inhibition of CBP/p300 Blocks Estrogen Receptor Alpha (ERα) Function through Suppressing Enhancer H3K27 Acetylation in Luminal Breast CancerCancersJune 4, 2021Waddell A, Mahmud I, Ding H, Huo Z, Liao D.Cell Signaling Technology), H3K9ac (9649, Cell Signaling Technology), H3 (3638, Cell Signaling Technology), H2BK5ac (12799, Cell Signaling Technology), H2BK12ac (1755-1, Epitomics), H2B (12364BC, Cell Signaling Technology),

(16) Histone Deacetylases Regulation by δ-Opioids in Human Optic Nerve Head AstrocytesInvestigative ophthalmology & visual scienceSeptember 1, 2020Zaidi SAH, Thakore N, Singh S, Guzman W, Mehrotra S, Gangaraju V, Husain S.(AcH4K8),Cell Signaling Technology,2594 Anti-Acetyl Histone 2B Lys 5 (AcH2BK5),Cell Signaling Technology,12799 Anti-Histone Deacetylase (HDAC)-1,Millipore,06-720 Anti-Histone Deacetylase (HDAC)-2,Millipore,05-814 Anti-Histone

(17) Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with AgingCellMay 31, 2018Cheung P, Vallania F, Warsinske HC, Donato M, Schaffert S, Chang SE, Dvorak M, Dekker CL, Davis MM, Utz PJ, et al.formulation*) Rabbit monoclonal anti-acetyl-Histone H2B (Lys5) (clone D5H1S),Cell Signaling Technology,12799 (custom formulation*) Mouse monoclonal anti-phospho-Histone H3 (Ser10) (clone MABI 0312),Active Motif,39636 Mouse

(18) Glycolytic metabolism influences global chromatin structureOncotargetFebruary 28, 2015Xue-Song Liu, John B. Little, Zhi-Min Yuanantibody (Cell Signaling, #2935); H2AK5 antibody (Cell Signaling, #2576); H2BK5 antibody (Cell Signaling, #12799); H3K9Ac antibody (Cell Signaling, #9649); H3K14Ac antibody (Cell Signaling, #7627); H3K27Ac antibody

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Acetyl-Histone H2B (Lys5) (D5H1S) XP ® Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

Citations (18)

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Acetyl-Histone H2B (Lys5) (D5H1S) XP ® Rabbit mAb from Cell Signaling Technology

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